Comparison between the impact of fermented and unfermented soy intake on the risk of liver cancer: the JPHC Study.
Cohort study
Japan
Liver cancer
Soy
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
03
09
2019
accepted:
13
07
2020
pubmed:
29
7
2020
medline:
24
6
2021
entrez:
29
7
2020
Statut:
ppublish
Résumé
The aim of this study was to compare the impact of fermented and unfermented soy intake, based on the following soy-derived products: tofu, soymilk, natto, and miso, on the risk of liver cancer among Japanese adults. 75,089 Participants of the Japan Public Health Center-based Prospective Study (JPHC Study) were followed from the time of the 5-year follow-up questionnaire until the end of 2012-2013. Subjects with available data on hepatitis B virus (HBV) and hepatitis C virus (HCV) infection status from blood samples (n = 14,016) and those who were anti-HCV antibody (anti-HCV) or hepatitis B virus antigen (HBsAg) positive (n = 1033) were also analyzed separately. Cox proportional hazard models were employed to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs). During 1,145,453 person-years, 534 newly diagnosed cases of liver cancer were identified in the JPHC Study. For miso intake among men, the multivariate-adjusted highest versus lowest quartile HR was 0.65 (95% CI, 0.48-0.89); p for trend = 0.006. Results were similar in those who were anti-HCV or HBsAg positive, 0.24 (0.08-0.70); p for trend = 0.004 highest versus lowest tertile. For the sub-analysis among only participants with known hepatitis infection status and HCV and HBsAg adjustment, a similar association was observed. In the multivariate complete cohort analysis, among women, the highest intake of fried tofu was inversely associated with the risk of liver cancer, HR = 0.45 (0.26-0.80); p for trend = 0.014. We observed no association between total soy intake, fermented and unfermented, and risk of liver cancer, and only an inverse association between miso intake and liver cancer among men.
Identifiants
pubmed: 32719984
doi: 10.1007/s00394-020-02335-9
pii: 10.1007/s00394-020-02335-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1389-1401Subventions
Organisme : National Cancer Center Research and Development Fund
ID : 29-A-4, 26-A-2, 23-A-31 [toku]
Organisme : Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare in Japan
ID : from 1989 to 2010
Organisme : Ministry of Agriculture, Fishery and Forestry of Japan
ID : MAFF-CPS-2016-1-1
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