Magnesium sulfate prophylaxis attenuates the postpartum effects of preeclampsia by promoting M2 macrophage polarization.

Animals Female Macrophages Magnesium Sulfate / pharmacology Postpartum Period Pre-Eclampsia / drug therapy Pregnancy Rats Rats, Sprague-Dawley
Inflammatory cytokine Kidney injury Macrophage polarization Magnesium sulfate Postpartum preeclampsia

Journal

Hypertension research : official journal of the Japanese Society of Hypertension
ISSN: 1348-4214
Titre abrégé: Hypertens Res
Pays: England
ID NLM: 9307690

Informations de publication

Date de publication:
Jan 2021
Historique:
received: 29 02 2020
accepted: 18 06 2020
revised: 13 06 2020
pubmed: 29 7 2020
medline: 15 12 2021
entrez: 29 7 2020
Statut: ppublish

Résumé

Preeclampsia is a complex disorder that is characterized by new onset hypertension and proteinuria at or after 20 weeks of gestation. Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. MgSO

Identifiants

DOI: 10.1038/s41440-020-0511-4 PMID: 32719464
pubmed: 32719464
doi: 10.1038/s41440-020-0511-4
pii: 10.1038/s41440-020-0511-4
doi:

Substances chimiques

Magnesium Sulfate 7487-88-9

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

13-22

Références

Tranquilli AL, Dekker G, Magee L, Roberts J, Sibai BM, Steyn W, et al. The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP. Pregnancy Hypertens. 2014;4:97–104. https://doi.org/10.1016/j.preghy.2014.02.001 .
doi: 10.1016/j.preghy.2014.02.001 pubmed: 26104417
Black KD, Horowitz JA. Inflammatory markers and preeclampsia: a systematic review. Nurs Res. 2018;67:242–51. https://doi.org/10.1097/NNR.0000000000000285 .
doi: 10.1097/NNR.0000000000000285 pubmed: 29698330
Tang J, He A, Li N, Chen X, Zhou X, Fan X, et al. Magnesium sulfate-mediated vascular relaxation and calcium channel activity in placental vessels different from nonplacental vessels. J Am Heart Assoc. 2018;7. https://doi.org/10.1161/JAHA.118.009896 .
Clayton AM, Shao Q, Paauw ND, Giambrone AB, Granger JP, Warrington JP. Postpartum increases in cerebral edema and inflammation in response to placental ischemia during pregnancy. Brain Behav Immun. 2018;70:376–89. https://doi.org/10.1016/j.bbi.2018.03.028 .
doi: 10.1016/j.bbi.2018.03.028 pubmed: 29588233 pmcid: 5953832
Conrad KP, Miles TM, Benyo DF. Circulating levels of immunoreactive cytokines in women with preeclampsia. Am J Reprod Immunol. 1998;40:102–11. https://doi.org/10.1111/j.1600-0897.1998.tb00398.x .
doi: 10.1111/j.1600-0897.1998.tb00398.x pubmed: 9764352
Kara AE, Guney G, Tokmak A, Ozaksit G. The role of inflammatory markers hs-CRP, sialic acid, and IL-6 in the pathogenesis of preeclampsia and intrauterine growth restriction. Eur Cytokine Netw. 2019;30:29–33. https://doi.org/10.1684/ecn.2019.0423 .
doi: 10.1684/ecn.2019.0423 pubmed: 31074415
Kim S, Lee KS, Choi S, Kim J, Lee DK, Park M, et al. NF-kappaB-responsive miRNA-31-5p elicits endothelial dysfunction associated with preeclampsia via down-regulation of endothelial nitric-oxide synthase. J Biol Chem. 2018;293:18989–9000. https://doi.org/10.1074/jbc.RA118.005197 .
doi: 10.1074/jbc.RA118.005197 pubmed: 30279269 pmcid: 6295733
Li X, Han X, Bao J, Liu Y, Ye A, Thakur M, et al. Nicotine increases eclampsia-like seizure threshold and attenuates microglial activity in rat hippocampus through the alpha7 nicotinic acetylcholine receptor. Brain Res. 2016;1642:487–96. https://doi.org/10.1016/j.brainres.2016.04.043 .
