Adrenergic Signaling in Circadian Control of Immunity.
adrenergic
circadian rhythms
immunity
noradrenaline
sympathetic nervous system
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
04
2020
accepted:
18
05
2020
entrez:
28
7
2020
pubmed:
28
7
2020
medline:
7
4
2021
Statut:
epublish
Résumé
Circadian rhythms govern a multitude of physiologic processes, both on a cell-intrinsic level and systemically, through the coordinated function of multi-organ biosystems. One such system-the adrenergic system-relies on the catecholamine neurotransmitters, adrenaline and noradrenaline, to carry out a range of biological functions. Production of these catecholamines is under dual regulation by both neural components of the sympathetic nervous system and hormonal mechanisms involving the hypothalamus-pituitary-adrenal axis. Importantly, both neural and hormonal arms receive input from the body's central clock, giving rise to the observed rhythmic variations in catecholamine levels in blood and peripheral tissues. Oscillations in catecholamine signals have the potential to influence various cellular targets expressing adrenergic receptors, including cells of the immune system. This review will focus on ways in which the body's central master clock regulates the adrenergic system to generate circadian rhythms in adrenaline and noradrenaline, and will summarize the existing literature linking circadian control of the adrenergic system to immunologic outcomes. A better understanding of the complex, multi-system pathways involved in the control of adrenergic signals may provide immunologists with new insight into mechanisms of immune regulation and precipitate the discovery of new therapeutics.
Identifiants
pubmed: 32714319
doi: 10.3389/fimmu.2020.01235
pmc: PMC7344327
doi:
Substances chimiques
Norepinephrine
X4W3ENH1CV
Epinephrine
YKH834O4BH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1235Informations de copyright
Copyright © 2020 Leach and Suzuki.
Références
Eur J Clin Invest. 1978 Apr;8(2):57-8
pubmed: 417934
J Pharm Sci. 1966 Apr;55(4):359-67
pubmed: 5335498
Neuroendocrinology. 2008;88(4):246-55
pubmed: 18562786
Proc Natl Acad Sci U S A. 1987 Jan;84(1):46-50
pubmed: 3025863
J Immunol. 2010 Jul 1;185(1):335-44
pubmed: 20505140
J Neuroinflammation. 2004 Jun 30;1(1):9
pubmed: 15285793
J Clin Endocrinol Metab. 2005 Feb;90(2):992-1000
pubmed: 15562014
J Biol Chem. 2002 Feb 22;277(8):6025-31
pubmed: 11744699
Mol Immunol. 2010 Mar;47(6):1244-54
pubmed: 20116105
Science. 2001 Oct 12;294(5541):333-9
pubmed: 11598293
J Neuroimmunol. 2004 Nov;156(1-2):146-52
pubmed: 15465605
Genes Dev. 1994 Mar 1;8(5):538-53
pubmed: 7926749
Endocrinology. 2004 Nov;145(11):5157-67
pubmed: 15297446
J Clin Endocrinol Metab. 1985 Jun;60(6):1210-5
pubmed: 3998066
Eur J Pharmacol. 2006 Mar 18;534(1-3):258-63
pubmed: 16612844
J Biol Rhythms. 2006 Oct;21(5):350-61
pubmed: 16998155
Science. 1989 Sep 8;245(4922):1118-21
pubmed: 2570461
Science. 2002 Aug 2;297(5582):843-5
pubmed: 12161655
Cell. 2015 Sep 24;163(1):84-94
pubmed: 26406372
Science. 2000 Nov 24;290(5496):1574-7
pubmed: 11090355
Cell. 1999 Jul 23;98(2):193-205
pubmed: 10428031
J Neurosci. 2014 Sep 3;34(36):11929-47
pubmed: 25186741
J Auton Nerv Syst. 1992 Nov;41(1-2):87-92
pubmed: 1491118
Nat Immunol. 2007 Oct;8(10):1123-31
pubmed: 17828268
Trends Neurosci. 2018 Apr;41(4):211-223
pubmed: 29475564
