Interleukin-6 in Rheumatoid Arthritis.
IL-6
inflammation
rheumatoid arthritis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 07 2020
23 07 2020
Historique:
received:
02
07
2020
revised:
18
07
2020
accepted:
20
07
2020
entrez:
29
7
2020
pubmed:
29
7
2020
medline:
13
8
2020
Statut:
epublish
Résumé
The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in which IL-6 is involved are also partly responsible of the development and progression of rheumatoid arthritis (RA), opening interesting perspectives in terms of therapy. Anti-IL-6 drugs are being used with variable degrees of success in other diseases and are being tested in RA. Results have been encouraging, particularly when anti-IL-6 has been used with other drugs, such as metothrexate (MTX). In this review we discuss the main immunologic aspects that make anti-IL-6 a good candidate in RA, but despite the main therapeutic options available to target IL-6, no gold standard treatment has been established so far.
Identifiants
pubmed: 32718086
pii: ijms21155238
doi: 10.3390/ijms21155238
pmc: PMC7432115
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
IL6 protein, human
0
Interleukin-6
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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