Genomics approaches to synthesize plant-based biomolecules for therapeutic applications to combat SARS-CoV-2.
Coronavirus
Genetic manipulation
Genomics
Plant-based drugs
SARS-CoV-2
Therapeutics
Journal
Genomics
ISSN: 1089-8646
Titre abrégé: Genomics
Pays: United States
ID NLM: 8800135
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
01
07
2020
revised:
10
07
2020
accepted:
20
07
2020
pubmed:
28
7
2020
medline:
1
1
2021
entrez:
28
7
2020
Statut:
ppublish
Résumé
COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is devastative to the humankind for which neither vaccines nor precise therapeutic molecules for treatment are identified. The search for new drugs and repurposing of existing drugs are being performed; however, at the same time, research on plants to identify novel therapeutic compounds or testing the existing ones is progressing at a slower phase. In this context, genomics and biotechnology offer various tools and strategies to manipulate plants for producing those complex biopharmaceutical products. This review enumerates the scope for research on plant-based molecules for their potential application in treating SARS-CoV-2 infection. Strategies to edit gene and genome, overexpression and silencing approaches, and molecular breeding for producing target biomolecules in the plant system are discussed in detail. Altogether, the present review provides a roadmap for expediting research on using plants as a novel source of active biomolecules having therapeutic applications.
Identifiants
pubmed: 32717321
pii: S0888-7543(20)30895-8
doi: 10.1016/j.ygeno.2020.07.033
pmc: PMC7381398
pii:
doi:
Substances chimiques
Antiviral Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4322-4331Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Références
N Engl J Med. 2020 May 21;382(21):1969-1973
pubmed: 32227757
Sci Total Environ. 2020 Jul 10;725:138277
pubmed: 32278175
Behav Brain Res. 2019 Feb 1;359:771-782
pubmed: 30114434
Saudi J Biol Sci. 2019 Mar;26(3):554-562
pubmed: 30899171
J Biomol Struct Dyn. 2020 Jun 1;:1-13
pubmed: 32431217
Int Immunopharmacol. 2015 Apr;25(2):302-10
pubmed: 25698556
Cell Physiol Biochem. 2015;37(6):2425-33
pubmed: 26646898
Brain Res. 1989 Feb 13;479(2):306-12
pubmed: 2647210
Int J Biol Sci. 2020 Mar 15;16(10):1708-1717
pubmed: 32226288
Antiviral Res. 2020 Jun;178:104786
pubmed: 32251767
Sci Total Environ. 2020 Aug 1;728:138859
pubmed: 32334163
Nutr Metab (Lond). 2015 Jun 05;12:20
pubmed: 26064179
Toxicol Appl Pharmacol. 2011 Jul 1;254(1):56-64
pubmed: 21515303
Asian Pac J Trop Med. 2011 Nov;4(11):866-9
pubmed: 22078948
Cell Immunol. 2017 Dec;322:64-73
pubmed: 29066080
Bioorg Med Chem. 2018 Jan 1;26(1):278-284
pubmed: 29224994
Phytomedicine. 2015 Nov 15;22(12):1088-95
pubmed: 26547531
Front Plant Sci. 2020 Mar 03;11:33
pubmed: 32194578
Planta Med. 1996 Apr;62(2):137-40
pubmed: 8657746
J Nat Prod. 2014 Feb 28;77(2):311-9
pubmed: 24456556
J Biomol Struct Dyn. 2020 May 12;:1-12
pubmed: 32340562
Planta Med. 1998 Jun;64(5):400-3
pubmed: 9690339
J Tradit Complement Med. 2011 Oct;1(1):41-50
pubmed: 24716104
Neurosci Lett. 2002 Apr 12;322(3):145-8
pubmed: 11897159
J Ethnopharmacol. 2015 Apr 22;164:328-33
pubmed: 25701752
Cell Res. 2020 Mar;30(3):269-271
pubmed: 32020029
J Genet. 2020;99:
pubmed: 32482926
Inflammation. 2014 Oct;37(5):1476-85
pubmed: 24706026
Nat Prod Commun. 2009 Nov;4(11):1575-6
pubmed: 19967994
Eur J Pain. 2017 Jul;21(6):1039-1050
pubmed: 28158929
Thromb Res. 2003 Jun 15;110(5-6):255-8
pubmed: 14592543
Planta Med. 1995 Apr;61(2):113-5
pubmed: 7753915
J Integr Med. 2018 Jan;16(1):62-70
pubmed: 29397096
J Biomol Struct Dyn. 2020 May 6;:1-9
pubmed: 32306860
Sci Rep. 2016 Sep 06;6:32756
pubmed: 27595800
Neurochem Res. 2015 Sep;40(9):1792-8
pubmed: 26152332
J Enzyme Inhib Med Chem. 2017 Dec;32(1):504-515
pubmed: 28112000
