Photobiomodulation therapy improves the growth factor and cytokine secretory profile in human type 2 diabetic fibroblasts.
Case-Control Studies
Cell Movement
/ radiation effects
Cell Proliferation
/ radiation effects
Cell Survival
/ radiation effects
Cells, Cultured
Cytokines
/ metabolism
Diabetes Mellitus, Type 2
/ metabolism
Fibroblasts
/ cytology
Humans
Intercellular Signaling Peptides and Proteins
/ metabolism
Lasers, Gas
Male
Middle Aged
Diabetic wound
Human fibroblast
Photobiomodulation therapy
Secretory profile
Type 2 diabetes
Journal
Journal of photochemistry and photobiology. B, Biology
ISSN: 1873-2682
Titre abrégé: J Photochem Photobiol B
Pays: Switzerland
ID NLM: 8804966
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
08
01
2020
revised:
08
07
2020
accepted:
13
07
2020
pubmed:
28
7
2020
medline:
7
4
2021
entrez:
27
7
2020
Statut:
ppublish
Résumé
Impaired wound healing is a common complication of diabetes mellitus (DM) and the underlying mechanism of this impairment is still unclear. Fibroblast, as the main reconstructing cell, secretes some critical growth factors and cytokine contributing to wound healing. It is well known that DM alters the behavior of these cells and photobiomodulation therapy (PBMT) compensates some impairments in diabetic fibroblasts. Therefore, the aim of the present study was to demonstrate the impact of diabetes and the role of PBMT through low level laser irradiation on secretory profile of human diabetic fibroblasts. Primary human dermal fibroblasts from normal (HDFs) and diabetic (DHDFs) donors were harvested. For PBMT, the DHDFs were irradiated with a Helium-Neon laser at 632.8 nm wavelength and energy density of 0.5 J/cm
Identifiants
pubmed: 32712344
pii: S1011-1344(20)30412-7
doi: 10.1016/j.jphotobiol.2020.111962
pii:
doi:
Substances chimiques
Cytokines
0
Intercellular Signaling Peptides and Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111962Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.