Hippo Signaling Pathway as a Central Mediator of Receptors Tyrosine Kinases (RTKs) in Tumorigenesis.
Hippo signaling
TAZ
YAP
receptor tyrosine kinases (RTKs)
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
24 Jul 2020
24 Jul 2020
Historique:
received:
03
07
2020
revised:
21
07
2020
accepted:
22
07
2020
entrez:
30
7
2020
pubmed:
30
7
2020
medline:
30
7
2020
Statut:
epublish
Résumé
The Hippo pathway plays a critical role in tissue and organ growth under normal physiological conditions, and its dysregulation in malignant growth has made it an attractive target for therapeutic intervention in the fight against cancer. To date, its complex signaling mechanisms have made it difficult to identify strong therapeutic candidates. Hippo signaling is largely carried out by two main activated signaling pathways involving receptor tyrosine kinases (RTKs)-the RTK/RAS/PI3K and the RTK-RAS-MAPK pathways. However, several RTKs have also been shown to regulate this pathway to engage downstream Hippo effectors and ultimately influence cell proliferation. In this text, we attempt to review the diverse RTK signaling pathways that influence Hippo signaling in the context of oncogenesis.
Identifiants
pubmed: 32722184
pii: cancers12082042
doi: 10.3390/cancers12082042
pmc: PMC7463967
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : CIHR
ID : 377104
Pays : Canada
Organisme : Canadian Cancer Society-Innovation Grant
ID : 705973
Organisme : Canadian Cancer Society- Impact Grant
ID : 706162
Références
PLoS Genet. 2017 Nov 6;13(11):e1007091
pubmed: 29108021
Mol Cancer Res. 2018 Jun;16(6):1046-1058
pubmed: 29545474
Nat Commun. 2018 Mar 13;9(1):1061
pubmed: 29535383
Nat Cell Biol. 2009 Dec;11(12):1444-50
pubmed: 19935651
J Biol Chem. 2001 Jun 1;276(22):19276-85
pubmed: 11278283
Biomaterials. 2013 Nov;34(34):8690-707
pubmed: 23953842
Cell Death Differ. 2019 Dec;26(12):2577-2593
pubmed: 30903103
J Biol Chem. 2016 Apr 8;291(15):8031-47
pubmed: 26826125
Oncotarget. 2015 Feb 28;6(6):4357-68
pubmed: 25738359
Circ Res. 2015 Jan 2;116(1):35-45
pubmed: 25249570
Mol Cancer. 2018 Feb 19;17(1):30
pubmed: 29455642
Nat Commun. 2015 May 12;6:6943
pubmed: 25962877
Oncogene. 2005 Mar 17;24(12):2076-86
pubmed: 15688006
Cells. 2019 May 01;8(5):
pubmed: 31052445
Cell Prolif. 2018 Aug;51(4):e12453
pubmed: 29504176
Biochem Biophys Res Commun. 2008 Feb 8;366(2):471-5
pubmed: 18067853
Cell Signal. 2018 Dec;52:12-22
pubmed: 30138697
J Clin Invest. 2018 Mar 1;128(3):1010-1025
pubmed: 29400692
Genes Dev. 2010 Feb 1;24(3):290-300
pubmed: 20123908
Curr Biol. 2006 Nov 7;16(21):2090-100
pubmed: 16996265
Sci Rep. 2018 Jan 10;8(1):271
pubmed: 29321482
Sci Rep. 2019 Dec 23;9(1):19704
pubmed: 31873172
Cancer Cell. 2018 Feb 12;33(2):292-308.e7
pubmed: 29438698
J Thorac Dis. 2011 Mar;3(1):10-8
pubmed: 22263058
Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18034-9
pubmed: 16332960
FASEB J. 2019 Nov;33(11):12487-12499
pubmed: 31431076
