Reverse genetic systems: Rational design of coronavirus live attenuated vaccines with immune sequelae.
Betacoronavirus
/ immunology
COVID-19
Coronavirus Infections
/ immunology
Genome, Viral
/ genetics
Humans
Pandemics
/ prevention & control
Pneumonia, Viral
/ immunology
RNA, Viral
/ genetics
Reverse Genetics
/ methods
SARS-CoV-2
Vaccines, Synthetic
/ immunology
Viral Proteins
/ genetics
Viral Vaccines
/ immunology
Coronavirus
Live attenuated vaccine
Reverse genetics
Journal
Advances in virus research
ISSN: 1557-8399
Titre abrégé: Adv Virus Res
Pays: United States
ID NLM: 0370441
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
27
7
2020
pubmed:
28
7
2020
medline:
4
8
2020
Statut:
ppublish
Résumé
Since the end of 2019, the global COVID-19 outbreak has once again made coronaviruses a hot topic. Vaccines are hoped to be an effective way to stop the spread of the virus. However, there are no clinically approved vaccines available for coronavirus infections. Reverse genetics technology can realize the operation of RNA virus genomes at the DNA level and provide new ideas and strategies for the development of new vaccines. In this review, we systematically describe the role of reverse genetics technology in studying the effects of coronavirus proteins on viral virulence and innate immunity, cell and tissue tropism and antiviral drug screening. An efficient reverse genetics platform is useful for obtaining the ideal attenuated strain to prepare an attenuated live vaccine.
Identifiants
pubmed: 32711735
pii: S0065-3527(20)30021-X
doi: 10.1016/bs.aivir.2020.06.003
pmc: PMC7326460
pii:
doi:
Substances chimiques
RNA, Viral
0
Vaccines, Synthetic
0
Viral Proteins
0
Viral Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
383-416Informations de copyright
© 2020 Elsevier Inc. All rights reserved.
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