Can cerebral lateralisation explain heterogeneity in language and increased non-right handedness in autism? A literature review.
Autism
Cerebral lateralisation
Handedness
Language
Journal
Research in developmental disabilities
ISSN: 1873-3379
Titre abrégé: Res Dev Disabil
Pays: United States
ID NLM: 8709782
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
14
04
2019
revised:
06
07
2020
accepted:
10
07
2020
pubmed:
30
7
2020
medline:
29
7
2021
entrez:
30
7
2020
Statut:
ppublish
Résumé
Autism is characterised by phenotypic variability, particularly in the domains of language and handedness. However, the source of this heterogeneity is currently unclear. To synthesise findings regarding the relationship between language, handedness, and cerebral lateralisation in autistic people and consider how future research should be conducted in order to progress our understanding of phenotypic variability. Following a literature search and selection process, 19 papers were included in this literature review. Studies using behavioural, structural, and functional measures of lateralisation are reviewed. The studies reviewed provided consistent evidence of differential cerebral lateralisation in autistic people, and this appears to be related to between-group differences in language. Evidence relating this to handedness was less consistent. Many of the studies did not include heterogeneous samples, and/or did not specify the language process they investigated. This review suggests that further research is needed to fully understand the relationship between cerebral lateralisation and phenotypic variability within autism. It is crucial that future studies in this area include heterogeneous samples, specify the language process they are investigating, and consider taking developmental trajectories into account.
Sections du résumé
BACKGROUND
BACKGROUND
Autism is characterised by phenotypic variability, particularly in the domains of language and handedness. However, the source of this heterogeneity is currently unclear.
AIMS
OBJECTIVE
To synthesise findings regarding the relationship between language, handedness, and cerebral lateralisation in autistic people and consider how future research should be conducted in order to progress our understanding of phenotypic variability.
METHODS AND PROCEDURES
METHODS
Following a literature search and selection process, 19 papers were included in this literature review. Studies using behavioural, structural, and functional measures of lateralisation are reviewed.
OUTCOMES AND RESULTS
RESULTS
The studies reviewed provided consistent evidence of differential cerebral lateralisation in autistic people, and this appears to be related to between-group differences in language. Evidence relating this to handedness was less consistent. Many of the studies did not include heterogeneous samples, and/or did not specify the language process they investigated.
CONCLUSIONS AND IMPLICATIONS
CONCLUSIONS
This review suggests that further research is needed to fully understand the relationship between cerebral lateralisation and phenotypic variability within autism. It is crucial that future studies in this area include heterogeneous samples, specify the language process they are investigating, and consider taking developmental trajectories into account.
Identifiants
pubmed: 32721786
pii: S0891-4222(20)30168-2
doi: 10.1016/j.ridd.2020.103738
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
103738Informations de copyright
Crown Copyright © 2020. Published by Elsevier Ltd. All rights reserved.