Mechanisms of Axon Elongation Following CNS Injury: What Is Happening at the Axon Tip?
actin
axon regeneration
cytoskeletal dynamics
growth cone
microtubules
neurofilaments
spinal cord injury
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2020
2020
Historique:
received:
31
03
2020
accepted:
22
05
2020
entrez:
29
7
2020
pubmed:
29
7
2020
medline:
29
7
2020
Statut:
epublish
Résumé
After an injury to the central nervous system (CNS), functional recovery is limited by the inability of severed axons to regenerate and form functional connections with appropriate target neurons beyond the injury. Despite tremendous advances in our understanding of the mechanisms of axon growth, and of the inhibitory factors in the injured CNS that prevent it, disappointingly little progress has been made in restoring function to human patients with CNS injuries, such as spinal cord injury (SCI), through regenerative therapies. Clearly, the large number of overlapping neuron-intrinsic and -extrinsic growth-inhibitory factors attenuates the benefit of neutralizing any one target. More daunting is the distances human axons would have to regenerate to reach some threshold number of target neurons, e.g., those that occupy one complete spinal segment, compared to the distances required in most experimental models, such as mice and rats. However, the difficulties inherent in studying mechanisms of axon regeneration in the mature CNS
Identifiants
pubmed: 32719586
doi: 10.3389/fncel.2020.00177
pmc: PMC7347967
doi:
Types de publication
Journal Article
Langues
eng
Pagination
177Subventions
Organisme : NINDS NIH HHS
ID : R01 NS092876
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS095471
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS107586
Pays : United States
Informations de copyright
Copyright © 2020 Rodemer, Gallo and Selzer.
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