An overview of the role of interleukin-8 in colorectal cancer.
Colorectal Cancer
IL-8
Metastasis
Signaling Pathway
Therapy
Journal
Cytokine
ISSN: 1096-0023
Titre abrégé: Cytokine
Pays: England
ID NLM: 9005353
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
01
03
2020
revised:
08
07
2020
accepted:
09
07
2020
pubmed:
30
7
2020
medline:
15
12
2021
entrez:
30
7
2020
Statut:
ppublish
Résumé
Colorectal Cancer (CRC), a common malignancy, is developing globally among people. Mutagenic insults activate peripheral nucleated cells to secrete chemokines in order to cause an inflammatory state. Despite the presence of multi-retrieving factors, elevated production of minor cytokines may speed-up the sever stages of the baseline inflammation targeting normal compensatory mechanism. IL-8 is a pro-inflammatory cytokine that is believed to be up-regulated in CRC to proceed primary condition into tumor behavior via induction of proliferation, angiogenesis and metastasis. Here, we assess the role of IL-8 in every step of CRC from signaling pathway and formation to invasion and discuss around new perspective therapy that targets IL-8 to manage CRC worldwide incidence and survival rate, more precisely.
Identifiants
pubmed: 32721849
pii: S1043-4666(20)30221-0
doi: 10.1016/j.cyto.2020.155205
pii:
doi:
Substances chimiques
Cytokines
0
Interleukin-8
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
155205Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.