Mesenchymal Bmp7 Controls Onset of Tooth Mineralization: A Novel Way to Regulate Molar Cusp Shape.
bone morphogenetic protein
epithelial–mesenchymal interaction
gene expression
mouse genetics
signaling
tooth mineralization
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
04
2020
accepted:
28
05
2020
entrez:
29
7
2020
pubmed:
29
7
2020
medline:
29
7
2020
Statut:
epublish
Résumé
Investigating the molecular basis for tooth shape variation provides an important glimpse into the evolution of tooth function. We recently showed that loss of mesenchymal BMP7 is sufficient to alter morphology and function of the toothrow. Here we report on the underlying mechanism. Expression of mesenchymal Bmp7 is observed at sites where mineralization is initiated, in tooth cusps of developing molars. Neural crest-specific deletion of
Identifiants
pubmed: 32719613
doi: 10.3389/fphys.2020.00698
pmc: PMC7350786
doi:
Types de publication
Journal Article
Langues
eng
Pagination
698Informations de copyright
Copyright © 2020 Malik, Roth, Eaton, Theodor and Graf.
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