Ferrochelatase regulates retinal neovascularization.

Animals Cell Hypoxia Cell Proliferation / drug effects Female Ferrochelatase / antagonists & inhibitors Griseofulvin / pharmacology Mice Mice, Inbred C57BL Retina / drug effects Retinal Neovascularization / drug therapy
angiogenesis griseofulvin heme synthesis retina vasculature

Journal

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484

Informations de publication

Date de publication:
09 2020
Historique:
received: 02 06 2020
revised: 01 07 2020
accepted: 06 07 2020
pubmed: 28 7 2020
medline: 17 3 2021
entrez: 28 7 2020
Statut: ppublish

Résumé

Ferrochelatase (FECH) is the terminal enzyme in heme biosynthesis. We previously showed that FECH is required for endothelial cell growth in vitro and choroidal neovascularization in vivo. But FECH has not been explored in retinal neovascularization, which underlies diseases like proliferative diabetic retinopathy and retinopathy of prematurity. Here, we investigated the inhibition of FECH using genetic and chemical approaches in the oxygen-induced retinopathy (OIR) mouse model. In OIR mice, FECH expression is upregulated and co-localized with neovascular tufts. Partial loss-of-function Fech

Identifiants

DOI: 10.1096/fj.202000964R PMID: 32716567 PMC: PMC7726024
pubmed: 32716567
doi: 10.1096/fj.202000964R
pmc: PMC7726024
mid: NIHMS1622055
doi:

Substances chimiques

Griseofulvin 32HRV3E3D5
Ferrochelatase EC 4.99.1.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

12419-12435

Subventions

Organisme : NEI NIH HHS
ID : R01 EY025641
Pays : United States

Informations de copyright

© 2020 Federation of American Societies for Experimental Biology.

