Degradable double hydrophilic block copolymers and tripartite polyionic complex micelles thereof for small interfering ribonucleic acids (siRNA) delivery.
Cancer cells
Degradable double hydrophilic block copolymers
Functional poly(ε-caprolactone)
Gene therapy
Mesenchymal stem cells
Tripartite polyion complex micelles (PIC)
pH sensitive micelles
siRNA
Journal
Journal of colloid and interface science
ISSN: 1095-7103
Titre abrégé: J Colloid Interface Sci
Pays: United States
ID NLM: 0043125
Informations de publication
Date de publication:
15 Nov 2020
15 Nov 2020
Historique:
received:
26
04
2020
revised:
22
06
2020
accepted:
11
07
2020
pubmed:
28
7
2020
medline:
22
6
2021
entrez:
26
7
2020
Statut:
ppublish
Résumé
Polymer vectors for gene therapy have been largely investigated as an alternative to viral vectors. In particular, double hydrophilic block copolymers (DHBCs) have shown potential in this domain, but to date studies mainly focus on non-degradable copolymers, which may be a restriction for further development. To overcome this limitation, we synthesized a DHBC (PEG
Identifiants
pubmed: 32711196
pii: S0021-9797(20)30932-2
doi: 10.1016/j.jcis.2020.07.057
pii:
doi:
Substances chimiques
Micelles
0
Polymers
0
RNA, Small Interfering
0
Polyethylene Glycols
3WJQ0SDW1A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
449-459Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.