Cell. 1997 Mar 7;88(5):593-602
pubmed: 9054499
Curr Opin Oncol. 2008 Mar;20(2):183-9
pubmed: 18300768
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Cell. 2006 Aug 25;126(4):663-76
pubmed: 16904174
Genes Dev. 2013 Feb 15;27(4):355-71
pubmed: 23431053
Cell Rep. 2018 Oct 30;25(5):1304-1317.e5
pubmed: 30380420
Oncotarget. 2018 Aug 3;9(60):31620-31636
pubmed: 30167083
Sci Signal. 2014 Dec 09;7(355):ra116
pubmed: 25492965
Oncogene. 2018 May;37(22):3022-3038
pubmed: 29535422
Endocr Relat Cancer. 2015 Jun;22(3):443-54
pubmed: 25870251
Cell Signal. 2014 Feb;26(2):186-91
pubmed: 24216612
Cancer Res. 2014 Aug 15;74(16):4493-503
pubmed: 24812269
Circ Res. 2018 Feb 16;122(4):591-605
pubmed: 29298775
J Proteome Res. 2014 Jun 6;13(6):2874-86
pubmed: 24766643
Mol Cancer Res. 2017 Jul;15(7):929-941
pubmed: 28360038
Cancer Discov. 2018 Aug;8(8):1026-1043
pubmed: 29907586
Exp Cell Res. 2018 Oct 1;371(1):63-71
pubmed: 30056064
Cancer Discov. 2015 Nov;5(11):1178-93
pubmed: 26359368
Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2569-74
pubmed: 23359693
Oncogene. 2003 Oct 9;22(44):6942-5
pubmed: 14534542
Mol Biol Cell. 2015 Nov 5;26(22):3946-53
pubmed: 26337386
Pharmacol Res. 2014 Jan;79:34-74
pubmed: 24269963
Genes Dev. 2010 Jun 1;24(11):1106-18
pubmed: 20516196
CA Cancer J Clin. 2020 Jan;70(1):7-30
pubmed: 31912902
Nat Cell Biol. 2015 Apr;17(4):362-3
pubmed: 25812520
Cell. 2014 Jul 3;158(1):171-84
pubmed: 24954536
Dev Biol. 2012 Jul 15;367(2):187-96
pubmed: 22609549
Neurosci Res. 2006 Dec;56(4):450-8
pubmed: 17049657
Mol Carcinog. 2007 Oct;46(10):865-71
pubmed: 17538946
Clin Transl Med. 2018 Aug 13;7(1):23
pubmed: 30101371
Cancer Cell. 2012 Jan 17;21(1):66-81
pubmed: 22264789
Nature. 2001 May 17;411(6835):355-65
pubmed: 11357143
Cell Death Dis. 2018 Feb 15;9(3):269
pubmed: 29449645
Ther Adv Med Oncol. 2011 Nov;3(1 Suppl):S3-5
pubmed: 22128286
Cancer Cell. 2014 Jun 16;25(6):831-45
pubmed: 24882515
Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4870-5
pubmed: 21383157
Sci Signal. 2014 May 06;7(324):ra42
pubmed: 24803537
Biochem Biophys Res Commun. 2016 May 20;474(1):154-160
pubmed: 27105908
Cell. 2000 Oct 13;103(2):211-25
pubmed: 11057895
Cancer Res. 2008 Apr 15;68(8):2592-8
pubmed: 18413727
J Biol Chem. 2011 Mar 11;286(10):7788-96
pubmed: 21233212
Oncogene. 2019 Apr;38(15):2778-2787
pubmed: 30542115
Curr Biol. 2008 Mar 11;18(5):311-21
pubmed: 18328708
Cell Rep. 2014 Oct 23;9(2):495-503
pubmed: 25373897
Oncogene. 2016 Apr 28;35(17):2247-65
pubmed: 26364602
Cytokine Growth Factor Rev. 2004 Dec;15(6):419-33
pubmed: 15561600
Cancers (Basel). 2019 Oct 19;11(10):
pubmed: 31635084
Cancer Res. 2010 Feb 1;70(3):1195-203
pubmed: 20086174
Am J Cancer Res. 2016 May 01;6(5):996-1010
pubmed: 27293994
Cell Prolif. 2007 Aug;40(4):580-94
pubmed: 17635524
Gut. 2003 May;52(5):706-12
pubmed: 12692057
Cell Biosci. 2015 Feb 05;5:7
pubmed: 25973173
Nat Rev Cancer. 2010 Mar;10(3):165-80
pubmed: 20179713