Références

J Med Chem. 2015 Jun 25;58(12):5015-5027
pubmed: 26035340
PLoS One. 2018 Jul 9;13(7):e0200307
pubmed: 29985945
J Chem Inf Model. 2016 Dec 27;56(12):2421-2433
pubmed: 27801584
Mol Vis. 2015 May 01;21:515-22
pubmed: 25999678
Asia Pac J Ophthalmol (Phila). 2018 May-Jun;7(3):145-151
pubmed: 29633587
ACS Chem Biol. 2018 Jan 19;13(1):45-52
pubmed: 29193961
Exp Eye Res. 2009 Jun;88(6):1004-13
pubmed: 19176215
Invest Ophthalmol Vis Sci. 1999 Jan;40(1):182-9
pubmed: 9888442
J Pharmacol Exp Ther. 2018 Oct;367(1):108-118
pubmed: 30076264
Invest Ophthalmol Vis Sci. 2010 Jun;51(6):2813-26
pubmed: 20484600
EMBO Mol Med. 2017 Jun;9(6):786-801
pubmed: 28377496
J Anat. 2002 Jun;200(6):629-38
pubmed: 12162730
Semin Perinatol. 2019 Oct;43(6):375-380
pubmed: 31174872
Methods Mol Biol. 2012;884:213-27
pubmed: 22688709
Cold Spring Harb Protoc. 2014 Jun 02;2014(6):655-8
pubmed: 24890205
Antioxid Redox Signal. 2003 Apr;5(2):155-62
pubmed: 12716475
Invest Ophthalmol Vis Sci. 2003 Dec;44(12):5410-6
pubmed: 14638745
iScience. 2020 Aug 21;23(8):101391
pubmed: 32755804
Vision Res. 2004;44(21):2445-56
pubmed: 15358080
J Dermatol. 2007 Nov;34(11):790-4
pubmed: 17973823
Prog Retin Eye Res. 2008 Jul;27(4):331-71
pubmed: 18653375
Sci Rep. 2016 May 05;6:25509
pubmed: 27148944
J Clin Invest. 1991 Nov;88(5):1730-6
pubmed: 1939658
Genomics. 1993 Jun;16(3):645-8
pubmed: 8325637
Sci Rep. 2017 Feb 08;7:41975
pubmed: 28176804
Chem Rev. 2014 Dec 24;114(24):12088-107
pubmed: 25476923
J Cell Physiol. 2000 Sep;184(3):301-10
pubmed: 10911360
Front Pharmacol. 2012 Jul 19;3:119
pubmed: 22833723
Annu Rev Cell Dev Biol. 2011;27:563-84
pubmed: 21756109
Nat Protoc. 2009;4(11):1565-73
pubmed: 19816419
Chem Rev. 2009 Oct;109(10):4596-616
pubmed: 19764719
J Clin Invest. 2011 May;121(5):1974-85
pubmed: 21505259
Cochrane Database Syst Rev. 2016;2:CD009734
pubmed: 26932750
Glia. 2015 Oct;63(10):1809-24
pubmed: 25943952
Adv Exp Med Biol. 2006;572:163-8
pubmed: 17249570
Front Pharmacol. 2020 Jul 15;11:1015
pubmed: 32760270
Blood. 2003 Jan 1;101(1):348-50
pubmed: 12393745
Blood. 2011 Jun 2;117(22):6024-35
pubmed: 21355092
Haematologica. 2014 Jun;99(6):973-83
pubmed: 24881043
Clin Exp Ophthalmol. 2003 Aug;31(4):300-4
pubmed: 12880453
N Engl J Med. 2012 Dec 27;367(26):2515-26
pubmed: 23268666
Exp Eye Res. 2011 Dec;93(6):921-6
pubmed: 22067127
Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1153-63
pubmed: 16910763
Cell Mol Biol (Noisy-le-grand). 2009 Jul 01;55(2):127-39
pubmed: 19656461
Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4281-7
pubmed: 16249509
Orphanet J Rare Dis. 2009 Sep 10;4:19
pubmed: 19744342
Cell Metab. 2018 Oct 2;28(4):573-587.e13
pubmed: 30017355
Invest Ophthalmol Vis Sci. 1994 Jan;35(1):101-11
pubmed: 7507904
Life Sci. 2004 Sep 10;75(17):2035-43
pubmed: 15312748
Front Pharmacol. 2014 Apr 08;5:61
pubmed: 24782769
Front Biosci. 2003 May 01;8:d1030-43
pubmed: 12700061
Eye Brain. 2016;8:67-79
pubmed: 27499653
Biochem Pharmacol. 2015 Dec 1;98(3):493-501
pubmed: 26343413
Prog Retin Eye Res. 2015 Nov;49:67-81
pubmed: 26113211
Vision Res. 2004;44(16):1857-67
pubmed: 15145680
J Clin Invest. 2010 Sep;120(9):3022-32
pubmed: 20811158
Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H738-49
pubmed: 27473938
J AAPOS. 2016 Dec;20(6):539-540.e3
pubmed: 27810419
Biochim Biophys Acta. 2012 Sep;1823(9):1617-32
pubmed: 22575458
Sci Rep. 2017 Aug 25;7(1):9517
pubmed: 28842607
Ophthalmology. 2017 May;124(5):619-633
pubmed: 28341474
N Engl J Med. 2005 Aug 25;353(8):839-41
pubmed: 16120866
Blood. 2004 Feb 1;103(3):761-6
pubmed: 14525760
Nature. 1992 Oct 29;359(6398):843-5
pubmed: 1279431
Nature. 2005 Dec 15;438(7070):960-6
pubmed: 16355161
PLoS One. 2011;6(7):e22244
pubmed: 21779402
Transl Vis Sci Technol. 2016 Mar 11;5(2):10
pubmed: 26981332
Nat Med. 2009 May;15(5):553-8
pubmed: 19377486
Biochem J. 2006 Oct 1;399(1):21-8
pubmed: 16792525
Org Biomol Chem. 2014 Oct 21;12(39):7673-7
pubmed: 25167470

Auteurs

Sardar Pasha Sheik Pran Babu (SPS)

Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.

Darcy White (D)

Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.

Timothy W Corson (TW)

Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Ferrochelatase regulates retinal neovascularization.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Respiration cellulaire › Hypoxie cellulaire › Ferrochelatase regulates retinal neovascularization.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Ferrochelatase regulates retinal neovascularization.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Ferrochelatase › Ferrochelatase regulates retinal neovascularization.
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzofuranes › Griséofulvine › Ferrochelatase regulates retinal neovascularization.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Ferrochelatase regulates retinal neovascularization.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Ferrochelatase regulates retinal neovascularization.
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Ferrochelatase regulates retinal neovascularization.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Métaplasie › Néovascularisation pathologique › Néovascularisation rétinienne › Ferrochelatase regulates retinal neovascularization.