J Clin Invest. 2002 Mar;109(6):765-75
pubmed: 11901185
Brain Behav Immun. 2002 Aug;16(4):290-332
pubmed: 12096881
J Clin Endocrinol Metab. 1946 Apr;6:287-94
pubmed: 21025121
J Immunol. 1997 Nov 15;159(10):4857-67
pubmed: 9366411
Nature. 1976 Dec 16;264(5587):656-8
pubmed: 826835
J Immunol. 1997 May 1;158(9):4200-10
pubmed: 9126981
J Physiol. 1994 Mar 15;475(3):539-45
pubmed: 8006835
Front Biosci. 2005 Sep 01;10:2217-29
pubmed: 15970488
Mol Cell Biochem. 1996 Oct-Nov;163-164:159-65
pubmed: 8974052
Sci Transl Med. 2019 Oct 9;11(513):
pubmed: 31597755
Circ Res. 1996 May;78(5):737-49
pubmed: 8620593
Proc Soc Exp Biol Med. 1950 Dec;75(3):846-7
pubmed: 14808426
Mol Pharmacol. 2009 Nov;76(5):935-41
pubmed: 19684092
Endocrinology. 2000 Oct;141(10):3832-41
pubmed: 11014240
Immunity. 2018 Dec 18;49(6):1175-1190.e7
pubmed: 30527911
Cell Rep. 2019 Mar 19;26(12):3191-3202.e8
pubmed: 30893593
J Immunol. 2010 Nov 15;185(10):5762-8
pubmed: 20935206
J Exp Med. 2014 Dec 15;211(13):2583-98
pubmed: 25422496
Trends Endocrinol Metab. 2008 Jul;19(5):175-80
pubmed: 18394919
Eur J Neurosci. 2005 Feb;21(3):814-9
pubmed: 15733101
Nat Neurosci. 2019 Nov;22(11):1782-1792
pubmed: 31636451
Cell Rep. 2015 Jun 9;11(9):1339-49
pubmed: 26004187
Front Endocrinol (Lausanne). 2018 Dec 04;9:711
pubmed: 30564193
Nat Neurosci. 2019 Nov;22(11):1771-1781
pubmed: 31636449
Comp Biochem Physiol. 1964 Apr;11:393-409
pubmed: 14167535
Nature. 2010 Aug 12;466(7308):829-34
pubmed: 20703299
J Neuroimmunol. 1997 Apr;74(1-2):159-64
pubmed: 9119969
Nat Rev Mol Cell Biol. 2020 Feb;21(2):67-84
pubmed: 31768006
J Neurosci. 1988 May;8(5):1767-75
pubmed: 2896766
Br J Psychiatry. 1980 Jun;136:533-41
pubmed: 6155966
J Neurochem. 1977 Mar;28(3):677-9
pubmed: 404398
Science. 2005 Apr 22;308(5721):512-7
pubmed: 15845844
Physiol Behav. 1987;40(3):323-8
pubmed: 3659148
Mol Endocrinol. 1992 Nov;6(11):1951-60
pubmed: 1480181
Blood. 2006 Jul 15;108(2):518-24
pubmed: 16609073
Cell Stem Cell. 2018 Oct 4;23(4):572-585.e7
pubmed: 30174297
J Endocrinol. 1990 Jul;126(1):5-8
pubmed: 2166125
J Anat. 1993 Dec;183 ( Pt 3):601-7
pubmed: 8300437
Cell Metab. 2005 Nov;2(5):297-307
pubmed: 16271530
Pharmacol Rev. 2000 Dec;52(4):595-638
pubmed: 11121511
J Neurosci. 2000 Oct 15;20(20):7830-7
pubmed: 11027248
Nat Genet. 2002 Jul;31(3):311-5
pubmed: 12068299
J Neuroimmunol. 2007 May;186(1-2):27-36
pubmed: 17428548
FASEB J. 1988 Aug;2(11):2686-95
pubmed: 2840317
J Exp Med. 2016 Nov 14;213(12):2567-2574
pubmed: 27799619
Acta Physiol Scand Suppl. 1979;469:1-48
pubmed: 293120
J Comp Neurol. 1972 Sep;146(1):1-14
pubmed: 4116104
Best Pract Res Clin Endocrinol Metab. 2001 Dec;15(4):495-511
pubmed: 11800520
Int J Cancer. 1991 Sep 9;49(2):178-81
pubmed: 1652566
Cell. 1999 Jan 22;96(2):271-90
pubmed: 9988221
Trends Biochem Sci. 2000 Dec;25(12):601-6
pubmed: 11116186
Brain Res. 1972 Jul 13;42(1):201-6
pubmed: 5047187
Neuron. 2004 Aug 19;43(4):527-37
pubmed: 15312651
Life Sci. 1977 Sep 1;21(5):595-606
pubmed: 20542
Proc Natl Acad Sci U S A. 1987 Nov;84(22):7920-4
pubmed: 2825170
Endocrinology. 1956 Mar;58(3):365-75
pubmed: 13294085
J Anat. 1993 Oct;183 ( Pt 2):291-307
pubmed: 8300417
Proc Assoc Am Physicians. 1996 Sep;108(5):374-81
pubmed: 8902882
J Immunol. 1985 Aug;135(2 Suppl):755s-765s
pubmed: 2861231
Brain Res Bull. 1994;35(5-6):607-16
pubmed: 7859118
Immunity. 2017 Jan 17;46(1):120-132
pubmed: 28087238
