A history of antimicrobial drugs in animals: Evolution and revolution.
antimicrobials
history
veterinary medicine
Journal
Journal of veterinary pharmacology and therapeutics
ISSN: 1365-2885
Titre abrégé: J Vet Pharmacol Ther
Pays: England
ID NLM: 7910920
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
19
11
2019
revised:
08
06
2020
accepted:
06
07
2020
pubmed:
30
7
2020
medline:
25
11
2021
entrez:
30
7
2020
Statut:
ppublish
Résumé
The evolutionary process of antimicrobial drug (AMD) uses in animals over a mere eight decades (1940-2020) has led to a revolutionary outcome, and both evolution and revolution are ongoing, with reports on a range of uses, misuses and abuses escalating logarithmically. As well as veterinary therapeutic perspectives (efficacy, safety, host toxicity, residues, selection of drug, determination of dose and measurement of outcome in treating animal diseases), there are also broader, nontherapeutic uses, some of which have been abandoned, whilst others hopefully will soon be discontinued, at least in more developed countries. Although AMD uses for treatment of animal diseases will continue, it must: (a) be sustainable within the One Health paradigm; and (b) devolve into more prudent, rationally based therapeutic uses. As this review on AMDs is published in a Journal of Pharmacology and Therapeutics, its scope has been made broader than most recent reviews in this field. Many reviews have focused on negative aspects of AMD actions and uses, especially on the question of antimicrobial resistance. This review recognizes these concerns but also emphasizes the many positive aspects deriving from the use of AMDs, including the major research-based advances underlying both the prudent and rational use of AMDs. It is structured in seven sections: (1) Introduction; (2) Sulfonamide history; (3) Nontherapeutic and empirical uses of AMDs (roles of agronomists and veterinarians); (4) Rational uses of AMDs (roles of pharmacologists, clinicians, industry and regulatory controls); (5) Prudent use (residue monitoring, antimicrobial resistance); (6) International and inter-disciplinary actions; and (7) Conclusions.
Substances chimiques
Anti-Bacterial Agents
0
Anti-Infective Agents
0
Pharmaceutical Preparations
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
137-171Informations de copyright
© 2020 The Authors. Journal of Veterinary Pharmacology and Therapeutics published by John Wiley & Sons Ltd.
Références
Aarestrup, F. M. (1995). Occurrence of glycopeptide resistance among Enterococcus faecium isolates from conventional and ecological poultry farms. Microbial Drug Resistance, 1(3), 255-257. https://doi.org/10.1089/mdr.1995.1.255
Aarestrup, F. M. (1999). Association between the consumption of antimicrobial agents in animal husbandry and the occurrence of resistant bacteria among food animals. International Journal of Antimicrobial Agents, 12(4), 279-285. https://doi.org/10.1016/S0924-8579(99)90059-6
Aarestrup, F. M., Ahrens, P., Madsen, M., Pallesen, L. V., Poulsen, R. L., & Westh, H. (1996). Glycopeptide susceptibility among Danish Enterococcus faecium and Enterococcus faecalis isolates of animal and human origin and PCR identification of genes within the VanA cluster. Antimicrobial Agents and Chemotherapy, 40(8), 1938-1940. https://doi.org/10.1128/AAC.40.8.1938
Aarestrup, F. M., Bager, F., Jensen, N. E., Madsen, M., Meyling, A., & Wegener, H. C. (1998). Resistance to antimicrobial agents used for animal therapy in pathogenic-, zoonotic- and indicator bacteria isolated from different food animals in Denmark: A baseline study for the Danish Integrated Antimicrobial Resistance Monitoring Programme (DANMAP). APMIS, 106(7-12), 745-770. https://doi.org/10.1111/j.1699-0463.1998.tb00222.x
Aarestrup, F. M., Jensen, V. F., Emborg, H.-D., Jacobsen, E., & Wegener, H. C. (2010). Changes in the use of antimicrobials and the effects on productivity of swine farms in Denmark. American Journal of Veterinary Research, 71(7), 726-733. https://doi.org/10.2460/ajvr.71.7.726
Abraham, S., Sahibzada, S., Hewson, K., Laird, T., Abraham, R., Pavic, A., … Jordan, D. (2020). Emergence of fluoroquinolone-resistant Campylobacter jejuni and Campylobacter coli among Australian chickens in the absence of fluoroquinolone use. Applied and Environmental Microbiology, 86(8), e02765-19. https://doi.org/10.1128/AEM.02765-19
Acar, J., Casewell, M., Freeman, J., Friis, C., & Goossens, H. (2000). Avoparcin and virginiamycin as animal growth promoters: A plea for science in decision-making. Clinical Microbiology and Infection, 6(9), 477-482. https://doi.org/10.1046/j.1469-0691.2000.00128.x
Albarellos, G. A., & Landoni, M. F. (2009). Current concepts on the use of antimicrobials in cats. The Veterinary Journal, 180(3), 304-316. https://doi.org/10.1016/j.tvjl.2008.01.001
Aliabadi, F. S., Landoni, M. F., & Lees, P. (2003). Pharmacokinetics (PK), Pharmacodynamics (PD), and PK-PD integration of danofloxacin in sheep biological fluids. Antimicrobial Agents and Chemotherapy, 47(2), 626-635. https://doi.org/10.1128/AAC.47.2.626-635.2003
Aliabadi, F. S., & Lees, P. (2001). Pharmacokinetics and pharmacodynamics of danofloxacin in serum and tissue fluids of goats following intravenous and intramuscular administration. American Journal of Veterinary Research, 62(12), 1979-1989.
Aliabadi, F. S., & Lees, P. (2002). Pharmacokinetics and pharmacokinetic/pharmacodynamic integration of marbofloxacin in calf serum, exudate and transudate. Journal of Veterinary Pharmacology and Therapeutics, 25(3), 161-174.
Allott, A. J. (1937). The treatment of bovine mastitis with sulfanilamide. Journal of the American Veterinary Medical Associationavma, 91, 588-596.
Anadón, A., & Martı́nez-Larrañaga, M. R.(1999). Residues of antimicrobial drugs and feed additives in animal products: Regulatory aspects. Livestock Production Science, 59(2-3), 183-198. https://doi.org/10.1016/S0301-6226(99)00026-3
Anadón, A., Martínez-Larrañaga, M. R., Díaz, M. J., Bringas, P., Martínez, M. A., Fernàndez-Cruz, M. L., … Fernández, R. (1995). Pharmacokinetics and residues of enrofloxacin in chickens. American Journal of Veterinary Research, 56(4), 501-506.
Anderson, E. S., & Datta, N. (1965). Resistance to penicillins and its transfer in enterobacteriaceae. Lancet (London, England), 1(7382), 407-409. https://doi.org/10.1016/s0140-6736(65)90004-8
Anderson, E. S., & Lewis, M. J. (1965). Characterization of a transfer factor associated with drug resistance in Salmonella typhimurium. Nature, 208(5013), 843-849. https://doi.org/10.1038/208843a0
Anonymous (1994). Commission Regulation (EC) No 1430/94 amending annexes I, II, III and IV of Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin (OJ L 156, 23.6.1994, p. 6). Official Journal of the European Communities, L156(23/6).
Anonymous (1998). The microbial threat: The Copenhagen recommendation. Microbial Ecology in Health and Disease, 10(2), 65-67. https://doi.org/10.1080/089106098435278
Anonymous (2005). European Commission-PRESS RELEASES - Press release-Ban on antibiotics as growth promoters in animal feed enters into effect. Retrieved from http://europa.eu/rapid/press-release_IP-05-1687_en.htm
Anonymous (2008). One health: A new professional imperative. American Veterinary Medical Association. Retrieved from https://www.avma.org/KB/Resources/Reports/Documents/onehealth_final.pdf
Anonymous (2009). Reflection paper on the use of third and fourth generation cephalosporins in food producing animals in the European Union: Development of resistance and impact on human and animal health. Journal of Veterinary Pharmacology and Therapeutics, 32, 515-533. https://doi.org/10.1111/j.1365-2885.2009.01075.x
Anonymous (2013). European Union - EEAS (European External Action Service) | One Health: Addressing health risks at the interface between animals, humans and their environments. Retrieved from https://web.archive.org/web/20130715001808/http://eeas.europa.eu/health/pandemic_readiness/index_en.htm
Anonymous (2015). ECDC/EFSA/EMA first joint report on the integrated analysis of the consumption of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from humans and food-producing animals. European Centre for Disease Prevention and Control. Retrieved from https://www.ecdc.europa.eu/en/publications-data/ecdcefsaema-first-joint-report-integrated-analysis-consumption-antimicrobial
Anonymous (2016a). Guideline for the demonstration of efficacy for veterinary medicinal products containing antimicrobial substances. EMA/CVMP/627/2001-Rev.1. https://www.ema.europa.eu/en/documents/scientific-guideline/final-guideline-demonstration-efficacy-veterinary-medicinal-products-containing-antimicrobial_en.pdf
Anonymous (2016b). Updated advice on the use of colistin products in animals within the European Union: Development of resistance and possible impact on human and animal health. EMA/CVMP/CHMP/231573/2016. Retrieved from https://www.ema.europa.eu/en/documents/scientific-guideline/updated-advice-use-colistin-products-animals-within-european-union-development-resistance-possible_en-0.pdf
Anonymous (2017). EMA and EFSA Joint Scientific Opinion, RONAFA. Retrieved from https://www.efsa.europa.eu/en/efsajournal/pub/4666
Anonymous (2018a). Advice on impacts of using antimicrobials in animals [Text]. European Medicines Agency. Retrieved from https://www.ema.europa.eu/en/veterinary-regulatory/overview/antimicrobial-resistance/advice-impacts-using-antimicrobials-animals
Anonymous (2018b). Analysis of antimicrobial consumption and resistance (“JIACRA” reports) [Text]. European Medicines Agency. Retrieved from https://www.ema.europa.eu/en/veterinary-regulatory/overview/antimicrobial-resistance/analysis-antimicrobial-consumption-resistance-jiacra-reports
Anonymous (2018c). CVMP strategy on antimicrobials 2016-2020. European Medicines Agency. Retrieved from https://www.ema.europa.eu/en/veterinary-regulatory/overview/antimicrobial-resistance/cvmp-strategy-antimicrobials-2016-2020
Anonymous (2018d). European Surveillance of Veterinary Antimicrobial Consumption (ESVAC) [Text]. European Medicines Agency. Retrieved from https://www.ema.europa.eu/en/veterinary-regulatory/overview/antimicrobial-resistance/european-surveillance-veterinary-antimicrobial-consumption-esvac
Anonymous (2018e). WHO | WHO list of critically important antimicrobials (WHO CIA list) 6th edition. WHO. Retrieved from http://www.who.int/foodsafety/areas_work/antimicrobial-resistance/cia/en/
Anonymous (2019a). Answer to the request from the European Commission for updating the scientific advice on the impact on public 7 health and animal health of the use of antibiotics in animals-Categorisation of antimicrobials. EMA/CVMP/CHMP/682198/2017. Retrieved from https://www.ema.europa.eu/en/documents/other/answer-request-european-commission-updating-scientific-advice-impact-public-health-animal-health-use_en.pdf
Anonymous (2019b). CVM GFI #144 (VICH GL27) Pre-approval information for registration of new veterinary medicinal products for food-producing animals with respect to antimicrobial resistance. U.S. Food and Drug Administration. Retrieved from http://www.fda.gov/regulatory-information/search-fda-guidance-documents/cvm-gfi-144-vich-gl27-pre-approval-information-registration-new-veterinary-medicinal-products-food
Anonymous (2019c). CVM GFI #209 the judicious use of medically important antimicrobial drugs in food-producing animals. U.S. Food and Drug Administration. Retrieved from http://www.fda.gov/regulatory-information/search-fda-guidance-documents/cvm-gfi-209-judicious-use-medically-important-antimicrobial-drugs-food-producing-animals
Anonymous (2019d). FDA announces implementation of GFI #213, outlines continuing efforts to address antimicrobial resistance. FDA. Retrieved from http://www.fda.gov/animal-veterinary/cvm-updates/fda-announces-implementation-gfi-213-outlines-continuing-efforts-address-antimicrobial-resistance
Anonymous (2019e). Gelmo, Paul Josef Jakob | Encyclopedia.com. Complete Dictionary of Scientific Biography. Retrieved from https://www.encyclopedia.com/science/dictionaries-thesauruses-pictures-and-press-releases/gelmo-paul-josef-jakob
Anonymous (2019f). The National Antimicrobial Resistance Monitoring System | FDA. US FDA. Retrieved from https://www.fda.gov/animal-veterinary/antimicrobial-resistance/national-antimicrobial-resistance-monitoring-system
Anonymous (2019g). Antimicrobial Resistance | CODEXALIMENTARIUS FAO-WHO. Retrieved from http://www.fao.org/fao-who-codexalimentarius/thematic-areas/antimicrobial-resistance/en/?page=3&ipp=3&no_cache=1&tx_dynalist_pi1[par]=YToxOntzOjE6IkwiO3M6MToiMCI7fQ==
Anonymous (2019h). WHO | Optimal use of antimicrobial medicines in human and animal health. Retrieved from http://www.who.int/antimicrobial-resistance/publications/optimal-use/en/
Anonymous (2019i). WHO | Global action plan on AMR. Retrieved from http://www.who.int/antimicrobial-resistance/global-action-plan/en/
Arnold, S., Gassner, B., Giger, T., & Zwahlen, R. (2004). Banning antimicrobial growth promoters in feedstuffs does not result in increased therapeutic use of antibiotics in medicated feed in pig farming. Pharmacoepidemiology and Drug Safety, 13(5), 323-331. https://doi.org/10.1002/pds.874
Arsic, B., Barber, J., Čikoš, A., Mladenovic, M., Stankovic, N., & Novak, P. (2018). 16-membered macrolide antibiotics: A review. International Journal of Antimicrobial Agents, 51(3), 283-298. https://doi.org/10.1016/j.ijantimicag.2017.05.020
Bager, F., Madsen, M., Christensen, J., & Aarestrup, F. M. (1997). Avoparcin used as a growth promoter is associated with the occurrence of vancomycin-resistant Enterococcus faecium on Danish poultry and pig farms. Preventive Veterinary Medicine, 31(1-2), 95-112.
