Mast cell tumours in dogs less than 12 months of age: a multi-institutional retrospective study.
Journal
The Journal of small animal practice
ISSN: 1748-5827
Titre abrégé: J Small Anim Pract
Pays: England
ID NLM: 0165053
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
29
08
2019
revised:
24
03
2020
accepted:
20
04
2020
entrez:
28
7
2020
pubmed:
28
7
2020
medline:
20
9
2020
Statut:
ppublish
Résumé
To describe the clinicopathological and genetic characteristics of mast cell tumours in dogs less than 12 months old. Retrospective review of dogs aged less than 12 months when diagnosed with mast cell tumours at three referral hospitals in the UK. Sixteen pure-bred dogs were included, of which 11 were female. The median age at first presentation and diagnosis were 7.6 and 9 months, respectively. In 13 dogs the mast cell tumours were cutaneous and in three they were subcutaneous. Four cutaneous mast cell tumours were described as high-grade (Patnaik or Kiupel) and nine were Patnaik grade II; three had mitotic index of >5 in 10 high-power fields. Of the three subcutaneous tumours, two had an infiltrative growth pattern and one had mitotic index of 10 per 10 high-power fields. Of 10 tested dogs, seven had c-kit mutations in exon 11 and Ki-67 score was above the cut-off value in nine. Four of 12 cases showed evidence of metastasis in the regional lymph nodes. After varying treatment protocols, all patients were alive and disease free at a median of 1115 days after diagnosis. The prognosis of mast cell tumours in dogs less than a year old appears better than the adult counterparts, even without extensive treatment.
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
449-457Informations de copyright
© 2020 British Small Animal Veterinary Association.
Références
Abadie, J. J. , Amardeilh, M. A. & Delverdier, M. E. (1999) Immunohistochemical detection of proliferating cell nuclear antigen and Ki-67 in mast cell tumors from dogs. Journal of the American Veterinary Medical Association 215(11), 1629-1634
Berlato, D. , Stewart, J. , Newton, R. , et al. (2012) Evaluation of minichromosome maintenance protein 7 as a prognostic marker in canine cutaneous mast cell tumours. Veterinary and Comparative Oncology 10, 135-142. https://doi.org/10.1111/j.1476-5829.2011.00287.x
Berlato, D. , Murphy, S. & Monti, P. , et al. (2015) Comparison of mitotic index and Ki67 index in the prognostication of canine cutaneous mast cell tumours. Veterinary and Comparative Oncology 13(2), 143-150. https://doi.org/10.1111/vco.12029
Berlato, D. , Murphy, S. & Laberke, S. , et al. (2018) Comparison of minichromosome maintenance protein 7, Ki67 and mitotic index in the prognosis of intermediate Patnaik grade cutaneous mast cell tumours in dogs. Veterinary and Comparative Oncology 16(4), 535-543. https://doi.org/10.1111/vco.12412
Blackwood, L. , Murphy, S. , Buracco, P. , et al. (2012) European consensus document on mast cell tumours in dogs and cats. Veterinary and Comparative Oncology 10, e1-e29. https://doi.org/10.1111/j.1476-5829.2012.00341.x
Bodemer, C. , Hermine, O. , Palmérini, F. , et al. (2010) Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations. The Journal of Investigative Dermatology 130, 804-815. https://doi.org/10.1038/jid.2009.281
Castells, M. , Metcalfe, D. D. & Escribano, L. (2011) Diagnosis and treatment of cutaneous mastocytosis in children: practical recommendations. American Journal of Clinical Dermatology 12, 259-270. https://doi.org/10.2165/11588890-000000000-00000
Coolen, N. A. , Schouten, K. C. W. M. , Middelkoop, E. , et al. (2010) Comparison between human fetal and adult skin. Archives of Dermatological Research 302, 47-55. https://doi.org/10.1007/s00403-009-0989-8
Davis, B. J. , Page, R. , Sannes, P. L. , et al. (1992) Cutaneous mastocytosis in a dog. Veterinary Pathology 29, 363-365. https://doi.org/10.1177/030098589202900415
