TGFβ1 induces bone formation from BMP9-activated Bone Mesenchymal Stem Cells, with possible involvement of non-canonical pathways.

Animals Calcification, Physiologic / genetics Cell Differentiation / genetics Cell Line Gene Expression Regulation, Developmental / genetics Growth Differentiation Factor 2 / genetics HSP47 Heat-Shock Proteins / genetics Humans Mesenchymal Stem Cells / cytology Mice Osteogenesis / genetics Phosphorylation / genetics Signal Transduction / genetics Transforming Growth Factor beta1 / genetics
BMP9 Bone mesenchymal stem cell HSP47 Osteogenesis TGFβ1

Journal

International journal of medical sciences
ISSN: 1449-1907
Titre abrégé: Int J Med Sci
Pays: Australia
ID NLM: 101213954

Informations de publication

Date de publication:
2020
Historique:
received: 08 03 2020
accepted: 12 06 2020
entrez: 28 7 2020
pubmed: 28 7 2020
medline: 2 6 2021
Statut: epublish

Résumé

Reconstruction of bone defects is one of the most substantial and difficult clinical challenges in orthopedics. Transforming growth factor beta 1 (TGFβ1) might play an important role in stimulating osteogenic differentiation of bone morphogenetic protein 9 (BMP9)-induced C3H10T1/2 mesenchymal stem cells. In our current study, we examined the potential synergy between TGFβ1 and BMP9 in promoting the osteogenesis of C3H10T1/2 cells, and whether such effects could contribute to bone formation

Identifiants

DOI: 10.7150/ijms.45786 PMID: 32714072 PMC: PMC7378670
pubmed: 32714072
doi: 10.7150/ijms.45786
pii: ijmsv17p1692
pmc: PMC7378670
doi:

Substances chimiques

Gdf2 protein, mouse 0
Growth Differentiation Factor 2 0
HSP47 Heat-Shock Proteins 0
Serpinh1 protein, mouse 0
Tgfb1 protein, mouse 0
Transforming Growth Factor beta1 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1692-1703

Informations de copyright

© The author(s).

Déclaration de conflit d'intérêts

Competing Interests: The authors have declared that no competing interest exists.

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Auteurs

Huan Yao (H)

The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Yulong Zou (Y)

Department of Orthopaedic Surgery, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Ke Yang (K)

The Children's Hospital, Chongqing Medical University, Chongqing, China.

Liangjun Yin (L)

Department of Orthopaedic Surgery, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Yang Liu (Y)

Department of Orthopaedic Surgery, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Ruidong Li (R)

Department of Orthopaedic Surgery, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › TGFβ1 induces bone formation from...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Calcification physiologique › TGFβ1 induces bone formation from...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › TGFβ1 induces bone formation from...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › TGFβ1 induces bone formation from...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › TGFβ1 induces bone formation from...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteurs de croissance et de différenciation › Facteur-2 de croissance et de différenciation › TGFβ1 induces bone formation from...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de choc thermique HSP47 › TGFβ1 induces bone formation from...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › TGFβ1 induces bone formation from...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › TGFβ1 induces bone formation from...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › TGFβ1 induces bone formation from...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Ostéogenèse › TGFβ1 induces bone formation from...
questionsmedicales.fr › Métabolisme › Phosphorylation › TGFβ1 induces bone formation from...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › TGFβ1 induces bone formation from...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Facteur de croissance transformant bêta-1 › TGFβ1 induces bone formation from...