Androgen Receptors in Epithelial Cells Regulate Thymopoiesis and Recent Thymic Emigrants in Male Mice.
T cells
androgens
mice
thymic epithelial cells
thymus
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
09
2019
accepted:
26
05
2020
entrez:
28
7
2020
pubmed:
28
7
2020
medline:
7
4
2021
Statut:
epublish
Résumé
Androgens have profound effects on T cell homeostasis, including regulation of thymic T lymphopoiesis (thymopoiesis) and production of recent thymic emigrants (RTEs), i. e., immature T cells that derive from the thymus and continue their maturation to mature naïve T cells in secondary lymphoid organs. Here we investigated the androgen target cell for effects on thymopoiesis and RTEs in spleen and lymph nodes. Male mice with a general androgen receptor knockout (G-ARKO), T cell-specific (T-ARKO), or epithelial cell-specific (E-ARKO) knockout were examined. G-ARKO mice showed increased thymus weight and increased numbers of thymic T cell progenitors. These effects were not T cell-intrinsic, since T-ARKO mice displayed unaltered thymus weight and thymopoiesis. In line with a role for thymic epithelial cells (TECs), E-ARKO mice showed increased thymus weight and numbers of thymic T cell progenitors. Further, E-ARKO mice had more CD4
Identifiants
pubmed: 32714327
doi: 10.3389/fimmu.2020.01342
pmc: PMC7344216
doi:
Substances chimiques
Receptors, Androgen
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1342Subventions
Organisme : NIAID NIH HHS
ID : R01 AI064318
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI132960
Pays : United States
Informations de copyright
Copyright © 2020 Wilhelmson, Lantero Rodriguez, Johansson, Svedlund Eriksson, Stubelius, Lindgren, Fagman, Fink, Carlsten, Ekwall and Tivesten.
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