The Inflammatory and Foreign Body Reaction of Polymethyl Methacrylate Glaucoma Drainage Device in the Rabbit Eye.
foreign body reaction
glaucoma drainage device
inflammatory reaction
polymethyl methacrylate
Journal
Translational vision science & technology
ISSN: 2164-2591
Titre abrégé: Transl Vis Sci Technol
Pays: United States
ID NLM: 101595919
Informations de publication
Date de publication:
18 02 2020
18 02 2020
Historique:
entrez:
28
7
2020
pubmed:
28
7
2020
medline:
28
7
2020
Statut:
epublish
Résumé
To assess the safety and tissue response of a polymethyl methacrylate (PMMA) glaucoma drainage device (GDD) in the rabbit eye. Specially constructed PMMA GDD devices were implanted into rabbit eyes and evaluated histopathologically following euthanasia on days 5, 30, and 60 after implantation surgery. Hematoxylin-eosin, Masson's trichrome, and periodic acid-Schiff were used to stain tissue specimens dissected from the surgical site. Inflammatory cell count and capsule thickness measurements were performed. Three rabbits were sacrificed on day 5, 3 on day 30, and 4 on day 60. Macrophage and lymphocyte counts increased from day 5 to day 30 then decreased ( Histopathologically, the inflammatory response toward this PMMA glaucoma drainage device was comparable to other reported GDDs. No accentuated response or adverse event was seen suggesting that PMMA may be useful as a GDD material. An affordable, locally built GDD is needed in Indonesia because of the high prevalence of severe glaucoma. This rabbit study is a significant step toward justifying the use of PMMA as a GDD material. PMMA is cheap and easily manufactured and sterilized in developing economies.
Identifiants
pubmed: 32714646
doi: 10.1167/tvst.9.3.20
pii: TVST-19-1680
pmc: PMC7352041
doi:
Substances chimiques
Polymethyl Methacrylate
9011-14-7
Types de publication
Journal Article
Langues
eng
Pagination
20Informations de copyright
Copyright 2020 The Authors.
Déclaration de conflit d'intérêts
Disclosure: V.D. Oktariana Asrory, None; R. Sitompul, None; W. Artini, None; S. Estuningsih, None; D. Noviana, None; W.H. Morgan, None
Références
Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1187-97
pubmed: 18978350
Br J Ophthalmol. 1969 Mar;53(3):161-8
pubmed: 5813407
Korean J Ophthalmol. 1990 Dec;4(2):73-81
pubmed: 2092164
Arch Ophthalmol. 2000 Aug;118(8):1081-4
pubmed: 10922202
Br J Ophthalmol. 1999 Oct;83(10):1168-71
pubmed: 10502580
Invest Ophthalmol Vis Sci. 2013 Jun 06;54(6):3957-64
pubmed: 23674756
Eye (Lond). 2006 May;20(5):606-10
pubmed: 15999134
Ophthalmic Res. 2014;51(3):129-39
pubmed: 24503529
Invest Ophthalmol Vis Sci. 2014 Mar 25;55(3):1848-52
pubmed: 24557347
Ophthalmic Surg Lasers. 1999 Sep-Oct;30(8):662-7
pubmed: 10507569
Cell Mol Life Sci. 2003 Nov;60(11):2334-46
pubmed: 14625680
Semin Immunol. 2008 Apr;20(2):86-100
pubmed: 18162407
J Mater Chem B. 2016;4:1586-1599
pubmed: 27630769
Acta Cir Bras. 2005 Jul-Aug;20(4):284-91
pubmed: 16186947
Nat Mater. 2015 Jun;14(6):643-51
pubmed: 25985456
Curr Opin Hematol. 2009 Jan;16(1):53-7
pubmed: 19057205
Invest Ophthalmol Vis Sci. 2012 Oct 05;53(11):6914-9
pubmed: 22956615