Patterns of Recurrence in Locally Advanced Resectable Oesophageal Carcinoma: Retrospective Review from a Tertiary Cancer Centre in South India.
Adult
Aged
Cancer Care Facilities
/ statistics & numerical data
Carcinoma
/ diagnosis
Disease-Free Survival
Esophageal Neoplasms
/ diagnosis
Esophagectomy
Esophagus
/ pathology
Female
Follow-Up Studies
Humans
India
/ epidemiology
Male
Margins of Excision
Middle Aged
Neoadjuvant Therapy
/ methods
Neoplasm Recurrence, Local
/ epidemiology
Radiotherapy, Adjuvant
/ methods
Retrospective Studies
Tertiary Care Centers
/ statistics & numerical data
Elective nodal irradiation
In-field recurrence
Locally advanced carcinoma oesophagus
Neoadjuvant concurrent chemoradiation
Oesophagus CTV
Journal
Journal of gastrointestinal cancer
ISSN: 1941-6636
Titre abrégé: J Gastrointest Cancer
Pays: United States
ID NLM: 101479627
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
pubmed:
29
7
2020
medline:
7
9
2021
entrez:
29
7
2020
Statut:
ppublish
Résumé
The study aims to analyse patterns of recurrence following neoadjuvant treatment and surgery in carcinoma oesophagus with an intent to postulate optimal nodal radiation. A retrospective review of patients who presented to our centre within a 5-year period (2014-2018), with recurrence following sequential neoadjuvant treatment and radical surgery, was conducted in this single-institution study. The patterns of recurrence and duration of disease-free survival were analysed. Twenty-one patients (14 men, 7 women) presented with recurrence, of which 13, 7, and 1 patient(s) had received NACT, NACTRT, or both, respectively. Six patients who did not receive neoadjuvant radiotherapy received adjuvant RT. Among the 10 patients who had nodal recurrence after RT (either neoadjuvant or adjuvant), 6 and 4 patients had in-field and out-of-field nodal recurrences, respectively-the latter were equally distributed within 5 cm and outside 5 cm of the PTV margin. Among the patients who presented with recurrence, more than half had not received neoadjuvant RT (treated in the 'pre-CROSS era' or due to long-segment disease), reasserting the therapeutic superiority of NACTRT. Increased regularity of recurrences in the draining nodal region was not noted in this study, but large-scale, prospective, randomised head-to-head comparative trials to determine optimal nodal irradiation in carcinoma oesophagus are required.
Identifiants
pubmed: 32720121
doi: 10.1007/s12029-020-00464-2
pii: 10.1007/s12029-020-00464-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
711-718Références
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