doi: 10.1016/j.brainres.2016.04.043 pubmed: 27106269
Li X, Han X, Yang J, Bao J, Di X, Zhang G, et al. Magnesium sulfate provides neuroprotection in eclampsia-like seizure model by ameliorating neuroinflammation and brain edema. Mol Neurobiol. 2017;54:7938–48. https://doi.org/10.1007/s12035-016-0278-4 .
doi: 10.1007/s12035-016-0278-4 pubmed: 27878553
Sibai BM. Magnesium sulfate is the ideal anticonvulsant in preeclampsia-eclampsia. Am J Obstet Gynecol. 1990;162:1141–5. https://doi.org/10.1016/0002-9378(90)90002-o .
doi: 10.1016/0002-9378(90)90002-o pubmed: 2288560
Celik Kavak E, Gulcu Bulmus F, Bulmus O, Kavak SB, Kocaman N. Magnesium: does it reduce ischemia/reperfusion injury in an adnexal torsion rat model?. Drug Des Dev Ther. 2018;12:409–15. https://doi.org/10.2147/DDDT.S157115 .
doi: 10.2147/DDDT.S157115
Li X, Liu H, Yang Y. Magnesium sulfate attenuates brain edema by lowering AQP4 expression and inhibits glia-mediated neuroinflammation in a rodent model of eclampsia. Behav Brain Res. 2019;364:403–12. https://doi.org/10.1016/j.bbr.2017.12.031 .
doi: 10.1016/j.bbr.2017.12.031 pubmed: 29288747
Zhang YH, He M, Wang Y, Liao AH. Modulators of the balance between M1 and M2 macrophages during pregnancy. Front Immunol. 2017;8:120. https://doi.org/10.3389/fimmu.2017.00120 .
doi: 10.3389/fimmu.2017.00120 pubmed: 28232836 pmcid: 5299000
Schonkeren D, van der Hoorn ML, Khedoe P, Swings G, van Beelen E, Claas F, et al. Differential distribution and phenotype of decidual macrophages in preeclamptic versus control pregnancies. Am J Pathol. 2011;178:709–17. https://doi.org/10.1016/j.ajpath.2010.10.011 .
doi: 10.1016/j.ajpath.2010.10.011 pubmed: 21281803 pmcid: 3069820
Faas MM, Schuiling GA, Baller JF, Visscher CA, Bakker WW. A new animal model for human preeclampsia: ultra-low-dose endotoxin infusion in pregnant rats. Am J Obstet Gynecol. 1994;171:158–64. https://doi.org/10.1016/0002-9378(94)90463-4 .
doi: 10.1016/0002-9378(94)90463-4 pubmed: 8030692
Orhan N, Ugur Yilmaz C, Ekizoglu O, Ahishali B, Arican N, Kucuk M, et al. The effects of superoxide dismutase mimetic MnTMPyP on the altered blood-brain barrier integrity in experimental preeclampsia with or without seizures in rats. Brain Res. 2014;1563:91–102. https://doi.org/10.1016/j.brainres.2014.03.029 .
doi: 10.1016/j.brainres.2014.03.029 pubmed: 24680906
Wu WM, Suen JL, Lin BF, Chiang BL. Tamoxifen alleviates disease severity and decreases double negative T cells in autoimmune MRL-lpr/lpr mice. Immunology. 2000;100:110–8. https://doi.org/10.1046/j.1365-2567.2000.00998.x .
doi: 10.1046/j.1365-2567.2000.00998.x pubmed: 10809966 pmcid: 2326982
He J, Yuan G, Cheng F, Zhang J, Guo X. Mast Cell and M1 macrophage infiltration and local pro-inflammatory factors were attenuated with incretin-based therapies in obesity-related glomerulopathy. Metab Syndr Relat Disord. 2017;15:344–53. https://doi.org/10.1089/met.2017.0057 .
doi: 10.1089/met.2017.0057 pubmed: 28737448 pmcid: 5576269
Li Z, Zhang Y, Ying Ma J, Kapoun AM, Shao Q, Kerr I, et al. Recombinant vascular endothelial growth factor 121 attenuates hypertension and improves kidney damage in a rat model of preeclampsia. Hypertension. 2007;50:686–92. https://doi.org/10.1161/HYPERTENSIONAHA.107.092098 .
doi: 10.1161/HYPERTENSIONAHA.107.092098 pubmed: 17724276
