Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases.
DGKs
PI3K/Akt/mTOR
cancer
diacylglycerol
lipids
phosphoinositide
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
26 Jul 2020
26 Jul 2020
Historique:
received:
24
06
2020
revised:
21
07
2020
accepted:
24
07
2020
entrez:
30
7
2020
pubmed:
30
7
2020
medline:
20
2
2021
Statut:
epublish
Résumé
An increasing number of reports suggests a significant involvement of the phosphoinositide (PI) cycle in cancer development and progression. Diacylglycerol kinases (DGKs) are very active in the PI cycle. They are a family of ten members that convert diacylglycerol (DAG) into phosphatidic acid (PA), two-second messengers with versatile cellular functions. Notably, some DGK isoforms, such as DGKα, have been reported to possess promising therapeutic potential in cancer therapy. However, further studies are needed in order to better comprehend their involvement in cancer. In this review, we highlight that DGKs are an essential component of the PI cycle that localize within several subcellular compartments, including the nucleus and plasma membrane, together with their PI substrates and that they are involved in mediating major cancer cell mechanisms such as growth and metastasis. DGKs control cancer cell survival, proliferation, and angiogenesis by regulating Akt/mTOR and MAPK/ERK pathways. In addition, some DGKs control cancer cell migration by regulating the activities of the Rho GTPases Rac1 and RhoA.
Identifiants
pubmed: 32722576
pii: ijms21155297
doi: 10.3390/ijms21155297
pmc: PMC7432101
pii:
doi:
Substances chimiques
1,2-diacylglycerol
0
Diglycerides
0
Neoplasm Proteins
0
Diacylglycerol Kinase
EC 2.7.1.107
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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