What is the optimal loading dose of broad-spectrum β-lactam antibiotics in septic patients? Results from pharmacokinetic simulation modelling.
Anti-Bacterial Agents
/ pharmacokinetics
Cefepime
/ pharmacokinetics
Ceftazidime
/ pharmacokinetics
Computer Simulation
Humans
Meropenem
/ pharmacokinetics
Microbial Sensitivity Tests
Monte Carlo Method
Piperacillin
/ pharmacokinetics
Prospective Studies
Pseudomonas aeruginosa
/ drug effects
Shock, Septic
/ drug therapy
beta-Lactams
/ pharmacokinetics
Loading dose
Monte Carlo simulation
Pharmacokinetics
Sepsis
β-Lactams
Journal
International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
28
01
2020
revised:
25
06
2020
accepted:
19
07
2020
pubmed:
30
7
2020
medline:
28
5
2021
entrez:
30
7
2020
Statut:
ppublish
Résumé
Optimal loading doses of β-lactams to rapidly achieve adequate drug concentrations in critically ill patients are unknown. This was a post-hoc analysis of a prospective study that evaluated broad-spectrum β-lactams [piperacillin (PIP), ceftazidime (CAZ), cefepime (FEP) and meropenem (MEM)] pharmacokinetics (PKs) in patients with sepsis or septic shock (n = 88). Monte Carlo simulation was performed for 1000 virtual patients using specific sets of covariates for various dosing regimens and different durations of administration. Pharmacodynamic (PD) targets were considered as drug concentrations exceeding at least 50% of time above four times the minimum inhibitory concentration (T
Identifiants
pubmed: 32721604
pii: S0924-8579(20)30296-X
doi: 10.1016/j.ijantimicag.2020.106113
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
beta-Lactams
0
Cefepime
807PW4VQE3
Ceftazidime
9M416Z9QNR
Meropenem
FV9J3JU8B1
Piperacillin
X00B0D5O0E
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106113Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.