Targeted Therapies in Advanced Biliary Tract Cancer: An Evolving Paradigm.
biliary tract cancer
cholangiocarcinoma
circulating tumor DNA (ctDNA)
gallbladder cancer
ivosidenib
molecular profiling
next-generation sequencing
pemigatinib
targeted therapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
24 Jul 2020
24 Jul 2020
Historique:
received:
30
06
2020
revised:
21
07
2020
accepted:
23
07
2020
entrez:
30
7
2020
pubmed:
30
7
2020
medline:
30
7
2020
Statut:
epublish
Résumé
Biliary tract cancers (BTCs) are a heterogeneous group of adenocarcinomas that originate from the epithelial lining of the biliary tree. BTCs are characterized by presentation with advanced disease precluding curative surgery, rising global incidence, and a poor prognosis. Chemotherapy is the mainstay of the current treatment, which results in a median overall survival of less than one year, underscoring the need for novel therapeutic agents and strategies. Next-generation sequencing-based molecular profiling has shed light on the underpinnings of the complex pathophysiology of BTC and has uncovered numerous actionable targets, leading to the discovery of new therapies tailored to the molecular targets. Therapies targeting fibroblast growth factor receptor (FGFR) fusion, isocitrate dehydrogenase (IDH) mutations, the human epidermal growth factor receptor (HER) family, DNA damage repair (DDR) pathways, and
Identifiants
pubmed: 32722188
pii: cancers12082039
doi: 10.3390/cancers12082039
pmc: PMC7465131
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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