Nat Cell Biol. 2015 Apr;17(4):500-10
pubmed: 25751140
Nat Cell Biol. 2014 Jan;16(1):108-17
pubmed: 24362629
J Cell Sci. 2011 Apr 1;124(Pt 7):1136-44
pubmed: 21385842
Trends Biochem Sci. 2010 Aug;35(8):427-33
pubmed: 20570523
J Biol Chem. 2003 Aug 29;278(35):33334-41
pubmed: 12807903
Genes Dev. 2007 Nov 1;21(21):2747-61
pubmed: 17974916
Exp Eye Res. 2018 Apr;169:122-133
pubmed: 29355736
Cancer Res. 2011 Apr 1;71(7):2728-38
pubmed: 21349946
Nat Cell Biol. 2014 Jul;16(7):673-84
pubmed: 24929361
Nat Cell Biol. 2015 Apr;17(4):490-9
pubmed: 25751139
Cell. 2015 Nov 5;163(4):811-28
pubmed: 26544935
EMBO Rep. 2014 Jun;15(6):642-56
pubmed: 24825474
Genes Dev. 2011 Apr 15;25(8):814-30
pubmed: 21498571
Dev Cell. 2017 Sep 11;42(5):462-478.e7
pubmed: 28867486
Am J Respir Cell Mol Biol. 2019 Jan;60(1):117-127
pubmed: 30156429
J Exp Clin Cancer Res. 2018 Aug 22;37(1):198
pubmed: 30134988
Nat Mater. 2020 Jun;19(6):669-678
pubmed: 31907416
Biofactors. 2009 Jul-Aug;35(4):338-45
pubmed: 19484742
Annu Rev Genet. 2018 Nov 23;52:65-87
pubmed: 30183404
Curr Biol. 2010 Apr 13;20(7):582-90
pubmed: 20362445
Mol Cell Biol. 2008 Apr;28(7):2426-36
pubmed: 18227151
J Am Soc Nephrol. 2016 Jun;27(6):1689-700
pubmed: 26453611
Cancer Biol Ther. 2008 May;7(5):740-1
pubmed: 18443426
Science. 2004 Dec 24;306(5705):2267-70
pubmed: 15618521
Sci Signal. 2017 Dec 05;10(508):
pubmed: 29208682
Cell Rep. 2017 Mar 7;18(10):2464-2479
pubmed: 28273460
Biochem J. 2009 May 27;420(3):345-61
pubmed: 19459784
J Vis Exp. 2018 Sep 13;(139):
pubmed: 30272653
Oncol Rep. 2017 Aug;38(2):1199-1205
pubmed: 28677804
Mol Cell Biol. 2010 Feb;30(3):711-21
pubmed: 19995908
Clin Cancer Res. 2015 Jun 1;21(11):2580-90
pubmed: 25739674
Trends Cell Biol. 2010 Jul;20(7):410-7
pubmed: 20452772
Cancer Res. 2002 Nov 15;62(22):6451-5
pubmed: 12438234
CA Cancer J Clin. 2015 Mar;65(2):87-108
pubmed: 25651787
Dev Cell. 2013 Mar 11;24(5):459-71
pubmed: 23484853
Biochem J. 2001 Jul 1;357(Pt 1):297-303
pubmed: 11415463
Sci Rep. 2019 Apr 5;9(1):5740
pubmed: 30952872
PLoS One. 2013 Jun 10;8(6):e65539
pubmed: 23762387
Oral Oncol. 2018 Apr;79:55-63
pubmed: 29598951
EMBO Mol Med. 2015 Sep 28;7(11):1426-49
pubmed: 26417066
Sci Signal. 2012 Nov 06;5(249):pe49
pubmed: 23131845
Science. 2002 Oct 18;298(5593):597-600
pubmed: 12228720
Cell. 1990 Apr 20;61(2):203-12
pubmed: 2158859
Cell. 2018 Apr 5;173(2):321-337.e10
pubmed: 29625050
Cancer Res. 2002 Dec 1;62(23):7001-3
pubmed: 12460919
Clin Cancer Res. 2015 Nov 15;21(22):5002-7
pubmed: 26384319
Oncogene. 2000 Nov 20;19(49):5548-57
pubmed: 11114734
Oncogene. 2020 Jan;39(2):334-355
pubmed: 31477837
N Engl J Med. 2010 Apr 8;362(14):1273-81
pubmed: 20375404
Mol Biol Cell. 2011 Oct;22(19):3725-33
pubmed: 21832154
Tissue Barriers. 2015 Apr 03;3(1-2):e957508
pubmed: 25838975
Nat Rev Genet. 2006 Aug;7(8):606-19
pubmed: 16847462
J Cell Biochem. 2018 Jan;119(1):824-836
pubmed: 28661054
Clin Lung Cancer. 2007 Jan;8(4):273-6
pubmed: 17311693