Baggot, J. D. (1977). Principles of drug disposition in domestic animals the basis of veterinary clinical pharmacology. Philadelphia, London, Toronto: Saunders.
Baggot, J. D. (1980). Distribution of antimicrobial agents in normal and diseased animals. Journal of the American Veterinary Medical Association, 176(10 Spec, No), 1085-1090.
Baggot, J. D., & Davis, L. E. (1973). Species differences in plasma protein binding of morphine and codeine. American Journal of Veterinary Research, 34(4), 571-574.
Baggot, J. D., Davis, L. E., & Neff, C. A. (1972). Extent of plasma protein binding of amphetamine in different species. Biochemical Pharmacology, 21(13), 1813-1816. https://doi.org/10.1016/0006-2952(72)90177-3
Baptiste, K. E., & Kyvsgaard, N. C. (2017). Do antimicrobial mass medications work? A systematic review and meta-analysis of randomised clinical trials investigating antimicrobial prophylaxis or metaphylaxis against naturally occurring bovine respiratory disease. Pathogens and. Disease, 75(7), 1-12. https://doi.org/10.1093/femspd/ftx083
Barkema, H. W., von Keyserlingk, M. A. G., Kastelic, J. P., Lam, T. J. G. M., Luby, C., Roy, J.-P., … Kelton, D. F. (2015). Invited review: Changes in the dairy industry affecting dairy cattle health and welfare. Journal of Dairy Science, 98(11), 7426-7445. https://doi.org/10.3168/jds.2015-9377
Barton, M. D. (2000). Antibiotic use in animal feed and its impact on human healt. Nutrition Research Reviews, 13(2), 279-299. https://doi.org/10.1079/095442200108729106
Bednorz, C., Oelgeschläger, K., Kinnemann, B., Hartmann, S., Neumann, K., Pieper, R., … Guenther, S. (2013). The broader context of antibiotic resistance: Zinc feed supplementation of piglets increases the proportion of multi-resistant Escherichia coli in vivo. International Journal of Medical Microbiology, 303(6-7), 396-403. https://doi.org/10.1016/j.ijmm.2013.06.004
Berendsen, B., Stolker, L., de Jong, J., Nielen, M., Tserendorj, E., Sodnomdarjaa, R., … Elliott, C. (2010). Evidence of natural occurrence of the banned antibiotic chloramphenicol in herbs and grass. Analytical and Bioanalytical Chemistry, 397(5), 1955-1963. https://doi.org/10.1007/s00216-010-3724-6
Bion, C., Beck Henzelin, A., Qu, Y., Pizzocri, G., Bolzoni, G., & Buffoli, E. (2015). Analysis of 27 antibiotic residues in raw cow’s milk and milk-based products - Validation of Delvotest® T. Food Additives & Contaminants: Part A, 33, 1-6. https://doi.org/10.1080/19440049.2015.1104731
Boisseau, J. (1993). Basis for the evaluation of the microbiological risks due to veterinary drug residues in food. Veterinary Microbiology, 35(3-4), 187-192.
Bon, C., Toutain, P. L., Concordet, D., Gehring, R., Martin-Jimenez, T., Smith, J., … Mochel, J. P. (2018). Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed-effects to characterize and quantify variability in drug pharmacokinetics. Journal of Veterinary Pharmacology and Therapeutics, 41(2), 171-183. https://doi.org/10.1111/jvp.12473
Boobis, A., Cerniglia, C., Chicoine, A., Fattori, V., Lipp, M., Reuss, R., … Tritscher, A. (2017). Characterizing chronic and acute health risks of residues of veterinary drugs in food: Latest methodological developments by the joint FAO/WHO expert committee on food additives. Critical Reviews in Toxicology, 47(10), 885-899. https://doi.org/10.1080/10408444.2017.1340259
Bousquet-Mélou, A. (2018). Precision medicine for the prudent use of veterinary antimicrobials in food producing animals. Journal of Veterinary Pharmacology and Therapeutics, 41(Suppl), 25-27. https://doi.org/10.1111/jvp.12624
Boxall, A. B. A., Johnson, P., Smith, E. J., Sinclair, C. J., Stutt, E., & Levy, L. S. (2006). Uptake of veterinary medicines from soils into plants. Journal of Agricultural and Food Chemistry, 54(6), 2288-2297. https://doi.org/10.1021/jf053041t
Brenes, A., & Roura, E. (2010). Essential oils in poultry nutrition: Main effects and modes of action. Animal Feed Science and Technology, 158(1-2), 1-14. https://doi.org/10.1016/j.anifeedsci.2010.03.007
Brown, S. A., & Riviere, J. E. (1991). Comparative pharmacokinetics of aminoglycoside antibiotics. Journal of Veterinary Pharmacology and Therapeutics, 14(1), 1-35.
Brunton, L. A., Duncan, D., Coldham, N. G., Snow, L. C., & Jones, J. R. (2012). A survey of antimicrobial usage on dairy farms and waste milk feeding practices in England and Wales. The Veterinary Record, 171(12), 296. https://doi.org/10.1136/vr.100924
Bywater, R. J. (2004). Veterinary use of antimicrobials and emergence of resistance in zoonotic and sentinel bacteria in the EU. Journal of Veterinary Medicine Series B, 51(8-9), 361-363. https://doi.org/10.1111/j.1439-0450.2004.00791.x
Cabello, F. C. (2006). Heavy use of prophylactic antibiotics in aquaculture: A growing problem for human and animal health and for the environment. Environmental Microbiology, 8(7), 1137-1144. https://doi.org/10.1111/j.1462-2920.2006.01054.x
Cagnardi, P., Di Cesare, F., Toutain, P.-L., Bousquet-Mélou, A., Ravasio, G., & Villa, R. (2018). Population pharmacokinetic study of cefazolin used prophylactically in canine surgery for susceptibility testing breakpoint determination. Frontiers in Pharmacology, 9, 1137. https://doi.org/10.3389/fphar.2018.01137
Campbell, W. C. (2008). History of the discovery of sulfaquinoxaline as a coccidiostat. The Journal of Parasitology, 94(4), 934-945. https://doi.org/10.1645/GE-1413.1
Casewell, M., Friis, C., Marco, E., McMullin, P., & Phillips, I. (2003). The European ban on growth-promoting antibiotics and emerging consequences for human and animal health. The Journal of Antimicrobial Chemotherapy, 52(2), 159-161. https://doi.org/10.1093/jac/dkg313
Castanon, J. I. R. (2007). History of the use of antibiotic as growth promoters in European poultry feeds. Poultry Science, 86(11), 2466-2471. https://doi.org/10.3382/ps.2007-00249
Catry, B., Cavaleri, M., Baptiste, K., Grave, K., Grein, K., Holm, A., … Edo, J. T. (2015). Use of colistin-containing products within the European Union and European Economic Area (EU/EEA): Development of resistance in animals and possible impact on human and animal health. International Journal of Antimicrobial Agents, 46(3), 297-306. https://doi.org/10.1016/j.ijantimicag.2015.06.005
Catry, B., Van Duijkeren, E., Pomba, M. C., Greko, C., Moreno, M. A., Pyörälä, S., … Torren-Edo, J. (2010). Reflection paper on MRSA in food-producing and companion animals: Epidemiology and control options for human and animal health. Epidemiology and Infection, 138(05), 626. https://doi.org/10.1017/S0950268810000014
Cerniglia, C. E., & Kotarski, S. (2005). Approaches in the safety evaluations of veterinary antimicrobial agents in food to determine the effects on the human intestinal microflora. Journal of Veterinary Pharmacology and Therapeutics, 28(1), 3-20. https://doi.org/10.1111/j.1365-2885.2004.00595.x
Cerniglia, C. E., Pineiro, S. A., & Kotarski, S. F. (2016). An update discussion on the current assessment of the safety of veterinary antimicrobial drug residues in food with regard to their impact on the human intestinal microbiome: Assessing antimicrobial drug residue effects on the human intestinal microbiota. Drug Testing and Analysis, 8(5-6), 539-548. https://doi.org/10.1002/dta.2024
Chait, R., Craney, A., & Kishony, R. (2007). Antibiotic interactions that select against resistance. Nature, 446(7136), 668-671. https://doi.org/10.1038/nature05685
Chantziaras, I., Boyen, F., Callens, B., & Dewulf, J. (2014). Correlation between veterinary antimicrobial use and antimicrobial resistance in food-producing animals: A report on seven countries. Journal of Antimicrobial Chemotherapy, 69(3), 827-834. https://doi.org/10.1093/jac/dkt443
Chapman, H. D., Jeffers, T. K., & Williams, R. B. (2010). Forty years of monensin for the control of coccidiosis in poultry. Poultry Science, 89(9), 1788-1801. https://doi.org/10.3382/ps.2010-00931
Chattopadhyay, M. K. (2014). Use of antibiotics as feed additives: A burning question. Frontiers in Microbiology, 5, 1-3. https://doi.org/10.3389/fmicb.2014.00334
Cheng, A. C., Turnidge, J., Collignon, P., Looke, D., Barton, M., & Gottlieb, T. (2012). Control of fluoroquinolone resistance through successful regulation, Australia. Emerging Infectious Diseases, 18(9), 1453-1460. https://doi.org/10.3201/eid1809.111515
Collignon, P., Aarestrup, F. M., Irwin, R., & McEwen, S. (2013). Human deaths and third-generation cephalosporin use in poultry, Europe. Emerging Infectious Diseases, 19(8), 1339-1340. https://doi.org/10.3201/eid.1908.120681
Collineau, L., Boerlin, P., Carson, C. A., Chapman, B., Fazil, A., Hetman, B., … Smith, B. A. (2019). Integrating whole-genome sequencing data into quantitative risk assessment of foodborne antimicrobial resistance: A review of opportunities and challenges. Frontiers in Microbiology, 10, 1107. https://doi.org/10.3389/fmicb.2019.01107
Constable, P. D., & Morin, D. E. (2003). Treatment of clinical mastitis. Using antimicrobial susceptibility profiles for treatment decisions. The Veterinary Clinics of North America. Food Animal Practice, 19(1), 139-155.
Corpet, D. E. (1993). An evaluation of methods to assess the effect of antimicrobial residues on the human gut flora. Veterinary Microbiology, 35(3-4), 199-212.
Das, I., Fraise, A., & Wise, R. (1997). Are glycopeptide-resistant enterococci in animals a threat to human beings? The Lancet, 349(9057), 997-998. https://doi.org/10.1016/S0140-6736(05)62894-2
Davis, L. E., Neff, C. A., Baggot, J. D., & Powers, T. E. (1972). Pharmacokinetics of chloramphenicol in domesticated animals. American Journal of Veterinary Research, 33(11), 2259-2266.
