Polyostotic Fibrous Dysplasia Mimicking Bone Involvement in Hodgkin Lymphoma: A Pediatric Case and Literature Review.
Adolescent
Antineoplastic Combined Chemotherapy Protocols
/ therapeutic use
Bleomycin
/ administration & dosage
Bone and Bones
/ diagnostic imaging
Dacarbazine
/ administration & dosage
Diagnosis, Differential
Doxorubicin
/ administration & dosage
Female
Fibrous Dysplasia, Polyostotic
/ complications
Hodgkin Disease
/ complications
Humans
Magnetic Resonance Imaging
Neoplasm Staging
Positron Emission Tomography Computed Tomography
Stem Cell Transplantation
Transplantation, Autologous
Vinblastine
/ administration & dosage
Bone involvement
Fibrous dysplasia
Hodgkin lymphoma
Journal
Acta haematologica
ISSN: 1421-9662
Titre abrégé: Acta Haematol
Pays: Switzerland
ID NLM: 0141053
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
12
2019
accepted:
28
04
2020
pubmed:
28
7
2020
medline:
7
4
2021
entrez:
27
7
2020
Statut:
ppublish
Résumé
Bone involvement in Hodgkin lymphoma (HL) is rare. The differential diagnosis between HL bone localization and other malignant or benign skeletal diseases is challenging. We report the case of a girl affected by classic HL, initially staged IVA because of supradiaphragmatic lymph nodes and skeletal involvement. After 6 ABVD (adriamycin, bleomycin, vinblastine, dacarbazine) cycles, positron emission tomography (PET) showed a complete metabolic response of the nodal localizations and a persistent, high metabolic activity of bone lesions. Salvage treatment followed by autologous stem cell transplant was carried out. After the transplant, the bone lesions maintained a high metabolic activity at PET. A targeted bone biopsy led to the diagnosis of a fibrous dysplasia excluding the presence of HL. To our knowledge, the concomitant presence of HL and fibrous dysplasia has not been previously reported. An in-depth evaluation of disease response to frontline treatment with a biopsy of the PET-hypercaptant bone lesions could have avoided overtreatment in this patient.
Identifiants
pubmed: 32712604
pii: 000508261
doi: 10.1159/000508261
doi:
Substances chimiques
Bleomycin
11056-06-7
Vinblastine
5V9KLZ54CY
Dacarbazine
7GR28W0FJI
Doxorubicin
80168379AG
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
212-217Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 S. Karger AG, Basel.