What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group.
ENIGMA
MRI
bipolar disorder
cortical surface area
cortical thickness
mega-analysis
meta-analysis
neuroimaging
psychiatry
volume
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
31
05
2020
received:
31
03
2020
accepted:
04
06
2020
pubmed:
30
7
2020
medline:
29
3
2022
entrez:
30
7
2020
Statut:
ppublish
Résumé
MRI-derived brain measures offer a link between genes, the environment and behavior and have been widely studied in bipolar disorder (BD). However, many neuroimaging studies of BD have been underpowered, leading to varied results and uncertainty regarding effects. The Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Bipolar Disorder Working Group was formed in 2012 to empower discoveries, generate consensus findings and inform future hypothesis-driven studies of BD. Through this effort, over 150 researchers from 20 countries and 55 institutions pool data and resources to produce the largest neuroimaging studies of BD ever conducted. The ENIGMA Bipolar Disorder Working Group applies standardized processing and analysis techniques to empower large-scale meta- and mega-analyses of multimodal brain MRI and improve the replicability of studies relating brain variation to clinical and genetic data. Initial BD Working Group studies reveal widespread patterns of lower cortical thickness, subcortical volume and disrupted white matter integrity associated with BD. Findings also include mapping brain alterations of common medications like lithium, symptom patterns and clinical risk profiles and have provided further insights into the pathophysiological mechanisms of BD. Here we discuss key findings from the BD working group, its ongoing projects and future directions for large-scale, collaborative studies of mental illness.
Identifiants
pubmed: 32725849
doi: 10.1002/hbm.25098
pmc: PMC8675426
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
56-82Subventions
Organisme : NIMH NIH HHS
ID : T32 MH073526
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : CIHR
ID : 142255
Pays : Canada
Organisme : NIA NIH HHS
ID : T32 AG058507
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH113871
Pays : United States
Organisme : NIMH NIH HHS
ID : R37 MH100041
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH085096
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_17209
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH080912
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH074644
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH100041
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM121312
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH096957
Pays : United States
Organisme : Wellcome Trust
ID : 104036/Z/14/Z
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH060952
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH083968
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH098130
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH059929
Pays : United States
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH095454
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : K08 MH086786
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH116147
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH101111
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH106324
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG058854
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH075007
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 216767/Z/19/Z
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R03 MH105808
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH107703
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH085667
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH090553
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH076971
Pays : United States
Informations de copyright
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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