Vitamin D insufficiency as a potential culprit in critical COVID-19 patients.
COVID-19
SARS-CoV-2
meta-analysis
outcome
vitamin D
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
22
06
2020
revised:
21
07
2020
accepted:
23
07
2020
pubmed:
28
7
2020
medline:
15
1
2021
entrez:
28
7
2020
Statut:
ppublish
Résumé
As an immune modulator, vitamin D has been implicated in the coronavirus disease-2019 (COVID-19) outcome. We aim to systematically explore the association of vitamin D serum levels with COVID-19 severity and prognosis. The standardized mean difference (SMD) or odds ratio and 95% confidence interval (CI) were applied to estimate pooled results from six studies. The prognostic performance of vitamin D serum levels for predicting adverse outcomes with detection of the best cutoff threshold was determined by receiver operating characteristic curve analysis. Decision tree analysis by combining vitamin D levels and clinical features was applied to predict severity in COVID-19 patients. Mean vitamin D serum level of 376 patients, was 21.9 nmol/L (95% CI = 15.36-28.45). Significant heterogeneity was found (I Serum vitamin D levels could be implicated in the COVID-19 prognosis. Diagnosis of vitamin D deficiency could be a helpful adjunct in assessing patients' potential of developing severe COVID-19. Appropriate preventative and/or therapeutic intervention may improve COVID-19 outcomes.
Sections du résumé
BACKGROUND
As an immune modulator, vitamin D has been implicated in the coronavirus disease-2019 (COVID-19) outcome. We aim to systematically explore the association of vitamin D serum levels with COVID-19 severity and prognosis.
METHODS
The standardized mean difference (SMD) or odds ratio and 95% confidence interval (CI) were applied to estimate pooled results from six studies. The prognostic performance of vitamin D serum levels for predicting adverse outcomes with detection of the best cutoff threshold was determined by receiver operating characteristic curve analysis. Decision tree analysis by combining vitamin D levels and clinical features was applied to predict severity in COVID-19 patients.
RESULTS
Mean vitamin D serum level of 376 patients, was 21.9 nmol/L (95% CI = 15.36-28.45). Significant heterogeneity was found (I
CONCLUSION
Serum vitamin D levels could be implicated in the COVID-19 prognosis. Diagnosis of vitamin D deficiency could be a helpful adjunct in assessing patients' potential of developing severe COVID-19. Appropriate preventative and/or therapeutic intervention may improve COVID-19 outcomes.
Substances chimiques
Biomarkers
0
Vitamin D
1406-16-2
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
733-740Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
Toraih EA, Elshazli RM, Hussein MH, et al. Association of cardiac biomarkers and comorbidities with increased mortality, severity, and cardiac injury in COVID-19 patients: a meta-regression and decision tree analysis. J Med Virol. 2020;92:2473-2488.
Guo YR, Cao QD, Hong ZS, et al. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak-an update on the status. Mil Med Res. 2020;7(1):11.
Wang L, Wang Y, Ye D, Liu Q. Review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence. Int J Antimicrob Ag. 2020;55:105948.
Tsatsakis A, Petrakis D, Nikolouzakis TK, et al. COVID-19, an opportunity to reevaluate the correlation between long-term effects of anthropogenic pollutants on viral epidemic/pandemic events and prevalence. Food Chem Toxicol. 2020;141:111418.
Li Q, Guan X, Wu P, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 2020;382(13):1199-1207.
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. 2020;395(10223):497-506.
Kakodkar P, Kaka N, Baig MN. A comprehensive literature review on the clinical presentation, and management of the pandemic coronavirus disease 2019 (COVID-19). Cureus. 2020;12(4):e7560.
Lau FH, Majumder R, Torabi R. Vitamin D insufficiency is prevalent in severe COVID-19. medRxiv. 2020. https://doi.org/10.1101/2020.04.24.20075838
Zhang B, Zhou X, Qiu Y. Clinical characteristics of 82 death cases with COVID-19. PLoS ONE. 2020;15(7):e0235458.
Team CC-R. Severe outcomes among patients with coronavirus disease 2019 (COVID-19)-United States, February 12-March 16, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(12):343-346.
Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc. 2010;85(8):752-758.
Rhodes JM, Subramanian S, Laird E, Griffin G, Kenny RA. Perspective: vitamin D deficiency and COVID-19 severity-plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2, and thrombosis (R1). J Intern Med. 2020. https://doi.org/10.1111/joim.13149
Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535.
Wallace BC, Dahabreh IJ, Trikalinos TA, Lau J, Trow P, Schmid CH. Closing the gap between methodologists and end-users: Ras a computational back-end. J Stat Softw. 2012;49(5):15.
Pierce CA. Software Review: Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2006). Comprehensive meta-analysis (version 2.2.027) [computer software]. Englewood, NJ: Biostat. Organizational Research Methods. 2008;11(1):188-191.
De Smet D, De Smet K, Herroelen P, Gryspeerdt S, Martens GA. Vitamin D deficiency as risk factor for severe COVID-19: a convergence of two pandemics. medRxiv. 2020. https://doi.org.10.1101/2020.05.01.20079376
Lin L, Chu H. Quantifying publication bias in meta-analysis. Biometrics. 2018;74(3):785-794.
Elshazli RM, Toraih EA, Elgaml A, Kandil E, Fawzy MS Genetic polymorphisms of TP53 (rs1042522) and MDM2 (rs2279744) and colorectal cancer risk: an updated meta-analysis based on 59 case-control studies. Gene. 2020;734:144391.
D'Avolio A, Avataneo V, Manca A., et al. 25-Hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2. Nutrients. 2020;12(5):1359.
Tian Y, Rong L. Letter: does vitamin D have a potential role against COVID-19? Authors' reply. Aliment Pharmacol Ther. 2020;52:410-411.
Faul JL, Kerley CP, Love B, et al. Vitamin D deficiency and ARDS after SARS-CoV-2 infection. Ir Med J. 2020;113(5):84.
Pinzon RT, Angela A, Pradana AW. Vitamin D deficiency among patients with COVID-19: case series and recent literature review. Research Square. 2020. https://doi.org/10.21203/rs.3.rs-29473/v1
Gombart AF. The vitamin D-antimicrobial peptide pathway and its role in protection against infection. Future Microbiol. 2009;4(9):1151-1165.
Toraih EA, Sedhom JA, Dokunmu TM. Hiddenin plain sight: the effects of BCG vaccination in COVID-19 pandemic. bioRxiv. 2020. https://doi.org/10.1101/2020.06.09.142760
Coperchini F, Chiovato L, Croce L, Magri F, Rotondi M. The cytokine storm in COVID-19: an overview of the involvement of the chemokine/chemokine-receptor system. Cytokine Growth Factor Rev. 2020;53:25-32.
Curtis N, Sparrow A, Ghebreyesus TA, Netea MG. Considering BCG vaccination to reduce the impact of COVID-19. Lancet. 2020;395(10236):1545-1546.
Grant WB, Lahore H, McDonnell SL, et al. Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients. 2020;12(4):988.
Henrina J, Lim M, Pranata R. COVID-19 and misinformation: how an infodemic fueled the prominence of vitamin D. Br J Nutr. 2020:1-6.