Association of rs662799 variant and APOA5 gene haplotypes with metabolic syndrome and its components: a meta-analysis in North Africa.
Adult
Apolipoprotein A-V
/ genetics
Black People
/ genetics
Case-Control Studies
Female
Genetic Association Studies
Genetic Predisposition to Disease
Haplotypes
Humans
Linkage Disequilibrium
Male
Metabolic Syndrome
/ diagnosis
Middle Aged
Phenotype
Polymorphism, Single Nucleotide
Risk Assessment
Risk Factors
Sex Factors
Tunisia
/ epidemiology
APOA5 Gene
Metabolic Syndrome
North Africa
Tunisia
genetic association
polymorphisms
Journal
Bioscience reports
ISSN: 1573-4935
Titre abrégé: Biosci Rep
Pays: England
ID NLM: 8102797
Informations de publication
Date de publication:
28 08 2020
28 08 2020
Historique:
received:
19
03
2020
revised:
14
05
2020
accepted:
20
05
2020
pubmed:
30
7
2020
medline:
30
3
2021
entrez:
30
7
2020
Statut:
ppublish
Résumé
Apolipoprotein A5 (APOA5) has been linked to metabolic syndrome (MetS) in several populations. In North Africa, only the Tunisian and Moroccan populations were investigated. Our aim is to assess the association between APOA5 gene variant (rs662799) and haplotypes with MetS in Tunisian population and to perform a meta-analysis in North Africa. A total of 594 Tunisian participants were genotyped for polymorphism rs662799 using KASPar technology. Two polymorphisms rs3135506 and rs651821 in APOA5 gene genotyped in our previous study, were used in addition to rs662799 to assess the haplotype association with MetS. The genotype of 875 participants was used for the meta-analysis. Statistical analyses were performed with R software. The rs662799 increases the risk of MetS under the dominant (P=0.018) and the additive models (P=0.028) in the Tunisian population. After stratification of the cohort following the sex and the geographic origin, a positive association of rs662799 with MetS was found for participant from the Northern region and for the women group. Only the haplotype AGT showed a significant association with MetS by decreasing the risk of the disease. The meta-analysis reported a significant association of rs662799 and rs3135506 with MetS. Our results showed a significant association between the APOA5 gene variants rs662799 and haplotypes with MetS and its traits in Tunisia. An impact of the sex and the geographic origin on the genotype distribution was highlighted. Our funding emphasizes the role of APOA5 in the development of MetS in North Africa.
Identifiants
pubmed: 32725151
pii: 225924
doi: 10.1042/BSR20200706
pmc: PMC7426633
pii:
doi:
Substances chimiques
APOA5 protein, human
0
Apolipoprotein A-V
0
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2020 The Author(s).
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