Dayan, A. D. (1993). Allergy to antimicrobial residues in food: Assessment of the risk to man. Veterinary Microbiology, 35(3-4), 213-226.
de Jong, A., Thomas, V., Klein, U., Marion, H., Moyaert, H., Simjee, S., & Vallé, M. (2013). Pan-European resistance monitoring programmes encompassing food-borne bacteria and target pathogens of food-producing and companion animals. International Journal of Antimicrobial Agents, 41(5), 403-409. https://doi.org/10.1016/j.ijantimicag.2012.11.004
Deatherage, F. E. (1957). Use of antibiotics in the preservation of meats and other food products. American Journal of Public Health and the Nation’s Health, 47(5), 594-600.
Dierikx, C. M., van Duijkeren, E., Schoormans, A. H. W., van Essen-Zandbergen, A., Veldman, K., Kant, A., … Mevius, D. J. (2012). Occurrence and characteristics of extended-spectrum-β-lactamase- and AmpC-producing clinical isolates derived from companion animals and horses. Journal of Antimicrobial Chemotherapy, 67(6), 1368-1374. https://doi.org/10.1093/jac/dks049
Dodd, F. H., Westgarth, D. R., Neave, F. K., & Kingwill, R. G. (1969). Mastitis-The strategy of control. Journal of Dairy Science, 52(5), 689-695. https://doi.org/10.3168/jds.S0022-0302(69)86631-2
Domalaon, R., Okunnu, O., Zhanel, G. G., & Schweizer, F. (2019). Synergistic combinations of anthelmintic salicylanilides oxyclozanide, rafoxanide, and closantel with colistin eradicates multidrug-resistant colistin-resistant Gram-negative bacilli. The Journal of Antibiotics, 72(8), 605-616. https://doi.org/10.1038/s41429-019-0186-8
Dorado-García, A., Smid, J. H., van Pelt, W., Bonten, M. J. M., Fluit, A. C., van den Bunt, G., Wagenaar, J. A., Hordijk, J., Dierikx, C. M., Veldman, K. T., de Koeijer, A., Dohmen, W., Schmitt, H., Liakopoulos, A., Pacholewicz, E., Lam, T. J. G. M., Velthuis, A. G., Heuvelink, A., Gonggrijp, M. A., … Heederik, D. J. J. (2018). Molecular relatedness of ESBL/AmpC-producing Escherichia coli from humans, animals, food and the environment: A pooled analysis. Journal of Antimicrobial Chemotherapy, 73(2), 339-347. https://doi.org/10.1093/jac/dkx397
Drouillard, J. S. (2018). Current situation and future trends for beef production in the United States of America-A review. Asian-Australasian Journal of Animal Sciences, 31(7), 1007-1016. https://doi.org/10.5713/ajas.18.0428
Duse, A., Waller, K. P., Emanuelson, U., Unnerstad, H. E., Persson, Y., & Bengtsson, B. (2013). Farming practices in Sweden related to feeding milk and colostrum from cows treated with antimicrobials to dairy calves. Acta Veterinaria Scandinavica, 55, 49. https://doi.org/10.1186/1751-0147-55-49
Dutil, L., Irwin, R., Finley, R., Ng, L. K., Avery, B., Boerlin, P., … Pillai, D. R. (2010). Ceftiofur resistance in Salmonella enterica Serovar Heidelberg from chicken meat and humans, Canada. Emerging Infectious Diseases, 16(1), 48-54. https://doi.org/10.3201/eid1601.090729
El Garch, F., de Jong, A., Simjee, S., Moyaert, H., Klein, U., Ludwig, C., … Siegwart, E. (2016). Monitoring of antimicrobial susceptibility of respiratory tract pathogens isolated from diseased cattle and pigs across Europe, 2009-2012: VetPath results. Veterinary Microbiology, 194, 11-22. https://doi.org/10.1016/j.vetmic.2016.04.009
Endtz, H. P., Mouton, R. P., van der Reyden, T., Ruijs, G. J., Biever, M., & van Klingeren, B. (1990). Fluoroquinolone resistance in Campylobacter spp isolated from human stools and poultry products. Lancet (London, England), 335(8692), 787. https://doi.org/10.1016/0140-6736(90)90897-e
Endtz, H. P., Ruijs, G. J., van Klingeren, B., Jansen, W. H., van der Reyden, T., & Mouton, R. P. (1991). Quinolone resistance in campylobacter isolated from man and poultry following the introduction of fluoroquinolones in veterinary medicine. The Journal of Antimicrobial Chemotherapy, 27(2), 199-208. https://doi.org/10.1093/jac/27.2.199
Engberg, J. (2001). Quinolone and Macrolide Resistance in Campylobacter jejuni and C. coli: Resistance Mechanisms and Trends in Human Isolates. Emerging Infectious Diseases, 7(1), 24-34. https://doi.org/10.3201/eid0701.010104
Erskine, R. J., Tyler, J. W., Riddell, M. G., & Wilson, R. C. (1991). Theory, use, and realities of efficacy and food safety of antimicrobial treatment of acute coliform mastitis. Journal of the American Veterinary Medical Association, 198(6), 980-984.
Evans, N. A. (2005). Tulathromycin: An overview of a new triamilide antibiotic for livestock respiratory disease. Veterinary Therapeutics: Research in Applied Veterinary Medicine, 6(2), 83-95.
Faustini, R., & Vaghi, M. A. (1962a). Blood levels of sulfamethoxy-pyridazine, sulfapyrazinemethoxyne, and sulfamethazine in swine. American Journal of Veterinary Research, 23, 65-69.
Faustini, R., & Vaghi, M. A. (1962b). Some pharmacologic properties of sulfamethoxpyridazine and a new sulfonamide, sulfapyrazinemethoxyne, in calves. American Journal of Veterinary Research, 23, 58-63.
Fegan, N., & Jenson, I. (2018). The role of meat in foodborne disease: Is there a coming revolution in risk assessment and management? Meat Science, 144, 22-29. https://doi.org/10.1016/j.meatsci.2018.04.018
Ferran, A. A., Toutain, P.-L., & Bousquet-Mélou, A. (2011). Impact of early versus later fluoroquinolone treatment on the clinical; microbiological and resistance outcomes in a mouse-lung model of Pasteurella multocida infection. Veterinary Microbiology, 148(2-4), 292-297. https://doi.org/10.1016/j.vetmic.2010.09.005
Fischbach, M. A. (2011). Combination therapies for combating antimicrobial resistance. Current Opinion in Microbiology, 14(5), 519-523. https://doi.org/10.1016/j.mib.2011.08.003
Food and Agriculture Organization of the United Nations & World Health Organization (Eds.) (2009). Principles and methods for the risk assessment of chemicals in food. Geneva, Switzerland: World Health Organization.
Francis, J. (1947). Bacterial chemotherapy in veterinary medicine. The Veterinary Record, 59(10), 131-137.
Francis, M. E., Marshall, A. B., & Turner, W. T. (1978). Amoxycillin: Clinical trials in dogs and cats. The Veterinary Record, 102(17), 377-380.
Franklin, A., Acar, J., Anthony, F., Gupta, R., Nicholls, T., Tamura, Y., … Costarrica, M. L., & Office International des Epizooties Ad hoc Group (2001). Antimicrobial resistance: Harmonisation of national antimicrobial resistance monitoring and surveillance programmes in animals and in animal-derived food. Revue Scientifique Et Technique (International Office of Epizootics), 20(3), 859-870. https://doi.org/10.20506/rst.20.3.1315
Franz, C., Baser, K., & Windisch, W. (2010). Essential oils and aromatic plants in animal feeding-A European perspective. A Review. Flavour and Fragrance Journal, 25(5), 327-340. https://doi.org/10.1002/ffj.1967
Frimodt-Møller, N. (2004). Microbial Threat-The Copenhagen Recommendations initiative of the EU. Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health, 51(8-9), 400-402. https://doi.org/10.1111/j.1439-0450.2004.00786.x
Gadde, U., Kim, W. H., Oh, S. T., & Lillehoj, H. S. (2017). Alternatives to antibiotics for maximizing growth performance and feed efficiency in poultry: A review. Animal Health Research Reviews, 18(1), 26-45. https://doi.org/10.1017/S1466252316000207
Gaggìa, F., Mattarelli, P., & Biavati, B. (2010). Probiotics and prebiotics in animal feeding for safe food production. International Journal of Food Microbiology, 141, S15-S28. https://doi.org/10.1016/j.ijfoodmicro.2010.02.031
Gaugain-Juhel, M., Delépine, B., Gautier, S., Fourmond, M. P., Gaudin, V., Hurtaud-Pessel, D., … Sanders, P. (2009). Validation of a liquid chromatography-tandem mass spectrometry screening method to monitor 58 antibiotics in milk: A qualitative approach. Food Additives & Contaminants: Part A, 26(11), 1459-1471. https://doi.org/10.1080/02652030903150575
Gehring, R., Haskell, S. R., Payne, M. A., Craigmill, A. L., Webb, A. I., & Riviere, J. E. (2005). Aminoglycoside residues in food of animal origin. Journal of the American Veterinary Medical Association, 227(1), 63-66.
Gehring, R., & Smith, G. W. (2006). An overview of factors affecting the disposition of intramammary preparations used to treat bovine mastitis. Journal of Veterinary Pharmacology and Therapeutics, 29(4), 237-241. https://doi.org/10.1111/j.1365-2885.2006.00750.x
Gelband, H., & Laxminarayan, R. (2015). Tackling antimicrobial resistance at global and local scales. Trends in Microbiology, 23(9), 524-526. https://doi.org/10.1016/j.tim.2015.06.005
Gerbin, C. S. (2014). Enhancing US-Japan cooperation to combat antimicrobial resistance. Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science, 12(6), 337-345. https://doi.org/10.1089/bsp.2014.0034
Gillings, M. R., Gaze, W. H., Pruden, A., Smalla, K., Tiedje, J. M., & Zhu, Y.-G. (2015). Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution. The ISME Journal, 9(6), 1269-1279. https://doi.org/10.1038/ismej.2014.226
Graham, J. P., Boland, J. J., & Silbergeld, E. (2007). Growth promoting antibiotics in food animal production: An economic analysis. Public Health Reports (Washington, D.C.: 1974), 122(1), 79-87. https://doi.org/10.1177/003335490712200111
Grave, K., Kaldhusdal, M., Kruse, H., Harr, L. M. F., & Flatlandsmo, K. (2004). What has happened in Norway after the ban of avoparcin? Consumption of antimicrobials by poultry. Preventive Veterinary Medicine, 62(1), 59-72. https://doi.org/10.1016/j.prevetmed.2003.08.009
Graveland, H., Wagenaar, J. A., Heesterbeek, H., Mevius, D., van Duijkeren, E., & Heederik, D. (2010). Methicillin resistant Staphylococcus aureus ST398 in veal calf farming: Human MRSA carriage related with animal antimicrobial usage and farm hygiene. PLoS One, 5(6), e10990. https://doi.org/10.1371/journal.pone.0010990
Greko, C. (2003). Pharmacokinetic/pharmacodynamic relationship of danofloxacin against Mannheimia haemolytica in a tissue-cage model in calves. Journal of Antimicrobial Chemotherapy, 52(2), 253-257. https://doi.org/10.1093/jac/dkg339
Greko, C., Bengtsson, B., Franklin, A., Jacobsson, S.-O., Wiese, B., & Luthman, J. (2002). Efficacy of trimethoprim-sulfadoxine against Escherichia coli in a tissue cage model in calves. Journal of Veterinary Pharmacology and Therapeutics, 25(6), 413-423.
Greko, C., Finn, M., Ohagen, P., Franklin, A., & Bengtsson, B. (2003). A tissue cage model in calves for studies on pharmacokinetic/pharmacodynamic interactions of antimicrobials. International Journal of Antimicrobial Agents, 22(4), 429-438.
