Increased Dynamic Amplitude of Low Frequency Fluctuation in Primary Insomnia.
dynamic amplitude of low frequency fluctuation
functional magnetic resonance imaging
intrinsic brain activity
primary insomnia
temporal variability
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2020
2020
Historique:
received:
17
03
2020
accepted:
25
05
2020
entrez:
28
7
2020
pubmed:
28
7
2020
medline:
28
7
2020
Statut:
epublish
Résumé
The physiological mechanism underlying primary insomnia (PI) is poorly understood. Resting-state functional magnetic resonance imaging (fMRI) has emerged as a powerful tool to explore PI. However, previous studies ignore the dynamics of the brain activity. In the current study, we aimed to explore altered dynamic intrinsic brain activity in PI. Fifty-nine patients with PI and 47 matched healthy controls (HCs) were recruited and underwent resting-state fMRI. The variance of dynamic amplitude of low frequency fluctuation (dALFF) maps across time was calculated to measure the temporal variability of intrinsic brain activity and then compared between patients with PI and HCs. As a result, patients with PI presented increased variance of dALFF in the bilateral hippocampus extending to the parahippocampus, the right putamen and the right anterior insula cortex. In addition, the variance of dALFF in the right putamen was positively correlated with Self-rating Anxiety Scale (SAS) score in PI. Our results revealed increased instability of intrinsic activity in PI.
Identifiants
pubmed: 32714271
doi: 10.3389/fneur.2020.00609
pmc: PMC7344192
doi:
Types de publication
Journal Article
Langues
eng
Pagination
609Informations de copyright
Copyright © 2020 Meng, Zheng, Liu, Yin, Hua, Fu, Wu and Jiang.
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