Lee CH, Wen ZH, Chang YC, Huang SY, Tang CC, Chen WF, et al. Intra-articular magnesium sulfate (MgSO4) reduces experimental osteoarthritis and nociception: association with attenuation of N-methyl-D-aspartate (NMDA) receptor subunit 1 phosphorylation and apoptosis in rat chondrocytes. Osteoarthr Cartil. 2009;17:1485–93. https://doi.org/10.1016/j.joca.2009.05.006 .
doi: 10.1016/j.joca.2009.05.006
Gao F, Ding B, Zhou L, Gao X, Guo H, Xu H. Magnesium sulfate provides neuroprotection in lipopolysaccharide-activated primary microglia by inhibiting NF-kappaB pathway. J Surg Res. 2013;184:944–50. https://doi.org/10.1016/j.jss.2013.03.034 .
doi: 10.1016/j.jss.2013.03.034 pubmed: 23628437
American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 134: fetal growth restriction. Obstet Gynecol.2013;121:1122–33. https://doi.org/10.1097/01.AOG.0000429658.85846.f9 .
doi: 10.1097/01.AOG.0000429658.85846.f9
Perucci LO, Correa MD, Dusse LM, Gomes KB, Sousa LP. Resolution of inflammation pathways in preeclampsia-a narrative review. Immunol Res. 2017;65:774–89. https://doi.org/10.1007/s12026-017-8921-3 .
doi: 10.1007/s12026-017-8921-3 pubmed: 28391374
Shaw J, Tang Z, Schneider H, Salje K, Hansson SR, Guller S. Inflammatory processes are specifically enhanced in endothelial cells by placental-derived TNF-alpha: Implications in preeclampsia (PE). Placenta. 2016;43:1–8. https://doi.org/10.1016/j.placenta.2016.04.015 .
doi: 10.1016/j.placenta.2016.04.015 pubmed: 27324092
Strevens H, Wide-Swensson D, Hansen A, Horn T, Ingemarsson I, Larsen S, et al. Glomerular endotheliosis in normal pregnancy and pre-eclampsia. BJOG. 2003;110:831–6.
doi: 10.1111/j.1471-0528.2003.02162.x
McKinney D, Boyd H, Langager A, Oswald M, Pfister A, Warshak CR. The impact of fetal growth restriction on latency in the setting of expectant management of preeclampsia. Am J Obstet Gynecol. 2016;214:395 e1–7. https://doi.org/10.1016/j.ajog.2015.12.050 .
doi: 10.1016/j.ajog.2015.12.050
Schiessl B. Inflammatory response in preeclampsia. Mol Asp Med. 2007;28:210–9. https://doi.org/10.1016/j.mam.2007.04.004 .
doi: 10.1016/j.mam.2007.04.004
Kemp PA, Gardiner SM, March JE, Rubin PC, Bennett T. Assessment of the effects of endothelin-1 and magnesium sulphate on regional blood flows in conscious rats, by the coloured microsphere reference technique. Br J Pharmacol. 1999;126:621–6. https://doi.org/10.1038/sj.bjp.0702342 .
doi: 10.1038/sj.bjp.0702342 pubmed: 10188972 pmcid: 1565849
Vishnyakova P, Elchaninov A, Fatkhudinov T, Sukhikh G. Role of the monocyte-macrophage system in normal pregnancy and preeclampsia. Int J Mol Sci. 2019;20. https://doi.org/10.3390/ijms20153695 .
Mol BWJ, Roberts CT, Thangaratinam S, Magee LA, de Groot CJM, Hofmeyr GJ. Pre-eclampsia. Lancet. 2016;387:999–1011. https://doi.org/10.1016/S0140-6736(15)00070-7 .
doi: 10.1016/S0140-6736(15)00070-7 pubmed: 26342729
Boyle AK, Rinaldi SF, Norman JE, Stock SJ. Preterm birth: Inflammation, fetal injury and treatment strategies. J Reprod Immunol. 2017;119:62–6. https://doi.org/10.1016/j.jri.2016.11.008 .
doi: 10.1016/j.jri.2016.11.008 pubmed: 28122664
Schutten JC, Joris PJ, Mensink RP, Danel RM, Goorman F, Heiner-Fokkema MR, et al. Effects of magnesium citrate, magnesium oxide and magnesium sulfate supplementation on arterial stiffness in healthy overweight individuals: a study protocol for a randomized controlled trial. Trials. 2019;20:295. https://doi.org/10.1186/s13063-019-3414-4 .
doi: 10.1186/s13063-019-3414-4 pubmed: 31138315 pmcid: 6540466