Guardabassi, L., Apley, M., Olsen, J. E., Toutain, P.-L., & Weese, S. (2018). Optimization of antimicrobial treatment to minimize resistance selection. Microbiology Spectrum, 6(3), 1-36. https://doi.org/10.1128/microbiolspec.ARBA-0018-2017
Guardabassi, L., Damborg, P., Stamm, I., Kopp, P. A., Broens, E. M., Toutain, P.-L., & ESCMID Study Group for Veterinary Microbiology (2017). Diagnostic microbiology in veterinary dermatology: Present and future. Veterinary Dermatology, 28(1), 146-157. https://doi.org/10.1111/vde.12414
Guardabassi, L., Schwarz, S., & Lloyd, D. (2004). Pet animals as reservoirs of antimicrobial-resistant bacteria: Review. Journal of Antimicrobial Chemotherapy, 54(2), 321-332. https://doi.org/10.1093/jac/dkh332
Gustafson, R. H. (1991). Use of antibiotics in livestock and human health concerns. Journal of Dairy Science, 74(4), 1428-1432. https://doi.org/10.3168/jds.S0022-0302(91)78299-4
Gustafson, R. H., & Bowen, R. E. (1997). Antibiotic use in animal agriculture. Journal of Applied Microbiology, 83(5), 531-541.
Hammerum, A. M., Heuer, O. E., Lester, C. H., Agersø, Y., Seyfarth, A. M., Emborg, H.-D., … Monnet, D. L. (2007). Comment on: Withdrawal of growth-promoting antibiotics in Europe and its effects in relation to human health. International Journal of Antimicrobial Agents, 30(5), 466-468. https://doi.org/10.1016/j.ijantimicag.2007.07.012
Hanekamp, J. C., & Calabrese, E. J. (2006). Chloramphenicol, European legislation and hormesis commentary. Dose-Response: A Publication of International Hormesis Society, 5(2), 91-93. https://doi.org/10.2203/dose-response.06-012.Hanekamp
Hao, H., Cheng, G., Iqbal, Z., Ai, X., Hussain, H. I., Huang, L., … Yuan, Z. (2014). Benefits and risks of antimicrobial use in food-producing animals. Frontiers in Microbiology, 5, 288. https://doi.org/10.3389/fmicb.2014.00288
Hao, H., Sander, P., Iqbal, Z., Wang, Y., Cheng, G., & Yuan, Z. (2016). The risk of some veterinary antimicrobial agents on public health associated with antimicrobial resistance and their molecular basis. Frontiers in Microbiology, 7, 1-11. https://doi.org/10.3389/fmicb.2016.01626
Hasman, H., Mevius, D., Veldman, K., Olesen, I., & Aarestrup, F. M. (2005). β-Lactamases among extended-spectrum β-lactamase (ESBL)-resistant Salmonella from poultry, poultry products and human patients in The Netherlands. Journal of Antimicrobial Chemotherapy, 56(1), 115-121. https://doi.org/10.1093/jac/dki190
Helke, K. L., McCrackin, M. A., Galloway, A. M., Poole, A. Z., Salgado, C. D., & Marriott, B. P. (2017). Effects of antimicrobial use in agricultural animals on drug-resistant foodborne salmonellosis in humans: A systematic literature review. Critical Reviews in Food Science and Nutrition, 57(3), 472-488. https://doi.org/10.1080/10408398.2016.1230088
Hendriksen, R. S., Mevius, D. J., Schroeter, A., Teale, C., Jouy, E., Butaye, P., … Aarestrup, F. M. (2008). Occurrence of antimicrobial resistance among bacterial pathogens and indicator bacteria in pigs in different European countries from year 2002-2004: The ARBAO-II study. Acta Veterinaria Scandinavica, 50(1), 19. https://doi.org/10.1186/1751-0147-50-19
Hendriksen, R. S., Mevius, D. J., Schroeter, A., Teale, C., Meunier, D., Butaye, P., … Aarestrup, F. M. (2008). Prevalence of antimicrobial resistance among bacterial pathogens isolated from cattle in different European countries: 2002-2004. Acta Veterinaria Scandinavica, 50(1), 28. https://doi.org/10.1186/1751-0147-50-28
Henri, J., Carrez, R., Méda, B., Laurentie, M., & Sanders, P. (2017). A physiologically based pharmacokinetic model for chickens exposed to feed supplemented with monensin during their lifetime. Journal of Veterinary Pharmacology and Therapeutics, 40(4), 370-382. https://doi.org/10.1111/jvp.12370
Heuer, H., Schmitt, H., & Smalla, K. (2011). Antibiotic resistance gene spread due to manure application on agricultural fields. Current Opinion in Microbiology, 14(3), 236-243. https://doi.org/10.1016/j.mib.2011.04.009
Hillier, A., Lloyd, D. H., Weese, J. S., Blondeau, J. M., Boothe, D., Breitschwerdt, E., … Sykes, J. E. (2014). Guidelines for the diagnosis and antimicrobial therapy of canine superficial bacterial folliculitis (Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases). Veterinary Dermatology, 25(3), 163-e43. https://doi.org/10.1111/vde.12118
Hojberg, O., Canibe, N., Poulsen, H. D., Hedemann, M. S., & Jensen, B. B. (2005). Influence of dietary zinc oxide and copper sulfate on the gastrointestinal ecosystem in newly weaned piglets. Applied and Environmental Microbiology, 71(5), 2267-2277. https://doi.org/10.1128/AEM.71.5.2267-2277.2005
Holmberg, S. D., Osterholm, M. T., Senger, K. A., & Cohen, M. L. (1984). Drug-resistant salmonella from animals fed antimicrobials. New England Journal of Medicine, 311(10), 617-622. https://doi.org/10.1056/NEJM198409063111001
Hölzel, C. S., Müller, C., Harms, K. S., Mikolajewski, S., Schäfer, S., Schwaiger, K., & Bauer, J. (2012). Heavy metals in liquid pig manure in light of bacterial antimicrobial resistance. Environmental Research, 113, 21-27. https://doi.org/10.1016/j.envres.2012.01.002
Huang, R. A., Letendre, L. T., Banav, N., Fischer, J., & Somerville, B. (2009). Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity: Pharmacokinetics of gamithromycin in cattle. Journal of Veterinary Pharmacology and Therapeutics, 33(3), 227-237. https://doi.org/10.1111/j.1365-2885.2009.01125.x
Huber, W. G. (1965). The chemotherapy of bacterial infections. In L. M. Jones (Ed.), Veterinary pharmacology and therapeutics (3rd ed., pp. 551-592). Ames, IA: Iowa State University Press.
Hummel, A. S., Hertel, C., Holzapfel, W. H., & Franz, C. M. A. P. (2007). Antibiotic resistances of starter and probiotic strains of lactic acid bacteria. Applied and Environmental Microbiology, 73(3), 730-739. https://doi.org/10.1128/AEM.02105-06
Hummel, R., Tschäpe, H., & Witte, W. (1986). Spread of plasmid-mediated nourseothricin resistance due to antibiotic use in animal husbandry. Journal of Basic Microbiology, 26(8), 461-466.
Humphrey, T. J., Jørgensen, F., Frost, J. A., Wadda, H., Domingue, G., Elviss, N. C., … Piddock, L. J. V. (2005). Prevalence and subtypes of ciprofloxacin-resistant Campylobacter spp. In commercial poultry flocks before, during, and after treatment with fluoroquinolones. Antimicrobial Agents and Chemotherapy, 49(2), 690-698. https://doi.org/10.1128/AAC.49.2.690-698.2005
Huyghebaert, G., Ducatelle, R., & Immerseel, F. V. (2011). An update on alternatives to antimicrobial growth promoters for broilers. The Veterinary Journal, 187(2), 182-188. https://doi.org/10.1016/j.tvjl.2010.03.003
Jackson, K. S., Carstens, G. E., Tedeschi, L. O., & Pinchak, W. E. (2016). Changes in feeding behavior patterns and dry matter intake before clinical symptoms associated with bovine respiratory disease in growing bulls. Journal of Animal Science, 94(4), 1644-1652. https://doi.org/10.2527/jas.2015-9993
Jacobs, J. A., & Siegford, J. M. (2012). Invited review: The impact of automatic milking systems on dairy cow management, behavior, health, and welfare. Journal of Dairy Science, 95(5), 2227-2247. https://doi.org/10.3168/jds.2011-4943
Jensen, H. H., & Hayes, D. J. (2014). Impact of Denmark’s ban on antimicrobials for growth promotion. Current Opinion in Microbiology, 19, 30-36. https://doi.org/10.1016/j.mib.2014.05.020
Jensen, U. S., Muller, A., Brandt, C. T., Frimodt-Møller, N., Hammerum, A. M., Monnet, D. L., & DANRES study group (2010). Effect of generics on price and consumption of ciprofloxacin in primary healthcare: The relationship to increasing resistance. The Journal of Antimicrobial Chemotherapy, 65(6), 1286-1291. https://doi.org/10.1093/jac/dkq093
Jones, F. T., & Ricke, S. C. (2003). Observations on the history of the development of antimicrobials and their use in poultry feeds. Poultry Science, 82(4), 613-617. https://doi.org/10.1093/ps/82.4.613
Jones, L. M. (1946). Some aspects of the pharmacology of the sulfonamides and penicillin. The North American Veterinarian, 27(7), 422-425.
Juhász-Kaszanyitzky, É., Jánosi, S., Somogyi, P., Dán, Á., van Bloois, L. G., van Duijkeren, E., & Wagenaar, J. A.(2007). MRSA transmission between cows and humans. Emerging Infectious Diseases, 13(4), 630-632. https://doi.org/10.3201/eid1304.060833
Kausche, F. M., & Robb, E. J. (2003). A comprehensive review of ceftiofur sodium and hydrochloride formulations for treatment of acute bovine foot rot. Veterinary Therapeutics: Research in Applied Veterinary Medicine, 4(1), 83-93.
Keefe, T. J. (1978). Results of a clinical study to determine frequency of dosage for amoxicillin trihydrate in cats. Veterinary Medicine, Small Animal Clinician: VM, SAC, 73(4), 447-450.
Kemper, N. (2008). Veterinary antibiotics in the aquatic and terrestrial environment. Ecological Indicators, 8(1), 1-13. https://doi.org/10.1016/j.ecolind.2007.06.002
Kempf, I., Fleury, M. A., Drider, D., Bruneau, M., Sanders, P., Chauvin, C., … Jouy, E. (2013). What do we know about resistance to colistin in Enterobacteriaceae in avian and pig production in Europe? International Journal of Antimicrobial Agents, 42(5), 379-383. https://doi.org/10.1016/j.ijantimicag.2013.06.012
Kidd, A. R. (1995). Potential risk of effects of antimicrobial residues on human gastrointestinal microflora. The Veterinary Record, 137(19), 496. https://doi.org/10.1136/vr.137.19.496-a
Kilgore, W. R., Spensley, M. S., Sun, F., Nutsch, R. G., Rooney, K. A., & Skogerboe, T. L. (2005). Therapeutic efficacy of tulathromycin, a novel triamilide antimicrobial, against bovine respiratory disease in feeder calves. Veterinary Therapeutics: Research in Applied Veterinary Medicine, 6(2), 143-153.
Kirchhelle, C. (2018a). Swann song: Antibiotic regulation in british livestock production (1953-2006). Bulletin of the History of Medicine, 92(2), 317-350. https://doi.org/10.1353/bhm.2018.0029
Kirchhelle, C. (2018b). Pharming animals: A global history of antibiotics in food production (1935-2017). Palgrave Communications, 4(1), 96. https://doi.org/10.1057/s41599-018-0152-2
Koritz, G. D., Bourne, D. W., Dittert, L. W., & Bevill, R. F. (1977). Disposition of sulfonamides in food-producing animals: Pharmacokinetics of sulfathiazole in sheep. American Journal of Veterinary Research, 38(7), 979-982.
Kroes, R., Renwick, A. G., Cheeseman, M., Kleiner, J., Mangelsdorf, I., Piersma, A., … Würtzen, G., & European branch of the International Life Sciences Institute (2004). Structure-based thresholds of toxicological concern (TTC): Guidance for application to substances present at low levels in the diet. Food and Chemical Toxicology: an International Journal Published for the British Industrial Biological Research Association, 42(1), 65-83.
