Growth-factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development.
blastocyst
cell fate
cell numbers
developmental biology
imaging
modeling
mouse
mouse embryo
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
28 07 2020
28 07 2020
Historique:
received:
16
02
2020
accepted:
24
07
2020
pubmed:
29
7
2020
medline:
24
2
2021
entrez:
29
7
2020
Statut:
epublish
Résumé
Precise control and maintenance of population size is fundamental for organismal development and homeostasis. The three cell types of the mammalian blastocyst are generated in precise proportions over a short time, suggesting a mechanism to ensure a reproducible outcome. We developed a minimal mathematical model demonstrating growth factor signaling is sufficient to guarantee this robustness and which anticipates an embryo's response to perturbations in lineage composition. Addition of lineage-restricted cells both in vivo and in silico, causes a shift of the fate of progenitors away from the supernumerary cell type, while eliminating cells using laser ablation biases the specification of progenitors toward the targeted cell type. Finally, FGF4 couples fate decisions to lineage composition through changes in local growth factor concentration, providing a basis for the regulative abilities of the early mammalian embryo whereby fate decisions are coordinated at the population level to robustly generate tissues in the right proportions.
Identifiants
pubmed: 32720894
doi: 10.7554/eLife.56079
pii: 56079
pmc: PMC7513828
doi:
pii:
Substances chimiques
Intercellular Signaling Peptides and Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Spanish Ministry of Science, Innovation and Universities
ID : PGC2018-101251-B-I00
Pays : International
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD094868
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK084391
Pays : United States
Organisme : Spanish Ministry of Science, Innovation and Universities
ID : CEX2018-000792-M
Pays : International
Informations de copyright
© 2020, Saiz et al.
Déclaration de conflit d'intérêts
NS, LM, SR, HG, JH, JG, AH No competing interests declared
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