Huang Q, Liu L, Hu B, Di X, Brennecke SP, Liu H. Decreased seizure threshold in an eclampsia-like model induced in pregnant rats with lipopolysaccharide and pentylenetetrazol treatments. PLoS ONE 2014;9:e89333. https://doi.org/10.1371/journal.pone.0089333 .
doi: 10.1371/journal.pone.0089333 pubmed: 24586695 pmcid: 3930732
Yang H, Kim TH, Lee GS, Hong EJ, Jeung EB. Comparing the expression patterns of placental magnesium/phosphorus-transporting channels between healthy and preeclamptic pregnancies. Mol Reprod Dev. 2014;81:851–60. https://doi.org/10.1002/mrd.22353 .
doi: 10.1002/mrd.22353 pubmed: 25155868
Vigil-De Gracia P, Ramirez R, Duran Y, Quintero A. Magnesium sulfate for 6 vs 24 h post delivery in patients who received magnesium sulfate for less than 8 h before birth: a randomized clinical trial. BMC Pregnancy Childbirth. 2017;17:241. https://doi.org/10.1186/s12884-017-1424-3 .
doi: 10.1186/s12884-017-1424-3 pubmed: 28738788 pmcid: 5525206
Sugimoto J, Romani AM, Valentin-Torres AM, Luciano AA, Ramirez Kitchen CM, Funderburg N, et al. Magnesium decreases inflammatory cytokine production: a novel innate immunomodulatory mechanism. J Immunol. 2012;188:6338–46. https://doi.org/10.4049/jimmunol.1101765 .
doi: 10.4049/jimmunol.1101765 pubmed: 22611240
Burwick RM, Togioka BM, Speranza RJ, Gaffney JE, Roberts VHJ, Frias AE, et al. Assessment of blood-brain barrier integrity and neuroinflammation in preeclampsia. Am J Obstet Gynecol. 2019;221:269. e1–8. https://doi.org/10.1016/j.ajog.2019.06.024 .
doi: 10.1016/j.ajog.2019.06.024
de Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiol Rev. 2015;95:1–46. https://doi.org/10.1152/physrev.00012.2014 .
doi: 10.1152/physrev.00012.2014 pubmed: 25540137
Kreepala C, Luangphiphat W, Villarroel A, Kitporntheranunt M, Wattanavaekin K, Piyajarawong T. Effect of magnesium on glomerular filtration rate and recovery of hypertension in women with severe preeclampsia. Nephron. 2018;138:35–41. https://doi.org/10.1159/000481463 .
doi: 10.1159/000481463 pubmed: 29176311
Suzuki-Kakisaka H, Sugimoto J, Tetarbe M, Romani AM, Ramirez Kitchen CM, Bernstein HB. Magnesium sulfate increases intracellular magnesium reducing inflammatory cytokine release in neonates. Am J Reprod Immunol. 2013;70:213–20. https://doi.org/10.1111/aji.12118 .
doi: 10.1111/aji.12118 pubmed: 23590581
Rochelson B, Dowling O, Schwartz N, Metz CN. Magnesium sulfate suppresses inflammatory responses by human umbilical vein endothelial cells (HuVECs) through the NFkappaB pathway. J Reprod Immunol. 2007;73:101–7. https://doi.org/10.1016/j.jri.2006.06.004 .
doi: 10.1016/j.jri.2006.06.004 pubmed: 16952401
Bosio PM, McKenna PJ, Conroy R, O’Herlihy C. Maternal central hemodynamics in hypertensive disorders of pregnancy. Obstet Gynecol. 1999;94:978–84. https://doi.org/10.1016/s0029-7844(99)00430-5 .
doi: 10.1016/s0029-7844(99)00430-5 pubmed: 10576186
Paauw ND, Joles JA, Spradley FT, Bakrania B, Zsengeller ZK, Franx A, et al. Exposure to placental ischemia impairs postpartum maternal renal and cardiac function in rats. Am J Physiol Regul Integr Comp Physiol. 2017;312:R664–70. https://doi.org/10.1152/ajpregu.00510.2016 .
doi: 10.1152/ajpregu.00510.2016 pubmed: 28202440 pmcid: 5451567
Tomimatsu T, Mimura K, Endo M, Kumasawa K, Kimura T. Pathophysiology of preeclampsia: an angiogenic imbalance and long-lasting systemic vascular dysfunction. Hypertens Res. 2017;40:305–10. https://doi.org/10.1038/hr.2016.152 .
doi: 10.1038/hr.2016.152 pubmed: 27829661