Krömker, V., & Leimbach, S. (2017). Mastitis treatment-reduction in antibiotic usage in dairy cows. Reproduction in Domestic Animals, 52, 21-29. https://doi.org/10.1111/rda.13032
Lappin, M. R., Blondeau, J., Boothe, D., Breitschwerdt, E. B., Guardabassi, L., Lloyd, D. H., … Weese, J. S. (2017). Antimicrobial use guidelines for treatment of respiratory tract disease in dogs and cats: Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases. Journal of Veterinary Internal Medicine, 31(2), 279-294. https://doi.org/10.1111/jvim.14627
LeBlanc, S. J., Lissemore, K. D., Kelton, D. F., Duffield, T. F., & Leslie, K. E. (2006). Major advances in disease prevention in dairy cattle. Journal of Dairy Science, 89(4), 1267-1279. https://doi.org/10.3168/jds.S0022-0302(06)72195-6
Lederberg, J. (1952). Cell genetics and hereditary symbiosis. Physiological Reviews, 32(4), 403-430. https://doi.org/10.1152/physrev.1952.32.4.403
Lees, P. (2013). Pharmacokinetics, pharmacodynamics and therapeutics of pradofloxacin in the dog and cat. Journal of Veterinary Pharmacology and Therapeutics, 36(3), 209-221. https://doi.org/10.1111/jvp.12036
Lehmann, R. (1972). Implementation of recommendations contained in report to commissioner concerning use of antibiotics in animal feed. Journal of Animal Science, 35(6), 1340-1341.
Lekunberri, I., Subirats, J., Borrego, C. M., & Balcázar, J. L. (2017). Exploring the contribution of bacteriophages to antibiotic resistance. Environmental Pollution, 220, 981-984. https://doi.org/10.1016/j.envpol.2016.11.059
Leverstein-van Hall, M. A., Dierikx, C. M., Stuart, J. C., Voets, G. M., van den Munckhof, M. P., van Essen-Zandbergen, A., … Mevius, D. J. (2011). Dutch patients, retail chicken meat and poultry share the same ESBL genes, plasmids and strains. Clinical Microbiology and Infection, 17(6), 873-880. https://doi.org/10.1111/j.1469-0691.2011.03497.x
Levy, S. B., & Marshall, B. (2004). Antibacterial resistance worldwide: Causes, challenges and responses. Nature Medicine, 10(S12), S122-S129. https://doi.org/10.1038/nm1145
Lhermie, G., Toutain, P.-L., El Garch, F., Bousquet-Mélou, A., & Assié, S. (2017). Implementing precision antimicrobial therapy for the treatment of bovine respiratory disease: Current limitations and perspectives. Frontiers in Veterinary Science, 4, 143. https://doi.org/10.3389/fvets.2017.00143
Li, M., Gehring, R., Tell, L., Baynes, R., Huang, Q., & Riviere, J. E. (2014). Interspecies mixed-effect pharmacokinetic modeling of penicillin G in cattle and swine. Antimicrobial Agents and Chemotherapy, 58(8), 4495-4503. https://doi.org/10.1128/AAC.02806-14
Lin, Z., Gehring, R., Mochel, J. P., Lavé, T., & Riviere, J. E. (2016). Mathematical modeling and simulation in animal health - Part II: Principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment. Journal of Veterinary Pharmacology and Therapeutics, 39(5), 421-438. https://doi.org/10.1111/jvp.12311
Litster, A., Moss, S., Honnery, M., Rees, B., Edingloh, M., & Trott, D. (2007). Clinical efficacy and palatability of pradofloxacin 2.5% oral suspension for the treatment of bacterial lower urinary tract infections in cats. Journal of Veterinary Internal Medicine, 21(5), 990-995. https://doi.org/10.1111/j.1939-1676.2007.tb03054.x
Little, S. B., Crabb, H. K., Woodward, A. P., Browning, G. F., & Billman-Jacobe, H. (2019). Review: Water medication of growing pigs: sources of between-animal variability in systemic exposure to antimicrobials. Animal, 13(12), 3031-3040. https://doi.org/10.1017/S1751731119001903
Liu, Y.-Y., Wang, Y., Walsh, T. R., Yi, L.-X., Zhang, R., Spencer, J., … Shen, J. (2016). Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: A microbiological and molecular biological study. The Lancet Infectious Diseases, 16(2), 161-168. https://doi.org/10.1016/S1473-3099(15)00424-7
Lu, F. C., & Sielken, R. L. (1991). Assessment of safety/risk of chemicals: Inception and evolution of the ADI and dose-response modeling procedures. Toxicology Letters, 59(1-3), 5-40.
Ly-Chatain, M. H. (2014). The factors affecting effectiveness of treatment in phages therapy. Frontiers in Microbiology, 5, 1-7. https://doi.org/10.3389/fmicb.2014.00051
Macaulay, T. B. (1878). Critical and historical essays contributed to the Edinburgh review: Sir James Mackintosh, history of the revolution in England. London, UK: Longmans, Green, Reader and Dyer.
Manten, A. (1963). The non-medical use of antibiotics and the risk of causing microbial drug-resistance. Bulletin of the World Health Organization, 29, 387-400.
Marshall, B. M., & Levy, S. B. (2011). Food animals and antimicrobials: Impacts on human health. Clinical Microbiology Reviews, 24(4), 718-733. https://doi.org/10.1128/CMR.00002-11
Martinez, M. N. (2011). Factors influencing the use and interpretation of animal models in the development of parenteral drug delivery systems. The AAPS Journal, 13(4), 632-649. https://doi.org/10.1208/s12248-011-9303-8
Martinez, M. N., Lindquist, D., & Modric, S. (2010). Terminology challenges: Defining modified release dosage forms in veterinary medicine. Journal of Pharmaceutical Sciences, 99(8), 3281-3290. https://doi.org/10.1002/jps.22095
Martinez, M., & Modric, S. (2010). Patient variation in veterinary medicine: Part I. Influence of altered physiological states. Journal of Veterinary Pharmacology and Therapeutics, 33(3), 213-226. https://doi.org/10.1111/j.1365-2885.2009.01139.x
Martinez, M. N., Watts, J. L., & Gilbert, J. M. (2019). Questions associated with the development of novel drugs intended for the treatment of bacterial infections in veterinary species. Veterinary Journal (London, England: 1997), 248, 79-85. https://doi.org/10.1016/j.tvjl.2019.04.009
Martín-Jiménez, T., & Riviere, J. E. (1998). Population pharmacokinetics in veterinary medicine: Potential use for therapeutic drug monitoring and prediction of tissue residues. Journal of Veterinary Pharmacology and Therapeutics, 21(3), 167-189.
McCrackin, M. A., Helke, K. L., Galloway, A. M., Poole, A. Z., Salgado, C. D., & Marriott, B. P.(2016). Effect of antimicrobial use in agricultural animals on drug-resistant foodborne campylobacteriosis in humans: A systematic literature review. Critical Reviews in Food Science and Nutrition, 56(13), 2115-2132. https://doi.org/10.1080/10408398.2015.1119798
McEwen, S. A., & Fedorka-Cray, P. J. (2002). Antimicrobial use and resistance in animals. Clinical Infectious Diseases, 34(s3), S93-S106. https://doi.org/10.1086/340246
Melchior, M. B., Fink-Gremmels, J., & Gaastra, W. (2007). Extended antimicrobial susceptibility assay for Staphylococcus aureus isolates from bovine mastitis growing in biofilms. Veterinary Microbiology, 125(1-2), 141-149. https://doi.org/10.1016/j.vetmic.2007.05.019
Melchior, M. B., Vaarkamp, H., & Fink-Gremmels, J. (2006). Biofilms: A role in recurrent mastitis infections? Veterinary Journal (London, England: 1997), 171(3), 398-407. https://doi.org/10.1016/j.tvjl.2005.01.006
Menge, M., Rose, M., Bohland, C., Zschiesche, E., Kilp, S., Metz, W., … Nürnberger, M. (2012). Pharmacokinetics of tildipirosin in bovine plasma, lung tissue, and bronchial fluid (from live, nonanesthetized cattle). Journal of Veterinary Pharmacology and Therapeutics, 35(6), 550-559. https://doi.org/10.1111/j.1365-2885.2011.01349.x
Mengelers, M. J., Hougee, P. E., Janssen, L. H., & Van Miert, A. S. (1997). Structure-activity relationships between antibacterial activities and physicochemical properties of sulfonamides. Journal of Veterinary Pharmacology and Therapeutics, 20(4), 276-283.
Mengelers, M. J., Kleter, G. A., Hoogenboom, L. A., Kuiper, H. A., & Van Miert, A. S. (1997). The biotransformation of sulfadimethoxine, sulfadimidine, sulfamethoxazole, trimethoprim and aditoprim by primary cultures of pig hepatocytes. Journal of Veterinary Pharmacology and Therapeutics, 20(1), 24-32.
Mengelers, M. J., van Gogh, E. R., Huveneers, M. B., Hougee, P. E., Kuiper, H. A., Pijpers, A., … van Miert, A. S. (2001). Pharmacokinetics of sulfadimethoxine and sulfamethoxazole in combination with trimethoprim after oral single- and multiple-dose administration to healthy pigs. Veterinary Research Communications, 25(6), 461-481.
Mevius, D. J., Sprenger, M. J., & Wegener, H. C. (1999). EU conference “The Microbial Threat”. International Journal of Antimicrobial Agents, 11(2), 101-105. https://doi.org/10.1016/s0924-8579(98)00093-4
Meyer Jones, L. (1965). Veterinary pharmacology and therapeutics (3rd ed.). Ames, IA: Iowa State University Press.
Middleton, J., Luby, C., & Adams, D. (2009). Efficacy of vaccination against staphylococcal mastitis: A review and new data. Veterinary Microbiology, 134(1-2), 192-198. https://doi.org/10.1016/j.vetmic.2008.09.053
Midtlyng, P. J., Grave, K., & Horsberg, T. E. (2011). What has been done to minimize the use of antibacterial and antiparasitic drugs in Norwegian aquaculture?: Minimize the use of antibacterial and antiparasitic drugs. Aquaculture Research, 42, 28-34. https://doi.org/10.1111/j.1365-2109.2010.02726.x
Modric, S., & Martinez, M. (2011). Patient variation in veterinary medicine-Part II-influence of physiological variables. Journal of Veterinary Pharmacology and Therapeutics, 34(3), 209-223. https://doi.org/10.1111/j.1365-2885.2010.01249.x
Monnet, D. L., Ferech, M., Frimodt-Møller, N., & Goossens, H. (2005). The more antibacterial trade names, the more consumption of antibacterials: A European study. Clinical Infectious Diseases: an Official Publication of the Infectious Diseases Society of America, 41(1), 114-117. https://doi.org/10.1086/430822
Mudd, A. (1996a). Vancomycin resistance and avoparcin. The Lancet, 347(9012), 1412. https://doi.org/10.1016/S0140-6736(96)91055-7
Mudd, A. J. (1996b). Is it time to ban all antibiotics as animal growth-promoting agents? The Lancet, 348(9039), 1454-1455. https://doi.org/10.1016/S0140-6736(04)70103-8
Mueller, J. H., & Hinton, J. (1941). A protein-free medium for primary isolation of the Gonococcus and Meningococcus. Experimental Biology and Medicine, 48(1), 330-333. https://doi.org/10.3181/00379727-48-13311
Mughini-Gras, L., Dorado-García, A., van Duijkeren, E., van den Bunt, G., Dierikx, C. M., Bonten, M. J. M., … Heederik, D. J. J., & ESBL Attribution Consortium (2019). Attributable sources of community-acquired carriage of Escherichia coli containing β-lactam antibiotic resistance genes: A population-based modelling study. The Lancet. Planetary Health, 3(8), e357-e369. https://doi.org/10.1016/S2542-5196(19)30130-5
Mulders, M. N., Haenen, A. P. J., Geenen, P. L., Vesseur, P. C., Poldervaart, E. S., Bosch, T., … Van De Giessen, A. W. (2010). Prevalence of livestock-associated MRSA in broiler flocks and risk factors for slaughterhouse personnel in The Netherlands. Epidemiology and Infection, 138(05), 743. https://doi.org/10.1017/S0950268810000075
Nelson, J. M., Chiller, T. M., Powers, J. H., & Angulo, F. J. (2007). Fluoroquinolone-resistant Campylobacter species and the withdrawal of fluoroquinolones from use in poultry: A public health success story. Clinical Infectious Diseases: an Official Publication of the Infectious Diseases Society of America, 44(7), 977-980. https://doi.org/10.1086/512369
Nord, C. E. (1993). The effect of antimicrobial agents on the ecology of the human intestinal microflora. Veterinary Microbiology, 35(3-4), 193-197.
