Gut Microbiome and AKI: Roles of the Immune System and Short-Chain Fatty Acids.

Acute Kidney Injury / immunology Fatty Acids, Volatile / metabolism Gastrointestinal Microbiome Humans
Acute kidney injury Gut microbiota Ischemia reperfusion Short-chain fatty acids T cells

Journal

Nephron
ISSN: 2235-3186
Titre abrégé: Nephron
Pays: Switzerland
ID NLM: 0331777

Informations de publication

Date de publication:
2020
Historique:
received: 06 05 2020
accepted: 26 05 2020
pubmed: 30 7 2020
medline: 27 10 2021
entrez: 30 7 2020
Statut: ppublish

Résumé

Acute kidney injury (AKI) is a common and serious syndrome that involves multiple pathophysiologic mechanisms. Recent studies have demonstrated that dysbiosis of the gut microbiota mediates experimental AKI. The precise microbial populations involved and the underlying mechanisms are currently being explored. In this mini-review based on the NIH AKI O'Brien Center symposium of February 2020, we discuss data on gut microbiota in AKI with a focus on the immune system and short-chain fatty acids as mediators of microbiome-kidney crosstalk.

Identifiants

DOI: 10.1159/000508984 PMID: 32721962
pubmed: 32721962
pii: 000508984
doi: 10.1159/000508984
doi:

Substances chimiques

Fatty Acids, Volatile 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

662-664

Informations de copyright

© 2020 S. Karger AG, Basel.

Auteurs

Sepideh Gharaie (S)

Division of Nephrology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Sanjeev Noel (S)

Division of Nephrology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Hamid Rabb (H)

Division of Nephrology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA, hrabb1@jhmi.edu.

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Classifications MeSH

questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Insuffisance rénale › Atteinte rénale aigüe › Gut Microbiome and AKI: Roles of the Immune...
questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Gut Microbiome and AKI: Roles of the Immune...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Gut Microbiome and AKI: Roles of the Immune...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gut Microbiome and AKI: Roles of the Immune...