Qualitative and Quantitative Analysis of B-Cell-Produced Antibodies in Vitreous Humor of Type 2 Diabetic Patients with Diabetic Retinopathy.
Journal
Journal of diabetes research
ISSN: 2314-6753
Titre abrégé: J Diabetes Res
Pays: England
ID NLM: 101605237
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
02
2020
revised:
21
04
2020
accepted:
13
05
2020
entrez:
28
7
2020
pubmed:
28
7
2020
medline:
10
6
2021
Statut:
epublish
Résumé
To analyze the levels of B-cell-produced antibodies in the vitreous humor of patients with or without diabetic retinopathy (DR) both qualitatively and quantitatively. A total of 52 type 2 diabetes mellitus (T2DM) with DR patients and 52 control subjects without diabetes mellitus or inflammatory diseases were included in this prospective study. The levels of immunoglobulin (Ig)A, IgM, and IgG subtypes were measured using a magnetic color-bead-based multiplex assay. The concentrations of IgA, IgM, and total antibodies in the DR group were significantly higher than those in the control group (all Increased levels of IgA, IgM, and total antibodies produced by B cells were observed in the vitreous humor of T2DM patients with DR. There were low negative correlations between levels of antibodies (IgA, IgM) and eGFR.
Identifiants
pubmed: 32714992
doi: 10.1155/2020/4631290
pmc: PMC7352131
doi:
Substances chimiques
Immunoglobulin A
0
Immunoglobulin G
0
Immunoglobulin M
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4631290Informations de copyright
Copyright © 2020 Baoyi Liu et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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