Migraine and Two-Pore-Domain Potassium Channels.
K2P channels
KCNK
Kozac sequence
allodynia
excitability
frameshift mutation-induced alternative translation initiation (fsATI)
heterodimerization
migraine
trigeminal sensory neurons
Journal
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
ISSN: 1089-4098
Titre abrégé: Neuroscientist
Pays: United States
ID NLM: 9504819
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
pubmed:
28
7
2020
medline:
18
1
2022
entrez:
28
7
2020
Statut:
ppublish
Résumé
Migraine is a common, disabling neurological disorder with a genetic, environmental, and hormonal component with an annual prevalence estimated at ~15%. It is characterized by attacks of severe, usually unilateral and throbbing headache, and can be accompanied by nausea, vomiting, and photophobia. Migraine is clinically divided into two main subtypes: migraine with aura, when it is preceded by transient neurological disturbances due to cortical spreading depression (CSD), and migraine without aura. Activation and sensitization of trigeminal sensory neurons, leading to the release of pro-inflammatory peptides, is likely a key component in headache pain initiation and transmission in migraine. In the present review, we will focus on the function of two-pore-domain potassium (K
Identifiants
pubmed: 32715910
doi: 10.1177/1073858420940949
doi:
Substances chimiques
Potassium Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM