Comparative study of the effects of ziram and disulfiram on human monocyte-derived macrophage functions and polarization: involvement of zinc.
Antioxidants
/ pharmacology
Apoptosis
/ drug effects
Cell Polarity
/ drug effects
Chemokine CCL2
/ genetics
Disulfiram
/ pharmacology
Fungicides, Industrial
/ adverse effects
Humans
Interleukin-1beta
/ genetics
Interleukin-6
/ genetics
Macrophages
/ drug effects
Oxidative Stress
/ drug effects
Tumor Necrosis Factor-alpha
/ genetics
Zinc
/ pharmacology
Ziram
/ pharmacology
Cytokines
Macrophages
Oxidative burst
Pesticides
Phagocytosis
Polarization
Journal
Cell biology and toxicology
ISSN: 1573-6822
Titre abrégé: Cell Biol Toxicol
Pays: Switzerland
ID NLM: 8506639
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
02
03
2020
accepted:
03
06
2020
pubmed:
28
7
2020
medline:
24
12
2021
entrez:
27
7
2020
Statut:
ppublish
Résumé
Ziram, a zinc dithiocarbamate is widely used worldwide as a fungicide in agriculture. In order to investigate ziram-induced changes in macrophage functions and polarization, human monocytes-derived macrophages in culture were treated with ziram at 0.01-10 μmol.L
Identifiants
pubmed: 32712770
doi: 10.1007/s10565-020-09540-6
pii: 10.1007/s10565-020-09540-6
doi:
Substances chimiques
Antioxidants
0
CCL2 protein, human
0
Chemokine CCL2
0
Fungicides, Industrial
0
IL1B protein, human
0
Interleukin-1beta
0
Interleukin-6
0
Tumor Necrosis Factor-alpha
0
Ziram
73D8UA974J
Zinc
J41CSQ7QDS
Disulfiram
TR3MLJ1UAI
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
379-400Références
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