Disrupted white matter functional connectivity in aMCI APOEε4 carriers: a resting-state study.
Apolipoprotein E
Functional connectivity
Mild cognitive impairment
White matter
fMRI
Journal
Brain imaging and behavior
ISSN: 1931-7565
Titre abrégé: Brain Imaging Behav
Pays: United States
ID NLM: 101300405
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
pubmed:
28
7
2020
medline:
7
9
2021
entrez:
28
7
2020
Statut:
ppublish
Résumé
The ε4 allele of the APOE gene is thought to increase risk from amnestic mild cognitive impairment (aMCI) to Alzheimer's disease. Cognitive decline in the condition is increasingly considered to worsen functional disconnections in brain network composed of gray matter and white matter. Nevertheless, Whether APOEε4 targets specific white matter functional connectivity in patients with aMCI remains mostly unexplored, mainly due to the challenges of detecting BOLD signals in white matter. Here, we applied a novel approach to investigate APOEε4-related specific bundles and cortical area alterations in aMCI subjects, in order to characterize white matter-gray matter functional connectivity differences throughout the brain. We analyzed 75 patients with aMCI and 76 demographically matched normal controls. The aMCI APOEε4 carriers showed decreased functional connectivity located at left corticospinal tract, bilateral posterior limb of internal capsule, and right temporopolaris, which was different from the regions of aMCI-related changes. We further found that recognition scores were positively associated with the right temporopolaris in aMCI APOEε4 carriers. Collectively, the data provide new evidence that APOEε4 genotype exerts a negative impact on neural activity in both gray and white matter in aMCI, which potentially contributes to functional disconnection and memory decline. A novel method provides full-scale measuring effect of disease conditions on functional architecture throughout the brain. Trial registration: https://www.ClinicalTrials.gov (Identifier: NCT02225964). Registered January 2014.
Identifiants
pubmed: 32715396
doi: 10.1007/s11682-020-00367-7
pii: 10.1007/s11682-020-00367-7
doi:
Banques de données
ClinicalTrials.gov
['NCT02225964']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1739-1747Subventions
Organisme : National Key Research and Development Program of China
ID : 2016YFC1306300, 2018YFC1312001
Organisme : National Natural Science Foundation of China
ID : 61633018
Organisme : National Natural Science Foundation of China
ID : 81871438
Informations de copyright
© 2020. Springer Science+Business Media, LLC, part of Springer Nature.
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