HPV-positive HNSCC cell lines show strongly enhanced radiosensitivity after photon but not after carbon ion irradiation.
Carbon ion irradiation
Double-strand breaks
HNSCC
HPV negative
HPV positive
Radiosensitivity
Journal
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
ISSN: 1879-0887
Titre abrégé: Radiother Oncol
Pays: Ireland
ID NLM: 8407192
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
23
04
2020
revised:
29
06
2020
accepted:
20
07
2020
pubmed:
28
7
2020
medline:
15
4
2021
entrez:
28
7
2020
Statut:
ppublish
Résumé
HPV positive (pos.) HNSCC cells are significantly more radiosensitive to photon irradiation as compared to HPV negative (neg.) cells. Functionally, this is considered to result from a reduced DSB repair capacity. It was now tested, whether such a difference is also observed when using carbon ion ( Five HPV pos. and five HPV neg. HNSCC cell lines were irradiated with photons or The pronounced difference in radiosensitivity known for these two entities when exposed to photons in 2D cell culture, was reduced when treated under 3D conditions. Irradiation with While HPV pos. cells are significantly more radiosensitive to photons than HPV neg. cells, no significant difference was seen after
Sections du résumé
BACKGROUND AND PURPOSE
HPV positive (pos.) HNSCC cells are significantly more radiosensitive to photon irradiation as compared to HPV negative (neg.) cells. Functionally, this is considered to result from a reduced DSB repair capacity. It was now tested, whether such a difference is also observed when using carbon ion (
MATERIAL AND METHODS
Five HPV pos. and five HPV neg. HNSCC cell lines were irradiated with photons or
RESULTS
The pronounced difference in radiosensitivity known for these two entities when exposed to photons in 2D cell culture, was reduced when treated under 3D conditions. Irradiation with
CONCLUSION
While HPV pos. cells are significantly more radiosensitive to photons than HPV neg. cells, no significant difference was seen after
Identifiants
pubmed: 32717362
pii: S0167-8140(20)30677-0
doi: 10.1016/j.radonc.2020.07.032
pii:
doi:
Substances chimiques
Carbon
7440-44-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
134-140Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.