Am J Physiol. 1953 Jul;174(1):109-22
pubmed: 13065505
J Neuroimmunol. 1995 Sep;61(2):123-31
pubmed: 7593548
Neuroscience. 1999;94(1):141-50
pubmed: 10613504
Physiol Rev. 1983 Jul;63(3):844-914
pubmed: 6308694
Basic Res Cardiol. 1990;85 Suppl 1:9-30
pubmed: 2091611
Sleep. 2006 Oct;29(10):1327-36
pubmed: 17068987
Neuron. 2015 Aug 5;87(3):605-20
pubmed: 26212712
Science. 1975 Jul 4;189(4196):55-8
pubmed: 1094539
Physiol Behav. 1993 Sep;54(3):555-61
pubmed: 8415950
Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13468-73
pubmed: 10557344
J Neuroendocrinol. 2008 Mar;20(3):323-9
pubmed: 18208549
Proc Natl Acad Sci U S A. 1980 May;77(5):3033-7
pubmed: 6771765
Pharmacol Rev. 2003 Jun;55(2):325-95
pubmed: 12773631
Cell Stem Cell. 2015 Jul 2;17(1):89-100
pubmed: 26095046
Science. 1943 Oct 22;98(2547):367-9
pubmed: 17748288
Brain Res Bull. 1987 Jul;19(1):135-9
pubmed: 3651837
Cell. 1999 Jan 8;96(1):57-68
pubmed: 9989497
Life Sci. 1989;45(4):275-82
pubmed: 2761344
Brain Res Mol Brain Res. 2005 Sep 13;139(1):129-36
pubmed: 15963600
Blood. 2019 Jan 17;133(3):224-236
pubmed: 30361261
Science. 1998 Jun 5;280(5369):1564-9
pubmed: 9616112
Z Zellforsch Mikrosk Anat. 1972;135(1):1-26
pubmed: 4629413
Nat Struct Mol Biol. 2005 May;12(5):441-8
pubmed: 15821743
Science. 1990 Feb 23;247(4945):975-8
pubmed: 2305266
Biochem Biophys Res Commun. 1984 May 31;121(1):1-7
pubmed: 6145413
Life Sci. 1980 Apr 14;26(15):1183-94
pubmed: 6248704
Anat Rec. 1981 Apr;199(4):531-42
pubmed: 6168212
Eur J Neurosci. 1999 May;11(5):1535-44
pubmed: 10215906
J Neurosci. 1991 Jul;11(7):2087-101
pubmed: 1676727
Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8570-8575
pubmed: 30971490
Science. 2013 Nov 8;342(6159):727-30
pubmed: 24202171
Science. 1974 Apr 12;184(4133):163-5
pubmed: 4815721
Neuroendocrinology. 1992 Jan;55(1):74-83
pubmed: 1319007
Acta Physiol Scand. 1954 Jun 21;31(1):1-5
pubmed: 13188719
Nat Neurosci. 2001 Jul;4(7):732-8
pubmed: 11426230
J Biol Chem. 1966 May 25;241(10):2301-5
pubmed: 4287854
Nature. 2008 Mar 27;452(7186):442-7
pubmed: 18256599
J Anat. 1989 Apr;163:173-81
pubmed: 2606772
J Auton Pharmacol. 1980 Nov;1(1):101-6
pubmed: 6122687
Science. 1965 Dec 10;150(3702):1464-5
pubmed: 4285299
J Pineal Res. 2013 Mar;54(2):162-9
pubmed: 22812624
Proc Natl Acad Sci U S A. 1998 May 12;95(10):5474-9
pubmed: 9576906
Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6072-E6079
pubmed: 27688755
Trends Pharmacol Sci. 1988 Mar;9(3):102-7
pubmed: 3072735
Mol Cell Endocrinol. 2012 Feb 5;349(1):20-9
pubmed: 21782883
J Biol Rhythms. 2005 Oct;20(5):391-403
pubmed: 16267379
J Immunol. 2000 Dec 15;165(12):6743-7
pubmed: 11120793
Cell Signal. 2007 Feb;19(2):251-60
pubmed: 16996249
Clin Exp Immunol. 1997 Dec;110(3):500-8
pubmed: 9409657
J Allergy Clin Immunol. 2000 Jan;105(1 Pt 1):91-8
pubmed: 10629458
Neuropathol Appl Neurobiol. 1983 Jan-Feb;9(1):3-19
pubmed: 6133229
Immunity. 2012 Aug 24;37(2):290-301
pubmed: 22863835
Blood. 2009 May 21;113(21):5134-43
pubmed: 19293427
Biol Psychol. 1975;2(3):175-88
pubmed: 1139017
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5428-33
pubmed: 10779554
J Auton Nerv Syst. 1984 Sep;11(2):125-44
pubmed: 6386942
Brain Behav Immun. 2012 Feb;26(2):195-200
pubmed: 21855626
Regul Pept. 1994 May 26;51(3):221-7
pubmed: 7938706
Cell. 2006 Jan 27;124(2):407-21
pubmed: 16439213
J Neuroinflammation. 2019 Dec 17;16(1):266
pubmed: 31847911