Cross-species chromatin interactions drive transcriptional rewiring in Epstein-Barr virus-positive gastric adenocarcinoma.
Journal
Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
03
08
2019
accepted:
17
06
2020
pubmed:
29
7
2020
medline:
30
10
2020
entrez:
29
7
2020
Statut:
ppublish
Résumé
Epstein-Barr virus (EBV) is associated with several human malignancies including 8-10% of gastric cancers (GCs). Genome-wide analysis of 3D chromatin topologies across GC lines, primary tissue and normal gastric samples revealed chromatin domains specific to EBV-positive GC, exhibiting heterochromatin-to-euchromatin transitions and long-range human-viral interactions with non-integrated EBV episomes. EBV infection in vitro suffices to remodel chromatin topology and function at EBV-interacting host genomic loci, converting H3K9me3
Identifiants
pubmed: 32719515
doi: 10.1038/s41588-020-0665-7
pii: 10.1038/s41588-020-0665-7
doi:
Substances chimiques
Chromatin
0
MAS1 protein, human
0
Proto-Oncogene Mas
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
919-930Références
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