J Virol. 2004 Oct;78(20):11334-9
pubmed: 15452254
Biochim Biophys Acta. 2013 Dec;1833(12):2866-2878
pubmed: 23872422
Chin J Nat Med. 2015 May;13(5):368-74
pubmed: 25986286
Food Chem Toxicol. 2012 Nov;50(11):4042-50
pubmed: 22943973
Pediatr Infect Dis J. 2014 May;33(5):522-4
pubmed: 24736442
Pharmazie. 2003 Jan;58(1):53-7
pubmed: 12622254
World J Gastroenterol. 2006 Sep 21;12(35):5721-5
pubmed: 17007029
Plant Cell Rep. 2020 Sep;39(9):1109-1114
pubmed: 32561979
Fitoterapia. 2011 Dec;82(8):1290-4
pubmed: 21958967
Bioorg Med Chem. 2012 Oct 1;20(19):5928-35
pubmed: 22884354
Plants (Basel). 2020 Feb 04;9(2):
pubmed: 32033134
World J Gastroenterol. 2004 Dec 1;10(23):3500-5
pubmed: 15526373
Antiviral Res. 2016 Sep;133:1-8
pubmed: 27424494
J Biomol Struct Dyn. 2020 Apr 13;:1-10
pubmed: 32238094
Food Chem Toxicol. 2013 Dec;62:506-13
pubmed: 24051194
Bioorg Med Chem. 2010 Nov 15;18(22):7940-7
pubmed: 20934345
Cell Discov. 2020 Mar 16;6:14
pubmed: 32194980
Allergy. 2012 May;67(5):676-82
pubmed: 22435735
J Biomol Struct Dyn. 2020 Jul 22;:1-11
pubmed: 32696720
J Virol. 2019 May 29;93(12):
pubmed: 30918074
Ethiop Med J. 2005 Jan;43(1):15-20
pubmed: 16370525
Evid Based Complement Alternat Med. 2005 Jun;2(2):209-215
pubmed: 15937562
Antiviral Res. 2018 Apr;152:104-110
pubmed: 29458133
Antiviral Res. 2009 Apr;82(1):73-81
pubmed: 19428598
BMC Complement Altern Med. 2017 Jan 18;17(1):54
pubmed: 28100216
Food Chem Toxicol. 2017 Jan;99:162-169
pubmed: 27908701
Phytother Res. 2005 Apr;19(4):355-8
pubmed: 16041735
Bioorg Med Chem Lett. 2010 Mar 15;20(6):1873-6
pubmed: 20167482
Plants (Basel). 2019 Dec 24;9(1):
pubmed: 31878277
Arch Pharm Res. 2014;37(9):1201-10
pubmed: 24424605
Antiviral Res. 2009 Jan;81(1):77-81
pubmed: 18992773
J Ethnopharmacol. 2012 Jan 6;139(1):189-93
pubmed: 22101082
BMC Complement Altern Med. 2014 Nov 18;14:448
pubmed: 25407486
J Enzyme Inhib Med Chem. 2020 Dec;35(1):145-151
pubmed: 31724441
Cochrane Database Syst Rev. 2012 Oct 17;10:CD004882
pubmed: 23076910
Pharm Biol. 2020 Dec;58(1):257-264
pubmed: 32208946
J Biomol Struct Dyn. 2020 Apr 15;:1-11
pubmed: 32238078
Evid Based Complement Alternat Med. 2011;2011:253643
pubmed: 20008902
Cell Biol Int. 2020 Sep;44(9):1870-1880
pubmed: 32437058
Trends Plant Sci. 2020 Jul;25(7):635-643
pubmed: 32371057
Pharmacology. 1995 Dec;51(6):356-63
pubmed: 8966192
Microbiologica. 1988 Jan;11(1):55-61
pubmed: 2832710
J Gen Microbiol. 1952 Feb;6(1-2):74-84
pubmed: 14927853
Bioorg Med Chem. 2013 Jun 1;21(11):3051-7
pubmed: 23623680
J Biomol Struct Dyn. 2020 May 5;:1-10
pubmed: 32340551
Phytother Res. 2016 Jan;30(1):144-51
pubmed: 26549702
Proc Natl Acad Sci U S A. 1988 Feb;85(4):1267-71
pubmed: 3422490
Inflammation. 2017 Jun;40(3):1051-1061
pubmed: 28332176
Cancer Lett. 2013 Dec 1;341(2):139-49
pubmed: 23962559
Pharm Biol. 2016 Jul;54(7):1117-24
pubmed: 26439905
J Chem Inf Model. 2020 Jun 22;60(6):3277-3286
pubmed: 32315171
Microorganisms. 2020 Jan 08;8(1):
pubmed: 31936284
Fitoterapia. 2013 Sep;89:68-73
pubmed: 23685048
J Med Virol. 2020 Jun;92(6):693-697
pubmed: 32167173
Cytokine. 2017 Mar;91:57-64
pubmed: 28011397
Pharm Methods. 2011 Jan;2(1):3-8
pubmed: 23781422
Antiviral Res. 2011 Apr;90(1):22-32
pubmed: 21338626
Biomolecules. 2019 Nov 04;9(11):
pubmed: 31690059
Biomed Rep. 2016 Dec;5(6):715-722
pubmed: 28101344
Iran J Allergy Asthma Immunol. 2019 Jun 08;18(3):320-331
pubmed: 31522439
J Med Chem. 2005 Feb 24;48(4):1256-9
pubmed: 15715493
J Med Chem. 2004 Feb 26;47(5):1079-80
pubmed: 14971887
Food Funct. 2014 Sep;5(9):2106-12
pubmed: 24998475
ACS Omega. 2020 Mar 31;5(14):8312-8320
pubmed: 32363255
J Tradit Chin Med. 2004 Dec;24(4):266-9
pubmed: 15688692
Ann N Y Acad Sci. 2005 Nov;1056:293-302
pubmed: 16387696
Antiviral Res. 2005 Oct;68(1):36-42
pubmed: 16115693
ACS Omega. 2019 Aug 21;4(10):14188-14192
pubmed: 31508540