Nottebrock, H., & Then, R. (1977). Thymidine concentrations in serum and urine of different animal species and man. Biochemical Pharmacology, 26(22), 2175-2179. https://doi.org/10.1016/0006-2952(77)90271-4
Nouws, J. F. (1981). Microbiological assay methods for sulfonamides in animal tissues, serum, and milk. The Veterinary Quarterly, 3(3), 136-142. https://doi.org/10.1080/01652176.1981.9693814
Nouws, J. F. M. (1984). Irritation, bioavailability, and residue aspects often oxytetracycline formulations administered intramuscularly to pigs. Veterinary Quarterly, 6(2), 80-84. https://doi.org/10.1080/01652176.1984.9693916
Nouws, J. F. M., Smulders, A., & Rappalini, M. (1990). A comparative study on irritation and residue aspects of five oxytetracycline formulations administered intramuscularly to calves, pigs and sheep. Veterinary Quarterly, 12(3), 129-138. https://doi.org/10.1080/01652176.1990.9694257
Nouws, J. F., Vree, T. B., Baakman, M., Driessens, F., Breukink, H. J., & Mevius, D. (1986). Age and dosage dependency in the plasma disposition and the renal clearance of sulfamethazine and its N4-acetyl and hydroxy metabolites in calves and cows. American Journal of Veterinary Research, 47(3), 642-649.
Nouws, J. F., Vree, T. B., Breukink, H. J., Baakman, M., Driessens, F., & Smulders, A. (1985). Dose dependent disposition of sulphadimidine and of its N4-acetyl and hydroxy metabolites in plasma and milk of dairy cows. The Veterinary Quarterly, 7(3), 177-186. https://doi.org/10.1080/01652176.1985.9693980
Nouws, J. F., Vree, T. B., Tijhuis, M., & Baakman, M. (1983). The acetylation-deacetylation equilibrium of sulfadimidine in ruminant calves. The Veterinary Quarterly, 5(1), 41-48. https://doi.org/10.1080/01652176.1983.9693871
Nouws, J. F. M., & Ziv, G. (1978). Tissue Distribution and residues of antibiotics in normal and emergency-Slaughtered dairy cows after intramammary treatment. Journal of Food Protection, 41(1), 8-13. https://doi.org/10.4315/0362-028X-41.1.8
Novak, R. (2011). Are pleuromutilin antibiotics finally fit for human use?: Pleuromutilin antibiotics. Annals of the New York Academy of Sciences, 1241(1), 71-81. https://doi.org/10.1111/j.1749-6632.2011.06219.x
O’Connor, A. M., Yuan, C., Cullen, J. N., Coetzee, J. F., da Silva, N., & Wang, C. (2016). A mixed treatment meta-analysis of antibiotic treatment options for bovine respiratory disease-An update. Preventive Veterinary Medicine, 132, 130-139. https://doi.org/10.1016/j.prevetmed.2016.07.003
Olaitan, A. O., Morand, S., & Rolain, J.-M. (2016). Emergence of colistin-resistant bacteria in humans without colistin usage: A new worry and cause for vigilance. International Journal of Antimicrobial Agents, 47(1), 1-3. https://doi.org/10.1016/j.ijantimicag.2015.11.009
Oliver, S. P., Murinda, S. E., & Jayarao, B. M.(2011). Impact of antibiotic use in adult dairy cows on antimicrobial resistance of veterinary and human pathogens: A comprehensive review. Foodborne Pathogens and Disease, 8(3), 337-355. https://doi.org/10.1089/fpd.2010.0730
O'Neill, J. (2014). Review on antimicrobial resistance antimicrobial resistance: Tackling a crisis for the health and wealth of nations. London: Review on Antimicrobial Resistance. Retrieved from >https://amr-review.org/sites/default/files/AMR%20Review%20Paper%20-%20Tackling%20a%20crisis%20for%20the%20health%20and%20wealth%20of %20nations_1.pdf
Page, S. W. (1991). Chloramphenicol 1. Hazards of use and the current regulatory environment. Australian Veterinary Journal, 68(1), 1-2.
Palmer, G. H., Buswell, J. F., Dowrick, J. S., & Yeoman, G. H. (1976). Amoxycillin: A new veterinary penicillin. The Veterinary Record, 99(5), 84-85.
Papich, M. G. (2012). Selection of antibiotics for meticillin-resistant Staphylococcus pseudintermedius: Time to revisit some old drugs?: Meticillin-resistant Staphylococcus pseudintermedius. Veterinary Dermatology, 23(4), 352-e64. https://doi.org/10.1111/j.1365-3164.2011.01030.x
Papich, M. G. (2013). Antimicrobials, susceptibility testing, and minimum inhibitory concentrations (MIC) in veterinary infection treatment. Veterinary Clinics of North America: Small Animal Practice, 43(5), 1079-1089. https://doi.org/10.1016/j.cvsm.2013.04.005
Papich, M. G. (2014). Pharmacokinetic-pharmacodynamic (PK-PD) modeling and the rational selection of dosage regimes for the prudent use of antimicrobial drugs. Veterinary Microbiology, 171(3-4), 480-486. https://doi.org/10.1016/j.vetmic.2013.12.021
Paukner, S., & Riedl, R. (2017). Pleuromutilins: potent drugs for resistant bugs-Mode of action and resistance. Cold Spring Harbor Perspectives in Medicine, 7(1), a027110. https://doi.org/10.1101/cshperspect.a027110
Pelligand, L., Lees, P., Sidhu, P. K., & Toutain, P.-L. (2019). Semi-mechanistic modeling of florfenicol time-kill curves and in silico dose fractionation for calf respiratory pathogens. Frontiers in Microbiology, 10, 1237. https://doi.org/10.3389/fmicb.2019.01237
Pereira, R. V. V., Carroll, L. M., Lima, S., Foditsch, C., Siler, J. D., Bicalho, R. C., & Warnick, L. D. (2018). Impacts of feeding preweaned calves milk containing drug residues on the functional profile of the fecal microbiota. Scientific Reports, 8(1), 554. https://doi.org/10.1038/s41598-017-19021-2
Perreten, V., Kadlec, K., Schwarz, S., Gronlund Andersson, U., Finn, M., Greko, C., … Guardabassi, L. (2010). Clonal spread of methicillin-resistant Staphylococcus pseudintermedius in Europe and North America: An international multicentre study. Journal of Antimicrobial Chemotherapy, 65(6), 1145-1154. https://doi.org/10.1093/jac/dkq078
Perry, W., & Golan, Y. (2019). Therapeutic potential of lefamulin in the treatment of community acquired pneumonia. Future Microbiology, 14, 927-939. https://doi.org/10.2217/fmb-2019-0027
Phillips, I. (2003). Does the use of antibiotics in food animals pose a risk to human health? A critical review of published data. Journal of Antimicrobial Chemotherapy, 53(1), 28-52. https://doi.org/10.1093/jac/dkg483
Phillips, I. (2007). Withdrawal of growth-promoting antibiotics in Europe and its effects in relation to human health. International Journal of Antimicrobial Agents, 30(2), 101-107. https://doi.org/10.1016/j.ijantimicag.2007.02.018
Piddock, L. J. V. (1996). Does the use of antimicrobial agents in veterinary medicine and animal husbandry select antibiotic-resistant bacteria that infect man and compromise antimicrobial chemotherapy? Journal of Antimicrobial Chemotherapy, 38(1), 1-3. https://doi.org/10.1093/jac/38.1.1
Pires, S. M., Duarte, A. S., & Hald, T. (2018). Source attribution and risk assessment of antimicrobial resistance. Microbiology Spectrum, 6(3), 1-17. https://doi.org/10.1128/microbiolspec.ARBA-0027-2017
Pomba, C., Rantala, M., Greko, C., Baptiste, K. E., Catry, B., van Duijkeren, E., … Törneke, K. (2016). Public health risk of antimicrobial resistance transfer from companion animals. Journal of Antimicrobial Chemotherapy, 72(4), 957-968. https://doi.org/10.1093/jac/dkw481
Prescott, J. F. (2017). History and current use of antimicrobial drugs in veterinary medicine. Microbiology Spectrum, 5(6), 1-15. https://doi.org/10.1128/microbiolspec.ARBA-0002-2017
Prescott, J. F., & Baggot, J. D. (1988). Antimicrobial therapy in veterinary medicine. Oxford, UK: Blackwell Scientific Publication.
Rajamuthiah, R., Fuchs, B. B., Conery, A. L., Kim, W., Jayamani, E., Kwon, B., … Mylonakis, E. (2015). Repurposing salicylanilide anthelmintic drugs to combat drug resistant Staphylococcus aureus. PLoS One, 10(4), e0124595. https://doi.org/10.1371/journal.pone.0124595
Randall, C. J. (1969). The Swann Committee. The Veterinary Record, 85(22), 616-621. https://doi.org/10.1136/vr.85.22.616
Rasmussen, F. (1958). Mammary excretion of sulphonamides. Acta Pharmacologica Et Toxicologica, 15(2), 139-148.
Rasmussen, F. (1959). Mammary excretion of benzylpenicillin, erythromycin, and penethamate hydroiodide. Acta Pharmacologica Et Toxicologica, 16, 194-200.
Rhouma, M., Beaudry, F., Thériault, W., & Letellier, A. (2016). Colistin in pig production: Chemistry, mechanism of antibacterial action, microbial resistance emergence, and one health perspectives. Frontiers in Microbiology, 11. http://journal.frontiersin.org/article/10.3389/fmicb.2016.01789/full
Richez, P., & Burch, D. G. S. (2016). Colistin in animals: A high risk for resistance selection in Europe? The Veterinary Record, 178(4), 101-102. https://doi.org/10.1136/vr.i381
Riviere, J. E., Craigmill, A. L., & Sundlof, S. F. (1986). Food Animal Residue Avoidance Databank (FARAD): An automated pharmacologic databank for drug and chemical residue avoidance. Journal of Food Protection, 49(10), 826-830. https://doi.org/10.4315/0362-028X-49.10.826
Riviere, J. E., Gabrielsson, J., Fink, M., & Mochel, J. (2016). Mathematical modeling and simulation in animal health. Part I: Moving beyond pharmacokinetics. Journal of Veterinary Pharmacology and Therapeutics, 39(3), 213-223. https://doi.org/10.1111/jvp.12278
Rizzo, L., Manaia, C., Merlin, C., Schwartz, T., Dagot, C., Ploy, M. C., … Fatta-Kassinos, D. (2013). Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: A review. The Science of the Total Environment, 447, 345-360. https://doi.org/10.1016/j.scitotenv.2013.01.032
Roach, R. W., & Hignett, S. L. (1945). Chemotherapy in the treatment of chronic contagious mastitis-II. The Veterinary Journal (1900), 101(5), 99-108. https://doi.org/10.1016/S0372-5545(17)32152-1
Roberts, S. J., & Kiesel, G. K. (1948). Treatment of pneumonia in cattle. Journal of the American Veterinary Medical Association, 112(850), 34-39.
Roselli, M., Finamore, A., Britti, M. S., Bosi, P., Oswald, I., & Mengheri, E. (2005). Alternatives to in-feed antibiotics in pigs: Evaluation of probiotics, zinc or organic acids as protective agents for the intestinal mucosa. A comparison of in vitro and in vivo results. Animal Research, 54(3), 203-218. https://doi.org/10.1051/animres:2005012
Rutten, C. J., Velthuis, A. G. J., Steeneveld, W., & Hogeveen, H. (2013). Invited review: Sensors to support health management on dairy farms. Journal of Dairy Science, 96(4), 1928-1952. https://doi.org/10.3168/jds.2012-6107
Salter, R. S., Douglas, D., McRobbie, L., Quintana, J., Legg, D., Schwartz, J., … Markovsky, R. (2011). Validation of the charm 3 SL3 beta-lactam test for screening raw milk in compliance with the U.S. pasteurized milk ordinance. Performance Tested Method 071002. Journal of AOAC International, 94(1), 348-357.
Sanders, P. (2000). Editorial. International Journal of Antimicrobial Agents, 14(4), 269-270. https://doi.org/10.1016/S0924-8579(00)00134-5
Sanders, P., Henri, J., & Laurentie, M. (2016). Tools to evaluate pharmacokinetics data for establishing maximum residue limits for approved veterinary drugs: Examples from JECFA’s work. Drug Testing and Analysis, 8(5-6), 565-571. https://doi.org/10.1002/dta.2006
Scheidy, S. F. (1951). Antibiotic therapy in veterinary medicine. Journal of the American Veterinary Medical Association, 118(889), 213-220.
