Severity of postgastrectomy syndrome and quality of life after advanced gastric cancer radical gastrectomy.
distal gastrectomy
gastric cancer
postgastrectomy syndrome
quality of life
Journal
Molecular and clinical oncology
ISSN: 2049-9450
Titre abrégé: Mol Clin Oncol
Pays: England
ID NLM: 101613422
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
23
01
2020
accepted:
12
05
2020
entrez:
28
7
2020
pubmed:
28
7
2020
medline:
28
7
2020
Statut:
ppublish
Résumé
It has previously been suggested that postgastrectomy syndrome (PGS) is more severe in patients after surgery for advanced gastric cancer than in patients with early gastric cancer. Using the postgastrectomy syndrome assessment scale-45 (PGSAS-45), the present study aimed to determine whether PGS for postgastrectomy patients, in Kanazawa Medical University Hospital, with advanced gastric cancer was more severe than for patients with early gastric cancer. A questionnaire survey was conducted using PGSAS-45 for curative gastric cancer gastrectomy cases at Kanazawa Medical University Hospital. The questionnaire data were combined with patient background data, anonymized and moved to an unlinked file for patient privacy. Using this dataset, non-recurrent cases of distal partial gastrectomy were extracted and divided into two groups, stage IA or IB patients (group E), and stage IIA or higher (group A). The main outcome measures (MOMs) of PGSAS-45 were compared between the two groups. The participants in the present study included 35 cases in group E and 22 cases in group A. The results of a univariate analysis to compare the MOMs between the two groups showed that only the dumping subscale was significantly different in group A and was judged to be caused by the underlying bias of the background factor. There were no MOMs with significant differences in the pathological stage based on multiple regression analyses. In cases of distal partial gastrectomy, the PGS and quality of life (QoL) of patients following advanced gastric cancer surgery were similar to those of patients with early gastric cancer. The standardized treatment for advanced gastric cancer did not induce notable postoperative failures, and QoL was not impaired. In contrast, for early-stage gastric cancer cases, the present study suggests that it is necessary to distinguish metastasis-negative cases to indicate an appropriate, function-preserving curative gastrectomy.
Identifiants
pubmed: 32714536
doi: 10.3892/mco.2020.2061
pii: MCO-0-0-2061
pmc: PMC7366243
doi:
Types de publication
Journal Article
Langues
eng
Pagination
133-140Informations de copyright
Copyright: © Kinami et al.
Références
Ann Surg Oncol. 2014 Jun;21 Suppl 3:S370-8
pubmed: 24590434
Surg Endosc. 2008 Sep;22(9):2003-8
pubmed: 18594924
Gastric Cancer. 2017 Mar;20(Suppl 1):53-59
pubmed: 27714472
Nihon Geka Gakkai Zasshi. 1996 Apr;97(4):286-90
pubmed: 8692145
Int J Surg. 2013;11 Suppl 1:S104-9
pubmed: 24380539
World J Gastroenterol. 2016 Oct 28;22(40):8978-8990
pubmed: 27833389
J Clin Oncol. 2011 Nov 20;29(33):4387-93
pubmed: 22010012
Gastroenterol Clin North Am. 1994 Jun;23(2):261-79
pubmed: 8070912
World J Clin Cases. 2018 Dec 26;6(16):1111-1120
pubmed: 30613669
Hepatogastroenterology. 2008 Mar-Apr;55(82-83):496-9
pubmed: 18613395
Niger J Clin Pract. 2019 May;22(5):661-668
pubmed: 31089021
Surg Clin North Am. 2017 Apr;97(2):277-293
pubmed: 28325187
Oncol Lett. 2016 Jun;11(6):4055-4062
pubmed: 27313740
Surg Today. 2017 Jun;47(6):651-659
pubmed: 27342746
Bone Marrow Transplant. 2013 Mar;48(3):452-8
pubmed: 23208313
Transl Gastroenterol Hepatol. 2017 May 09;2:42
pubmed: 28616598
World J Gastroenterol. 2019 Apr 14;25(14):1640-1652
pubmed: 31011251
Gastric Cancer. 2015 Jan;18(1):147-58
pubmed: 24515247
Surg Clin North Am. 2011 Oct;91(5):1105-22
pubmed: 21889032
Acta Med Okayama. 2016;70(2):119-30
pubmed: 27094837
Dig Dis Sci. 1988 Feb;33(2):129-34
pubmed: 3123181