Auteurs

Xiaolan Li (X)

Department of Obstetrics and Gynecology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
NHC Key Laboratory of the Study of Abnormal Gametes and the Reproductive Tract, Anhui Medical University, Hefei, China.
Key Laboratory of Population Health Across the Life Cycle, Anhui Medical University, Ministry of Education, the People's Republic of China, Hefei, China.
Anhui Province Key Laboratory of Reproductive Health and Genetics, Biopreservation and Artificial Organs, Hefei, China.
Anhui Provincial Engineering Research Center, Anhui Medical University, Hefei, China.

Li Li (L)

Department of Obstetrics and Gynecology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
NHC Key Laboratory of the Study of Abnormal Gametes and the Reproductive Tract, Anhui Medical University, Hefei, China.
Key Laboratory of Population Health Across the Life Cycle, Anhui Medical University, Ministry of Education, the People's Republic of China, Hefei, China.
Anhui Province Key Laboratory of Reproductive Health and Genetics, Biopreservation and Artificial Organs, Hefei, China.
Anhui Provincial Engineering Research Center, Anhui Medical University, Hefei, China.

Li Tao (L)

Department of Obstetrics and Gynecology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
NHC Key Laboratory of the Study of Abnormal Gametes and the Reproductive Tract, Anhui Medical University, Hefei, China.
Key Laboratory of Population Health Across the Life Cycle, Anhui Medical University, Ministry of Education, the People's Republic of China, Hefei, China.
Anhui Province Key Laboratory of Reproductive Health and Genetics, Biopreservation and Artificial Organs, Hefei, China.
Anhui Provincial Engineering Research Center, Anhui Medical University, Hefei, China.

Honghui Zheng (H)

NHC Key Laboratory of the Study of Abnormal Gametes and the Reproductive Tract, Anhui Medical University, Hefei, China.
Key Laboratory of Population Health Across the Life Cycle, Anhui Medical University, Ministry of Education, the People's Republic of China, Hefei, China.
Anhui Province Key Laboratory of Reproductive Health and Genetics, Biopreservation and Artificial Organs, Hefei, China.
Anhui Provincial Engineering Research Center, Anhui Medical University, Hefei, China.
School of Public Health, Anhui Medical University, Hefei, China.

Meiguo Sun (M)

Department of Obstetrics and Gynecology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
NHC Key Laboratory of the Study of Abnormal Gametes and the Reproductive Tract, Anhui Medical University, Hefei, China.
Key Laboratory of Population Health Across the Life Cycle, Anhui Medical University, Ministry of Education, the People's Republic of China, Hefei, China.
Anhui Province Key Laboratory of Reproductive Health and Genetics, Biopreservation and Artificial Organs, Hefei, China.
Anhui Provincial Engineering Research Center, Anhui Medical University, Hefei, China.

Yueran Chen (Y)

Department of Obstetrics and Gynecology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
NHC Key Laboratory of the Study of Abnormal Gametes and the Reproductive Tract, Anhui Medical University, Hefei, China.
Key Laboratory of Population Health Across the Life Cycle, Anhui Medical University, Ministry of Education, the People's Republic of China, Hefei, China.
Anhui Province Key Laboratory of Reproductive Health and Genetics, Biopreservation and Artificial Organs, Hefei, China.
Anhui Provincial Engineering Research Center, Anhui Medical University, Hefei, China.

Yuanhua Chen (Y)

NHC Key Laboratory of the Study of Abnormal Gametes and the Reproductive Tract, Anhui Medical University, Hefei, China.
Key Laboratory of Population Health Across the Life Cycle, Anhui Medical University, Ministry of Education, the People's Republic of China, Hefei, China.
Anhui Province Key Laboratory of Reproductive Health and Genetics, Biopreservation and Artificial Organs, Hefei, China.
Anhui Provincial Engineering Research Center, Anhui Medical University, Hefei, China.
School of Public Health, Anhui Medical University, Hefei, China.

Yuanyuan Yang (Y)

Department of Obstetrics and Gynecology, First Affiliated Hospital of Anhui Medical University, Hefei, China. wlj69513@sina.com.
NHC Key Laboratory of the Study of Abnormal Gametes and the Reproductive Tract, Anhui Medical University, Hefei, China. wlj69513@sina.com.
Key Laboratory of Population Health Across the Life Cycle, Anhui Medical University, Ministry of Education, the People's Republic of China, Hefei, China. wlj69513@sina.com.
Anhui Province Key Laboratory of Reproductive Health and Genetics, Biopreservation and Artificial Organs, Hefei, China. wlj69513@sina.com.
Anhui Provincial Engineering Research Center, Anhui Medical University, Hefei, China. wlj69513@sina.com.

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Magnesium sulfate prophylaxis attenuates the...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Magnesium sulfate prophylaxis attenuates the...
questionsmedicales.fr › Produits chimiques inorganiques › Sulfates › Sulfate de magnésium › Magnesium sulfate prophylaxis attenuates the...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Période du postpartum › Magnesium sulfate prophylaxis attenuates the...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Pré-éclampsie › Magnesium sulfate prophylaxis attenuates the...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Magnesium sulfate prophylaxis attenuates the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Magnesium sulfate prophylaxis attenuates the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Magnesium sulfate prophylaxis attenuates the...