Dobson, J. (2013) Breed-predispositions to cancer in pedigree dogs. ISRN Veterinary Science 2013, 941275-941223. https://doi.org/10.1155/2013/941275
Frieri, M. & Quershi, M. (2013) Pediatric Mastocytosis: a review of the literature. Pediatric Allergy, Immunology, and Pulmonology 26, 175-180. https://doi.org/10.1089/ped.2013.0275
Gieger, T. L. , Theon, A. P. , Werner, J. A. , et al. (2003) Biologic behavior and prognostic factors for mast cell tumors of the canine muzzle: 24 cases (1990-2001). Journal of Veterinary Internal Medicine 17, 687-692. https://doi.org/10.1111/j.1939-1676.2003.tb02501.x
Hannaford, R. & Rogers, M. (2001) Presentation of cutaneous mastocytosis in 173 children. Australasian Journal of Dermatology 42, 15-21. https://doi.org/10.1046/j.1440-0960.2001.00466.x
Horta, R. S. , Lavalle, G. E. & Monteiro, L. N. , et al. (2018) Assessment of canine mast cell tumor mortality risk based on clinical, histologic, immunohistochemical, and molecular features. Veterinary Pathology 55(2), 212-223. https://doi.org/10.1177/0300985817747325
Kiupel, M. , Webster, J. D. , Kaneene, J. B. , et al. (2004) The use of KIT and tryptase expression patterns as prognostic tools for canine cutaneous mast cell tumors. Veterinary Pathology 41, 371-377. https://doi.org/10.1354/vp.41-4-371
Kiupel, M. , Webster, J. D. , Bailey, K. L. , et al. (2011) Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior. Veterinary Pathology 48, 147-155. https://doi.org/10.1177/0300985810386469
van Lelyveld, S. , Warland, J. & Miller, R. , et al. (2015) Comparison between Ki-67 index and mitotic index for predicting outcome in canine mast cell tumours. Journal of Small Animal Practice 56(5), 312-319. https://doi.org/10.1111/jsap.12320
London, C. A. , Malpas, P. B. , Wood-Follis, S. L. , et al. (2009) Multi-center, placebo-controlled, double-blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision. Clinical Cancer Research 15, 3856-3865. https://doi.org/10.1158/1078-0432.CCR-08-1860
Ma, D. , Stence, A. A. , Bossler, A. B. , et al. (2014) Identification of KIT activating mutations in paediatric solitary mastocytoma. Histopathology 64, 218-225. https://doi.org/10.1111/his.12212
Mahler, S. (2012) Mast cell tumour in a young boxer dog. Veterinary Record 171, 182. https://doi.org/10.1136/vr.e5551
Méni, C. , Bruneau, J. & Georgin-Lavialle, S. , et al. (2015) Paediatric mastocytosis: a systematic review of 1747 cases. British Journal of Dermatology 172(3), 642-651. https://doi.org/10.1111/bjd.13567
Miller, D. M. (1995) The occurrence of mast cell tumors in young Shar-Peis. Journal of Veterinary Diagnostic Investigation 7, 360-363. https://doi.org/10.1177/104063879500700311
Patnaik, A. K. , Ehler, W. J. & Macewen, E. G. (1984) Canine cutaneous mast cell tumor: morphologic grading and survival time in 83 dogs. Veterinary Pathology 21, 469-474
Pratschke, K. M., Atherton, M. J. & Sillito, J. A., et al. (2013) Evaluation of a modified proportional margins approach for surgical resection of mast cell tumors in dogs: 40 cases (2008-2012). Journal of the American Veterinary Medical Association 243(10), 1436-1441. https://doi.org/10.2460/javma.243.10.1436
Romansik, E. M. , Reilly, C. M. , Kass, P. H. , et al. (2007) Mitotic index is predictive for survival for canine cutaneous mast cell tumors. Veterinary Pathology 44, 335-341. https://doi.org/10.1354/vp.44-3-335
Scase, T. J. , Edwards, D. & Miller, J. , et al. (2006) Canine mast cell tumors: correlation of apoptosis and proliferation markers with prognosis. Journal of Veterinary Internal Medicine 20(1), 151-158. https://doi.org/10.1892/0891-6640(2006)20[151:cmctco]2.0.co;2
Schwab, T. M. , Popovitch, C. , DeBiasio, J. , et al. (2014) Clinical outcome for MCTs of canine pinnae treated with surgical excision (2004-2008). Journal of the American Animal Hospital Association 50, 187-191. https://doi.org/10.5326/JAAHA-MS-6039
Selmic, L. E. & Ruple, A. (2020) A systematic review of surgical margins utilized for removal of cutaneous mast cell tumors in dogs. BMC Veterinary Research 16, 5. https://doi.org/10.1186/s12917-019-2227-8
