Sperm interactions with the female reproductive tract: A key for successful fertilization in mammals.
Exosome
Extracellular vesicle
Interaction
Oviduct
Progesterone
Protein
Spermatozoa
Utero-tubal junction
Uterus
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
01 10 2020
01 10 2020
Historique:
received:
30
03
2020
revised:
22
06
2020
accepted:
20
07
2020
pubmed:
28
7
2020
medline:
16
6
2021
entrez:
27
7
2020
Statut:
ppublish
Résumé
Sperm migration through the female genital tract is not a quiet journey. Uterine contractions quickly operate a drastic selection, leading to a very restrictive number of sperm reaching the top of uterine horns and finally, provided the presence of key molecules on sperm, the oviduct, where fertilization takes place. During hours and sometimes days before fertilization, subpopulations of spermatozoa interact with dynamic and region-specific maternal components, including soluble proteins, extracellular vesicles and epithelial cells lining the lumen of the female tract. Interactions with uterine and oviductal cells play important roles for sperm survival as they modulate the maternal immune response and allow a transient storage before ovulation. The body of work reported here highlights the importance of sperm interactions with proteins originated from both the uterine and oviductal fluids, as well as hormonal signals around the time of ovulation for sperm acquisition of fertilizing competence.
Identifiants
pubmed: 32712384
pii: S0303-7207(20)30256-2
doi: 10.1016/j.mce.2020.110956
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
110956Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.