Schrijver, R., Stijntjes, M., Rodríguez-Baño, J., Tacconelli, E., Babu Rajendran, N., & Voss, A. (2018). Review of antimicrobial resistance surveillance programmes in livestock and meat in EU with focus on humans. Clinical Microbiology and Infection: the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 24(6), 577-590. https://doi.org/10.1016/j.cmi.2017.09.013
Schwarz, S., Enne, V. I., & van Duijkeren, E. (2016). 40 years of veterinary papers in JAC - what have we learnt? Journal of Antimicrobial Chemotherapy, 71(10), 2681-2690. https://doi.org/10.1093/jac/dkw363
Scott, A. M., Beller, E., Glasziou, P., Clark, J., Ranakusuma, R. W., Byambasuren, O., … Mar, C. D. (2018). Is antimicrobial administration to food animals a direct threat to human health? A rapid systematic review. International Journal of Antimicrobial Agents, 52(3), 316-323. https://doi.org/10.1016/j.ijantimicag.2018.04.005
Shallcross, L. J., & Davies, S. C. (2014). The World Health Assembly resolution on antimicrobial resistance. Journal of Antimicrobial Chemotherapy, 69(11), 2883-2885. https://doi.org/10.1093/jac/dku346
Shryock, T. R. (2004). The future of anti-infective products in animal health. Nature Reviews Microbiology, 2(5), 425-430. https://doi.org/10.1038/nrmicro887
Silbergeld, E. K., Graham, J., & Price, L. B. (2008). Industrial food animal production, antimicrobial resistance, and human health. Annual Review of Public Health, 29(1), 151-169. https://doi.org/10.1146/annurev.publhealth.29.020907.090904
Singer, A. C., Shaw, H., Rhodes, V., & Hart, A. (2016). Review of antimicrobial resistance in the environment and its relevance to environmental regulators. Frontiers in Microbiology, 7, 1728. https://doi.org/10.3389/fmicb.2016.01728
Sisodia, C. S., & Stowe, C. M. (1964). The mechanism of drug secretion into bovine milk. Annals of the New York Academy of Sciences, 111, 650-661. https://doi.org/10.1111/j.1749-6632.1964.tb53133.x
Smith, H. W. (1968). Anti-microbial drugs in animal feeds. Nature, 218(5143), 728-731.
Smith, H. W. (1969). Transfer of antibiotic resistance from animal and human strains of Escherichia coli to resident E. coli in the alimentary tract of man. Lancet (London, England), 1(7607), 1174-1176.
Smith, H. W. (1970). The transfer of antibiotic resistance between strains of enterobacteria in chicken, calves and pigs. Journal of Medical Microbiology, 3(1), 165-180. https://doi.org/10.1099/00222615-3-1-165
Smith, H. W. (1971). The effect of the use of antibacterial drugs on the emergence of drug-resistant bacteria in animals. Advances in Veterinary Science and Comparative Medicine, 15, 67-100.
Stegemann, M. R., Sherington, J., & Blanchflower, S. (2006). Pharmacokinetics and pharmacodynamics of cefovecin in dogs. Journal of Veterinary Pharmacology and Therapeutics, 29(6), 501-511. https://doi.org/10.1111/j.1365-2885.2006.00801.x
Stegemann, M. R., Sherington, J., Coati, N., Brown, S. A., & Blanchflower, S. (2006). Pharmacokinetics of cefovecin in cats. Journal of Veterinary Pharmacology and Therapeutics, 29(6), 513-524. https://doi.org/10.1111/j.1365-2885.2006.00795.x
Steinman, A., Isoherranen, N., Ashoach, O., & Soback, S. (2002). Pharmacokinetics of gentamicin C1, C1a and C2 in horses after single intravenous dose. Equine Veterinary Journal, 34(6), 615-618.
Stockwell, V. O., & Duffy, B. (2012). Use of antibiotics in plant agriculture. Revue Scientifique Et Technique (International Office of Epizootics), 31(1), 199-210. https://doi.org/10.20506/rst.31.1.2104
Stowe, C. M. (1965). The Sulfonamides. In L. Meyer Jones (Ed.), Veterinary pharmacology and therapeutics (3rd ed., pp. 458-502). Ames, IA: Iowa State University Press.
Stowe, C. M. (1976). History of veterinary pharmacotherapeutics in the United States. Journal of the American Veterinary Medical Association, 169(1), 83-89.
Subbiah, M., Shah, D. H., Besser, T. E., Ullman, J. L., & Call, D. R. (2012). Urine from treated cattle drives selection for cephalosporin resistant Escherichia coli in soil. PLoS One, 7(11), e48919. https://doi.org/10.1371/journal.pone.0048919
Sun, Y., Scruggs, D. W., Peng, Y., Johnson, J. R., & Shukla, A. J. (2004). Issues and challenges in developing long-acting veterinary antibiotic formulations. Advanced Drug Delivery Reviews, 56(10), 1481-1496. https://doi.org/10.1016/j.addr.2004.02.009
Sundlof, S. F., Craigmill, A. C., & Riviere, J. E. (1986). Food Animal Residue Avoidance Databank (FARAD): A pharmacokinetic-based information resource. Journal of Veterinary Pharmacology and Therapeutics, 9(3), 237-245.
Syriopoulou, V. P., Harding, A. L., Goldmann, D. A., & Smith, A. L. (1981). In vitro antibacterial activity of fluorinated analogs of chloramphenicol and thiamphenicol. Antimicrobial Agents and Chemotherapy, 19(2), 294-297. https://doi.org/10.1128/aac.19.2.294
Tang, K. L., Caffrey, N. P., Nóbrega, D. B., Cork, S. C., Ronksley, P. E., Barkema, H. W., … Ghali, W. A. (2017). Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human beings: A systematic review and meta-analysis. The Lancet. Planetary Health, 1(8), e316-e327. https://doi.org/10.1016/S2542-5196(17)30141-9
Tello, A., Austin, B., & Telfer, T. C. (2012). Selective pressure of antibiotic pollution on bacteria of importance to public health. Environmental Health Perspectives, 120(8), 1100-1106. https://doi.org/10.1289/ehp.1104650
Teske, R. H. (1993). Microbiological significance of drug residues in food: Welcome and introduction. Veterinary and Human Toxicology, 35(Suppl 1), 1-2.
Thacker, P. A. (2013). Alternatives to antibiotics as growth promoters for use in swine production: A review. Journal of Animal Science and Biotechnology, 4(1), 35. https://doi.org/10.1186/2049-1891-4-35
Thiele-Bruhn, S. (2003). Pharmaceutical antibiotic compounds in soils - A review. Journal of Plant Nutrition and Soil Science, 166(2), 145-167. https://doi.org/10.1002/jpln.200390023
Thomas, N., & Lo, C. Y. (2020). The macrosecuritization of antimicrobial resistance in China. Journal of Global Security Studies, 5(2), 361-378. https://doi.org/10.1093/jogss/ogz038
Toutain, P.-L., & Bousquet-Melou, A. (2013). The consequences of generic marketing on antibiotic consumption and the spread of microbial resistance: The need for new antibiotics. Journal of Veterinary Pharmacology and Therapeutics, 36(5), 420-424. https://doi.org/10.1111/jvp.12061
Toutain, P. L., & Bousquet-Melou, A. (2014). Rebuttal to the reaction of the EGGVP to the review article “the consequences of generic marketing on antibiotic consumption and the spread of microbial resistance: The need for new antibiotics”. Journal of Veterinary Pharmacology and Therapeutics, 37(6), 618-623. https://doi.org/10.1111/jvp.12166
Toutain, P.-L., Bousquet-Mélou, A., Damborg, P., Ferran, A. A., Mevius, D., Pelligand, L., … Lees, P. (2017). En route towards European clinical breakpoints for veterinary antimicrobial susceptibility testing: A position paper explaining the VetCAST approach. Frontiers in Microbiology, 8, 2344. https://doi.org/10.3389/fmicb.2017.02344
Toutain, P.-L., del Castillo, J. R. E., & Bousquet-Mélou, A. (2002). The pharmacokinetic-pharmacodynamic approach to a rational dosage regimen for antibiotics. Research in Veterinary Science, 73(2), 105-114. https://doi.org/10.1016/S0034-5288(02)00039-5
Toutain, P.-L., Ferran, A. A., Bousquet-Melou, A., Pelligand, L., & Lees, P. (2016). Veterinary medicine needs new green antimicrobial drugs. Frontiers in Microbiology, 7, 1196. https://doi.org/10.3389/fmicb.2016.01196
Toutain, P.-L., Potter, T., Pelligand, L., Lacroix, M., Illambas, J., & Lees, P. (2017). Standard PK/PD concepts can be applied to determine a dosage regimen for a macrolide: The case of tulathromycin in the calf. Journal of Veterinary Pharmacology and Therapeutics, 40(1), 16-27. https://doi.org/10.1111/jvp.12333
Toutain, P.-L., Sidhu, P. K., Lees, P., Rassouli, A., & Pelligand, L. (2019). VetCAST method for determination of the pharmacokinetic-pharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol antimicrobial susceptibility testing in cattle. Frontiers in Microbiology, 10, 1310. https://doi.org/10.3389/fmicb.2019.01310
Tschape, H. (1994). The spread of plasmids as a function of bacterial adaptability. FEMS Microbiology Ecology, 15(1-2), 23-31. https://doi.org/10.1111/j.1574-6941.1994.tb00226.x
van Belkum, A. (2008). Methicillin-resistant and -susceptible Staphylococcus aureus sequence type 398 in pigs and humans. Emerging Infectious Diseases, 14(3), 479-483. https://doi.org/10.3201/eid1403.0760
van Belkum, A., Burnham, C.-A.-D., Rossen, J. W. A., Mallard, F., Rochas, O., & Dunne, W. M. (2020). Innovative and rapid antimicrobial susceptibility testing systems. Nature Reviews Microbiology, 18, 299-311. https://doi.org/10.1038/s41579-020-0327-x
Van Boeckel, T. P., Brower, C., Gilbert, M., Grenfell, B. T., Levin, S. A., Robinson, T. P., … Laxminarayan, R. (2015). Global trends in antimicrobial use in food animals. Proceedings of the National Academy of Sciences, 112(18), 5649-5654. https://doi.org/10.1073/pnas.1503141112
Van Boeckel, T. P., Glennon, E. E., Chen, D., Gilbert, M., Robinson, T. P., Grenfell, B. T., … Laxminarayan, R. (2017). Reducing antimicrobial use in food animals. Science, 357(6358), 1350-1352. https://doi.org/10.1126/science.aao1495
van Boven, M., Veldman, K. T., de Jong, M. C. M., & Mevius, D. J. (2003). Rapid selection of quinolone resistance in Campylobacter jejuni but not in Escherichia coli in individually housed broilers. The Journal of Antimicrobial Chemotherapy, 52(4), 719-723. https://doi.org/10.1093/jac/dkg402
van den Bogaard, A. E., Jensen, L. B., & Stobberingh, E. E. (1997). Vancomycin-resistant Enterococci in Turkeys and farmers. New England Journal of Medicine, 337(21), 1558-1559. https://doi.org/10.1056/NEJM199711203372117
van den Bogaard, A., & Stobberingh, E. (1996). Time to ban all antibiotics as animal growth-promoting agents? The Lancet, 348(9027), 619. https://doi.org/10.1016/S0140-6736(05)64838-6
van den Bogaard, A. E., & Stobberingh, E. E. (1999). Antibiotic usage in animals: Impact on Bacterial resistance and public health. Drugs, 58(4), 589-607. https://doi.org/10.2165/00003495-199958040-00002
van Duijkeren, E., Greko, C., Pringle, M., Baptiste, K. E., Catry, B., Jukes, H., … Torneke, K.(2014). Pleuromutilins: Use in food-producing animals in the European Union, development of resistance and impact on human and animal health. Journal of Antimicrobial Chemotherapy, 69(8), 2022-2031. https://doi.org/10.1093/jac/dku123
van Gogh, H., van Deurzen, E. J., van Duin, C. T., & van Miert, A. S. (1984). Effect of staphylococcal enterotoxin B-induced diarrhoea on the pharmacokinetics of sulphadimidine in the goat. Journal of Veterinary Pharmacology and Therapeutics, 7(4), 303-305.
