A computational analysis of the effect of sevoflurane in a human ventricular cell model of long QT syndrome: Importance of repolarization reserve in the QT-prolonging effect of sevoflurane.
Action Potentials
/ drug effects
Case-Control Studies
Computer Simulation
Delayed Rectifier Potassium Channels
/ genetics
Heart Rate
/ drug effects
Heart Ventricles
/ drug effects
Humans
Long QT Syndrome
/ chemically induced
Models, Cardiovascular
Myocytes, Cardiac
/ drug effects
Propofol
/ toxicity
Risk Assessment
Risk Factors
Romano-Ward Syndrome
/ chemically induced
Sevoflurane
/ toxicity
Time Factors
I(Kr)
I(Ks)
Long QT syndrome
QT interval
Repolarization reserve
Sevoflurane
Journal
European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354
Informations de publication
Date de publication:
15 Sep 2020
15 Sep 2020
Historique:
received:
08
05
2020
revised:
26
06
2020
accepted:
13
07
2020
pubmed:
28
7
2020
medline:
19
5
2021
entrez:
26
7
2020
Statut:
ppublish
Résumé
The slowly and rapidly activating delayed rectifier K
Identifiants
pubmed: 32710951
pii: S0014-2999(20)30470-2
doi: 10.1016/j.ejphar.2020.173378
pii:
doi:
Substances chimiques
Delayed Rectifier Potassium Channels
0
Sevoflurane
38LVP0K73A
Propofol
YI7VU623SF
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
173378Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.