siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice.

Animals Apoptosis Calcium-Calmodulin-Dependent Protein Kinase Type 2 Macrophages Mice Mice, Knockout Nanoparticles Plaque, Atherosclerotic RNA, Small Interfering

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
22 07 2020
Historique:
received: 20 05 2019
revised: 26 02 2020
accepted: 15 06 2020
entrez: 29 7 2020
pubmed: 29 7 2020
medline: 24 6 2021
Statut: ppublish

Résumé

Atherosclerotic lesional macrophages express molecules that promote plaque progression, but lack of mechanisms to therapeutically target these molecules represents a major gap in translational cardiovascular research. Here, we tested the efficacy of a small interfering RNA (siRNA) nanoparticle (NP) platform targeting a plaque-destabilizing macrophage molecule-Ca

Identifiants

DOI: 10.1126/scitranslmed.aay1063 PMID: 32718990 PMC: PMC7476570
pubmed: 32718990
pii: 12/553/eaay1063
doi: 10.1126/scitranslmed.aay1063
pmc: PMC7476570
mid: NIHMS1624894
pii:
doi:

Substances chimiques

RNA, Small Interfering 0
Calcium-Calmodulin-Dependent Protein Kinase Type 2 EC 2.7.11.17

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NHLBI NIH HHS
ID : R35 HL145228
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL145131
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132412
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL127464
Pays : United States
Organisme : NHLBI NIH HHS
ID : K99 HL145131
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL087123
Pays : United States

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Auteurs

Wei Tao (W)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0002-4277-3728

Arif Yurdagul (A)

Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
ORCID: 0000-0002-7613-6313

Na Kong (N)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0002-3823-8335

Wenliang Li (W)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Xiaobo Wang (X)

Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.

Amanda C Doran (AC)

Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
ORCID: 0000-0002-1576-6274

Chan Feng (C)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Junqing Wang (J)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0002-9091-9891

Mohammad Ariful Islam (MA)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0002-7242-0026

Omid C Farokhzad (OC)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. ofarokhzad@bwh.harvard.edu iat1@columbia.edu jshi@bwh.harvard.edu.
ORCID: 0000-0003-2009-270X

Ira Tabas (I)

Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA. ofarokhzad@bwh.harvard.edu iat1@columbia.edu jshi@bwh.harvard.edu.
Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
ORCID: 0000-0003-3429-1515

Jinjun Shi (J)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. ofarokhzad@bwh.harvard.edu iat1@columbia.edu jshi@bwh.harvard.edu.
ORCID: 0000-0001-9200-5068

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › siRNA nanoparticles targeting CaMKIIγ in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › siRNA nanoparticles targeting CaMKIIγ in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Calcium-Calmodulin-Dependent Protein Kinases › Calcium-Calmodulin-Dependent Protein Kinase Type 2 › siRNA nanoparticles targeting CaMKIIγ in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › siRNA nanoparticles targeting CaMKIIγ in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › siRNA nanoparticles targeting CaMKIIγ in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › siRNA nanoparticles targeting CaMKIIγ in...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › siRNA nanoparticles targeting CaMKIIγ in...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Plaque d'athérosclérose › siRNA nanoparticles targeting CaMKIIγ in...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › siRNA nanoparticles targeting CaMKIIγ in...