Results from the TRIBE-AKI Study found associations between post-operative blood biomarkers and risk of chronic kidney disease after cardiac surgery.
CKD
biomarkers
cardiac surgery
subclinical AKI
Journal
Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
06
01
2020
revised:
15
06
2020
accepted:
26
06
2020
pubmed:
30
7
2020
medline:
22
6
2021
entrez:
30
7
2020
Statut:
ppublish
Résumé
Patients undergoing cardiac surgery are placed under intense physiologic stress. Blood and urine biomarkers measured peri-operatively may help identify patients at higher risk for adverse long-term kidney outcomes.We sought to determine independent associations of various biomarkers with development or progression of chronic kidney disease (CKD) following cardiac surgery. In this sub-study of the prospective cohort -TRIBE-AKI Study, we evaluated 613 adult patients undergoing cardiac surgery in Canada in our primary analysis and tested the association of 40 blood and urinary biomarkers with the primary composite outcome of CKD incidence or progression. In those with baseline estimated glomerular filtration rate (eGFR) over 60 mL/min/1.73m
Identifiants
pubmed: 32721447
pii: S0085-2538(20)30831-0
doi: 10.1016/j.kint.2020.06.037
pmc: PMC8077034
mid: NIHMS1687273
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
716-724Subventions
Organisme : NHLBI NIH HHS
ID : T32 HL007024
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK117065
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079310
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113191
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK082185
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL085757
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK115562
Pays : United States
Organisme : NIDDK NIH HHS
ID : K24 DK090203
Pays : United States
Organisme : NIOSH CDC HHS
ID : U01 OH011326
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK112258
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK113420
Pays : United States
Informations de copyright
Copyright © 2020 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
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