The Construction and Comprehensive Prognostic Analysis of the LncRNA-Associated Competitive Endogenous RNAs Network in Colorectal Cancer.
ceRNA network
colorectal cancer
differentially expressed RNAs
nomogram
overall survival
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
01
2020
accepted:
13
05
2020
entrez:
28
7
2020
pubmed:
28
7
2020
medline:
28
7
2020
Statut:
epublish
Résumé
Competing endogenous RNAs (ceRNAs) are a newly proposed RNA interaction mechanism that has been associated with the tumorigenesis, metastasis, diagnosis, and predicting survival of various cancers. In this study, we constructed a ceRNA network in colorectal cancer (CRC). Then, we sought to develop and validate a composite clinicopathologic-genomic nomogram using The Cancer Genome Atlas (TCGA) database. To construct the ceRNA network in CRC, we analyzed the mRNAseq, miRNAseq data, and clinical information from TCGA database. LncRNA, miRNA, and mRNA signatures were identified to construct risk score as independent indicators of the prognostic value in CRC patients. A composite clinicopathologic-genomic nomogram was developed to predict the overall survival (OS). One hundred sixty-one CRC-specific lncRNAs, 97 miRNAs, and 161 mRNAs were identified to construct the ceRNA network. Multivariate Cox proportional hazards regression analysis indicated that nine-lncRNA signatures, eight-miRNA signatures, and five-mRNA signatures showed a significant prognostic value for CRC. Furthermore, a clinicopathologic-genomic nomogram was constructed in the primary cohort, which performed well in both the primary and validation sets. This study presents a nomogram that incorporates the CRC-specific ceRNA expression profile, clinical features, and pathological factors, which demonstrate its excellent differentiation and risk stratification in predicting OS in CRC patients.
Identifiants
pubmed: 32714366
doi: 10.3389/fgene.2020.00583
pmc: PMC7344331
doi:
Types de publication
Journal Article
Langues
eng
Pagination
583Informations de copyright
Copyright © 2020 Li, Yu, Jiang, Gao, Wang, Jin, Zhao and Liu.
Références
PLoS One. 2018 Feb 8;13(2):e0192494
pubmed: 29420609
Nucleic Acids Res. 2019 Jan 8;47(D1):D745-D751
pubmed: 30407521
Mol Cell. 2014 Jun 5;54(5):766-76
pubmed: 24793693
Nat Genet. 2000 May;25(1):25-9
pubmed: 10802651
Biochem Biophys Res Commun. 2015 May 1;460(2):314-9
pubmed: 25778865
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Front Oncol. 2019 Nov 08;9:1181
pubmed: 31781492
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
J Exp Clin Cancer Res. 2014 Dec 31;33:113
pubmed: 25551793
Nature. 2014 Jan 16;505(7483):344-52
pubmed: 24429633
Clin Cancer Res. 2015 Aug 15;21(16):3578-80
pubmed: 26275951
Int J Cancer. 2015 Mar 1;136(5):E359-86
pubmed: 25220842
J Cell Biochem. 2018 Apr;119(4):3574-3585
pubmed: 29227531
Onco Targets Ther. 2017 Feb 22;10:1017-1026
pubmed: 28260919
Carcinogenesis. 2019 Jul 20;40(7):861-870
pubmed: 30933267
Transl Oncol. 2018 Oct;11(5):1202-1212
pubmed: 30075461
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
Nature. 2001 Feb 15;409(6822):814-6
pubmed: 11236992
Dose Response. 2019 Dec 11;17(4):1559325819894179
pubmed: 31853237
Oncotarget. 2017 Dec 19;9(31):21687-21695
pubmed: 29774095
Carcinogenesis. 2019 Nov 30;:
pubmed: 31784750
J Cancer. 2016 Jan 01;7(2):214-24
pubmed: 26819646
J Transl Med. 2015 Jul 17;13:231
pubmed: 26183581
Sci Rep. 2019 Feb 12;9(1):1803
pubmed: 30755640
Trends Genet. 2015 May;31(5):239-51
pubmed: 25869999
Physiol Rev. 2016 Oct;96(4):1297-325
pubmed: 27535639
Gastroenterology. 2018 Jun;154(8):2152-2164.e19
pubmed: 29458155
Sci Rep. 2016 Dec 12;6:39028
pubmed: 27941905
Mol Cancer. 2015 Nov 04;14:184
pubmed: 26536864
Cell. 2011 Aug 5;146(3):353-8
pubmed: 21802130
Mol Cancer Res. 2018 Sep;16(9):1373-1384
pubmed: 29784666
J Natl Cancer Inst. 2020 Apr 1;112(4):356-368
pubmed: 31286138
Eur Rev Med Pharmacol Sci. 2017 May;21(9):2103-2107
pubmed: 28537675
Int J Oncol. 2017 Oct;51(4):1331-1342
pubmed: 28902363
Mol Oncol. 2017 Nov;11(11):1544-1560
pubmed: 28796930
J Clin Oncol. 2008 Mar 10;26(8):1364-70
pubmed: 18323559
Clin Cancer Res. 2004 Nov 1;10(21):7252-9
pubmed: 15534099
Epigenetics. 2013 Dec;8(12):1373-83
pubmed: 24149323
Neurobiol Dis. 2013 Oct;58:123-31
pubmed: 23726844
Aging (Albany NY). 2020 Jan 11;12(1):35-52
pubmed: 31926112
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D277-80
pubmed: 14681412
Oncol Rep. 2017 Oct;38(4):2043-2050
pubmed: 28902367
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Genomics Proteomics Bioinformatics. 2016 Feb;14(1):42-54
pubmed: 26883671
J Exp Clin Cancer Res. 2014 Oct 06;33:84
pubmed: 25288503
J Cell Biochem. 2019 Apr;120(4):6078-6089
pubmed: 30362160
Sci Rep. 2018 Apr 18;8(1):6157
pubmed: 29670141
Anticancer Res. 2015 Mar;35(3):1385-8
pubmed: 25750289
J Clin Oncol. 2013 Mar 20;31(9):1188-95
pubmed: 23358969
Oncotarget. 2016 Sep 27;7(39):64148-64167
pubmed: 27580177
Mol Cancer. 2017 Oct 17;16(1):162
pubmed: 29041935
Cell Death Dis. 2019 Jul 4;10(7):514
pubmed: 31273190