Elevated Interleukin-6 Levels Predict Clinical Worsening in Pediatric Pulmonary Arterial Hypertension.
Journal
The Journal of pediatrics
ISSN: 1097-6833
Titre abrégé: J Pediatr
Pays: United States
ID NLM: 0375410
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
20
12
2019
revised:
20
02
2020
accepted:
14
04
2020
entrez:
27
7
2020
pubmed:
28
7
2020
medline:
2
12
2020
Statut:
ppublish
Résumé
To assess whether circulating interleukin-6 (IL-6) is associated with measures of disease severity and clinical worsening in pediatric pulmonary arterial hypertension (PAH). IL-6 was measured by enzyme-linked immunosorbent assay in serum samples from a cross-sectional cohort from the National Heart, Lung, and Blood Institute Pulmonary Arterial Hypertension Biobank (n = 175) and a longitudinal cohort from Children's Hospital Colorado (CHC) (n = 61). Associations between IL-6, disease severity, and outcomes were studied with regression and Kaplan-Meier analysis. In analyses adjusted for age and sex, each log-unit greater IL-6 was significantly associated in the Pulmonary Arterial Hypertension Biobank cohort with greater pulmonary vascular resistance indices, lower odds of having idiopathic PAH or treatment with prostacyclin, and greater odds of having PAH associated with a repaired congenital shunt. In the CHC cohort, each log-unit greater IL-6 was significantly associated with greater mean pulmonary arterial pressure over time. Kaplan-Meier analysis in the CHC cohort revealed that IL-6 was significantly associated with clinical worsening (a composite score of mortality, transplant, or palliative surgery) (P = .037). IL-6 was significantly associated with worse hemodynamics at baseline and over time and may be associated with clinical worsening. IL-6 may provide a less-invasive method for disease monitoring and prognosis in pediatric PAH as well as a potential therapeutic target.
Identifiants
pubmed: 32711743
pii: S0022-3476(20)30496-0
doi: 10.1016/j.jpeds.2020.04.041
pmc: PMC7388069
mid: NIHMS1588917
pii:
doi:
Substances chimiques
Biomarkers
0
Interleukin-6
0
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
164-169.e1Subventions
Organisme : NHLBI NIH HHS
ID : R24 HL105333
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL153781
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD000850
Pays : United States
Organisme : NHLBI NIH HHS
ID : R24 HL123767
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL135114
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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