Shoop, S. J. , Marlow, S. , Church, D. B. , et al. (2015) Prevalence and risk factors for mast cell tumours in dogs in England. Canine Genetics and Epidemiology 2, 1. https://doi.org/10.1186/2052-6687-2-1
Simoes, J. P. , Schoning, P. & Butine, M. (1994) Prognosis of canine mast cell tumors: a comparison of three methods. Veterinary Pathology 31(6), 637-647. https://doi.org/10.1177/030098589403100602
Smith, J. , Kiupel, M. & Farrelly, J. , et al. (2017) Recurrence rates and clinical outcome for dogs with grade II mast cell tumours with a low AgNOR count and Ki67 index treated with surgery alone. Veterinary and Comparative Oncology 15(1), 36-45. https://doi.org/10.1111/vco.12140
Takeuchi, Y. , Fujino, Y. , Watanabe, M. , et al. (2013) Validation of the prognostic value of histopathological grading or c-kit mutation in canine cutaneous mast cell tumours: a retrospective cohort study. Veterinary Journal 196, 492-498. https://doi.org/10.1016/j.tvjl.2012.11.018
Thompson, J. J. , Yager, J. A. , & Best, S. J. , et al. (2010) Canine subcutaneous mast cell tumors. Veterinary Pathology 48(1), 169-181. https://doi.org/10.1177/0300985810390716
Thompson, J. J. , Pearl, D. L. , Yager, J. A. , et al. (2011) Canine subcutaneous mast cell tumor: characterization and prognostic indices. Veterinary Pathology 48, 156-168. https://doi.org/10.1177/0300985810387446
Villamil, J. A. , Henry, C. J. , Bryan, J. M. , et al. (2011) Identification of the most common cutaneous neoplasms in dogs and evaluation of breed and age distributions for selected neoplasms. Journal of the American Veterinary Medical Association 239(7), 960-965. https://doi.org/10.2460/javma.239.7.960
Warland, J. & Dobson, J. (2013) Breed predispositions in canine mast cell tumour: a single centre experience in the United Kingdom. Veterinary Journal 197, 496-498. https://doi.org/10.1016/j.tvjl.2013.02.017
Webster, J. D. , Yuzbasiyan-Gurkan, V. , Kaneene, J. B. , et al. (2006) The role of c-KIT in tumorigenesis: evaluation in canine cutaneous mast cell tumors. Neoplasia 8, 104-111. https://doi.org/10.1593/neo.05622
Webster, J. D. , Yuzbasiyan-Gurkan, V. , Miller, R. A. , et al. (2007) Cellular proliferation in canine cutaneous mast cell tumors: associations with c-KIT and its role in prognostication. Veterinary Pathology 44, 298-308. https://doi.org/10.1354/vp.44-3-298
Webster, J. D. , Yuzbasiyan-Gurkan, V. , Thamm, D. H. , et al. (2008) Evaluation of prognostic markers for canine mast cell tumors treated with vinblastine and prednisone. BMC Veterinary Research 4(32), 1-8. https://doi.org/10.1186/1746-6148-4-32
Weishaar, K. M. , Thamm, D. H. , Worley, D. R. , et al. (2014) Correlation of nodal mast cells with clinical outcome in dogs with mast cell tumour and a proposed classification system for the evaluation of node metastasis. Journal of Comparative Pathology 151, 329-338. https://doi.org/10.1016/j.jcpa.2014.07.004
Welle, M. M. , Bley, C. R. , & Howard, J. , et al. (2008) Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment. Veterinary Dermatology 19(6), 321-339. https://doi.org/10.1111/j.1365-3164.2008.00694.x
Yanagihori, H. , Oyama, N. , & Nakamura, K. , et al. (2005) c-kit Mutations in patients with childhood-onset mastocytosis and genotype-phenotype correlation. The Journal of Molecular Diagnostics 7(2), 252-257. https://doi.org/10.1016/S1525-1578(10)60552-1
Yang, Y. , Létard, S. , Borge, L. , et al. (2010) Pediatric mastocytosis-associated KIT extracellular domain mutations exhibit different functional and signaling properties compared with KIT-phosphotransferase domain mutations. Blood 116, 1114-1123. https://doi.org/10.1182/blood-2009-06-226027
Zemke, D. , Yamini, B. & Yuzbasiyan-Gurkan, V. (2002) Mutations in the juxtamembrane domain of c-KIT are associated with higher grade mast cell tumors in dogs. Veterinary Pathology 39, 529-535. https://doi.org/10.1354/vp.39-5-529