Van Gogh, H., & Van Miert, A. S. (1977). The absorption of sulfonamides from the gastrointestinal tract during pyrogen-induced fever in kids and goats. Zentralblatt Fur Veterinarmedizin. Reihe A, 24(6), 503-510.
van Hoek, A. H. A. M., Mevius, D., Guerra, B., Mullany, P., Roberts, A. P., & Aarts, H. J. M. (2011). Acquired antibiotic resistance genes: An overview. Frontiers in Microbiology, 2, 1-27. https://doi.org/10.3389/fmicb.2011.00203
van Miert, A. (1990). Influence of febrile disease on the pharmacokinetics of veterinary drugs. Annales De Recherches Veterinaires. Annals of Veterinary Research, 21(Suppl 1), 11S-28S.
van Miert, A. S. (1994). The sulfonamide-diaminopyrimidine story. Journal of Veterinary Pharmacology and Therapeutics, 17(4), 309-316.
Van Miert, A. S., & Atmakusuma, A. (1970). Comparative observations on the production of fever by bacterial pyrogens and leucocytic pyrogen in goats and rabbits. Zentralblatt Fur Veterinarmedizin. Reihe A, 17(2), 174-184.
van Miert, A. S., & Frens, J. (1968). The reaction of different animal species to bacterial pyrogens. Zentralblatt Fur Veterinarmedizin. Reihe A, 15(6), 532-543.
Van Schyndel, S. J., Carrier, J., Bogado Pascottini, O., & LeBlanc, S. J. (2018). The effect of pegbovigrastim on circulating neutrophil count in dairy cattle: A randomized controlled trial. PLoS One, 13(6), e0198701. https://doi.org/10.1371/journal.pone.0198701
Vandenberg, O., Durand, G., Hallin, M., Diefenbach, A., Gant, V., Murray, P., … van Belkum, A. (2020). Consolidation of clinical microbiology laboratories and introduction of transformative technologies. Clinical Microbiology Reviews, 33(2), 1-19. https://doi.org/10.1128/CMR.00057-19
Varma, K. J., Adams, P. E., Powers, T. E., Powers, J. D., & Lamendola, J. F. (1986). Pharmacokinetics of florfenicol in veal calves. Journal of Veterinary Pharmacology and Therapeutics, 9(4), 412-425. https://doi.org/10.1111/j.1365-2885.1986.tb00062.x
Vasseur, M. V., Lacroix, M. Z., Toutain, P.-L., Bousquet-Melou, A., & Ferran, A. A. (2017). Infection-stage adjusted dose of beta-lactams for parsimonious and efficient antibiotic treatments: A Pasteurella multocida experimental pneumonia in mice. PLoS One, 12(8), e0182863. https://doi.org/10.1371/journal.pone.0182863
Vasseur, M. V., Laurentie, M., Rolland, J.-G., Perrin-Guyomard, A., Henri, J., Ferran, A. A., … Bousquet-Mélou, A. (2014). Low or high doses of cefquinome targeting low or high bacterial inocula cure Klebsiella pneumoniae lung infections but differentially impact the levels of antibiotic resistance in fecal flora. Antimicrobial Agents and Chemotherapy, 58(3), 1744-1748. https://doi.org/10.1128/AAC.02135-13
Vecino, E. (2014). Reaction to the review article “the consequences of generic marketing on antibiotic consumption and the spread of microbial resistance: The need for new antibiotics”. Journal of Veterinary Pharmacology and Therapeutics, 37(6), 615-617. https://doi.org/10.1111/jvp.12167
Verdon, E., Couedor, P., Roudaut, B., & Sandérs, P. (2005). Multiresidue method for simultaneous determination of ten quinolone antibacterial residues in multimatrix/multispecies animal tissues by liquid chromatography with fluorescence detection: Single laboratory validation study. Journal of AOAC International, 88(4), 1179-1192.
Vermeulen, B. (2002). Drug administration to poultry. Advanced Drug Delivery Reviews, 54(6), 795-803. https://doi.org/10.1016/S0169-409X(02)00069-8
Villarino, N., Brown, S. A., & Martín-Jiménez, T. (2013). The role of the macrolide tulathromycin in veterinary medicine. Veterinary Journal (London, England: 1997), 198(2), 352-357. https://doi.org/10.1016/j.tvjl.2013.07.032
Wagenaar, J. A., Bergen, M. A. P. V., Mueller, M. A., Wassenaar, T. M., & Carlton, R. M. (2005). Phage therapy reduces Campylobacter jejuni colonization in broilers. Veterinary Microbiology, 109(3-4), 275-283. https://doi.org/10.1016/j.vetmic.2005.06.002
Walker, R. (2000). Current topics in veterinary drug therapy: The use of fluoroquinolones for companion animal antimicrobial therapy. Australian Veterinary Journal, 78(2), 84-90. https://doi.org/10.1111/j.1751-0813.2000.tb10528.x
Wallerstein, R. O., Condit, P. K., Kasper, C. K., Brown, J. W., & Morrison, F. R. (1969). Statewide study of chloramphenicol therapy and fatal aplastic anemia. JAMA, 208(11), 2045-2050.
Wallinga, D., & Burch, D. G. S. (2013). Does adding routine antibiotics to animal feed pose a serious risk to human health? BMJ (Clinical Research Ed.), 347, f4214. https://doi.org/10.1136/bmj.f4214
Wang, J., MacNeil, J. D., & Kay, J. F. (2012). Chemical analysis of antibiotic residues in food. Hoboken, NJ: Wiley & Sons.
Watanabe, T., & Fukasawa, T. (1961). Episome-mediated transfer of drug resistance in Enterobacteriaceae. III. Transduotion of resistance factors. Journal of Bacteriology, 82, 202-209.
Watson, A. D. J. (1972). Chloramphenicol plasma levels in the dog: A comparison of oral, subcutaneous and intramuscular administration. Journal of Small Animal Practice, 13(3), 147-152. https://doi.org/10.1111/j.1748-5827.1972.tb06323.x
Watson, A. (1991). Chloramphenicol 2. Clinical pharmacology in dogs and cats. Australian Veterinary Journal, 68(1), 2-5. https://doi.org/10.1111/j.1751-0813.1991.tb09827.x
Weese, J. S., Blondeau, J. M., Boothe, D., Breitschwerdt, E. B., Guardabassi, L., Hillier, A., … Sykes, J. E. (2011). Antimicrobial use guidelines for treatment of urinary tract disease in dogs and cats: Antimicrobial guidelines working group of the International Society for Companion Animal Infectious Diseases. Veterinary Medicine International, 2011, 1-9. https://doi.org/10.4061/2011/263768
Weese, J. S., Blondeau, J., Boothe, D., Guardabassi, L. G., Gumley, N., Papich, M., … Sykes, J. (2019). International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats. The Veterinary Journal, 247, 8-25. https://doi.org/10.1016/j.tvjl.2019.02.008
Weese, J. S., Giguère, S., Guardabassi, L., Morley, P. S., Papich, M., Ricciuto, D. R., & Sykes, J. E. (2015). ACVIM consensus statement on therapeutic antimicrobial use in animals and antimicrobial resistance. Journal of Veterinary Internal Medicine, 29(2), 487-498. https://doi.org/10.1111/jvim.12562
Weese, J. S., & van Duijkeren, E. (2010). Methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius in veterinary medicine. Veterinary Microbiology, 140(3-4), 418-429. https://doi.org/10.1016/j.vetmic.2009.01.039
Wegener, H. C. (1998). Historical yearly usage of glycopeptides for animals and humans: The American-European Paradox Revisited. Antimicrobial Agents and Chemotherapy, 42(11), 3049. https://doi.org/10.1128/AAC.42.11.3049
Wegener, H. C., Aarestrup, F. M., Jensen, L. B., Hammerum, A. M., & Bager, F. (1999). Use of antimicrobial growth promoters in food animals and Enterococcus faecium resistance to therapeutic antimicrobial drugs in Europe. Emerging Infectious Diseases, 5(3), 329-335. https://doi.org/10.3201/eid0503.990303
Welch, H. (1957). Problems of antibiotics in food as the food and drug administration sees them. American Journal of Public Health and the Nations Health, 47(6), 701-705. https://doi.org/10.2105/AJPH.47.6.701
Whitehead, M. L., Chambers, D., Lees, P., & Toutain, P. L. (2019). The UK veterinary profession’s response to antimicrobial resistance. Regulatory Rapporteur, 16(3), 10-12.
WHO Advisory Group on Integrated Surveillance of Antimicrobial Resistance, & World Health Organization (2017). Critically important antimicrobials for human medicine: Ranking of antimicrobial agents for risk management of antimicrobial resistance due to non-human use. Retrieved from http://apps.who.int/iris/bitstream/10665/255027/1/9789241512220-eng.pdf
Williamson, J., & Cravens, W. (1972). Feed industry reaction and implications. Journal of Animal Science, 35(6), 1338-1339.
Witkamp, R. F., Nijmeijer, S. M., Monshouwer, M., & Van Miert, A. S. (1995). The antibiotic tiamulin is a potent inducer and inhibitor of cytochrome P4503A via the formation of a stable metabolic intermediate complex. Studies in primary hepatocyte cultures and liver microsomes of the pig. Drug Metabolism and Disposition: the Biological Fate of Chemicals, 23(5), 542-547.
Witkamp, R. F., Nijmeijer, S. M., Yun, H., Noordhoek, J., & van Miert, A. S. (1993). Sulfamethazine as a model compound to assess sex hormone-dependent cytochrome P-450 activity in rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals, 21(3), 441-446.
Witkamp, R. F., Yun, H. I., van't Klooster, G. A., van Mosel, J. F., van Mosel, M., Ensink, J. M., … van Miert, A. S.(1992). Comparative aspects and sex differentiation of plasma sulfamethazine elimination and metabolite formation in rats, rabbits, dwarf goats, and cattle. American Journal of Veterinary Research, 53(10), 1830-1835.
Woodward, K. N. (1998). The use of microbiological end-points in the safety evaluation and elaboration of maximum residue limits for veterinary drugs intended for use in food producing animals. Journal of Veterinary Pharmacology and Therapeutics, 21(1), 47-53.
Wu, G., Day, M. J., Mafura, M. T., Nunez-Garcia, J., Fenner, J. J., Sharma, M., … Mevius, D. (2013). Comparative analysis of ESBL-positive Escherichia coli isolates from animals and humans from the UK, The Netherlands and Germany. PLoS One, 8(9), e75392. https://doi.org/10.1371/journal.pone.0075392
Yang, Y., Feye, K. M., Shi, Z., Pavlidis, H. O., Kogut, M., Ashworth, A. J., & Ricke, S. C.(2019). A historical review on antibiotic resistance of foodborne Campylobacter. Frontiers in Microbiology, 10, 1509. https://doi.org/10.3389/fmicb.2019.01509
Yazdankhah, S., Rudi, K., & Bernhoft, A. (2014). Zinc and copper in animal feed - Development of resistance and co-resistance to antimicrobial agents in bacteria of animal origin. Microbial Ecology in Health & Disease, 25, 1-7. https://doi.org/10.3402/mehd.v25.25862
Zhu, Y.-G., Gillings, M., Simonet, P., Stekel, D., Banwart, S., & Penuelas, J. (2017). Microbial mass movements. Science, 357(6356), 1099-1100. https://doi.org/10.1126/science.aao3007
Zhu, Y.-G., Johnson, T. A., Su, J.-Q., Qiao, M., Guo, G.-X., Stedtfeld, R. D., … Tiedje, J. M. (2013). Diverse and abundant antibiotic resistance genes in Chinese swine farms. Proceedings of the National Academy of Sciences, 110(9), 3435-3440. https://doi.org/10.1073/pnas.1222743110
Ziv, G. (1980a). Practical pharmacokinetic aspects of mastitis therapy-1: Parenteral treatment. Veterinary Medicine, Small Animal Clinician: VM, SAC, 75(2), 277-290.
Ziv, G. (1980b). Practical pharmacokinetic aspects of mastitis therapy-2: Practical & therapeutic applications. Veterinary Medicine, Small Animal Clinician: VM, SAC, 75(3), 469-474.
Ziv, G. (1980c). Practical pharmacokinetic aspects of mastitis therapy-3: Intramammary treatment. Veterinary Medicine, Small Animal Clinician: VM, SAC, 75(4), 657-670.