Hematopoietic stem cells from pluripotent stem cells: Clinical potential, challenges, and future perspectives.
embryo
hematopoiesis
hematopoietic differentiation
hemogenic endothelium
induced pluripotent stem cells
reprogramming
Journal
Stem cells translational medicine
ISSN: 2157-6580
Titre abrégé: Stem Cells Transl Med
Pays: England
ID NLM: 101578022
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
09
06
2020
revised:
01
07
2020
accepted:
08
07
2020
pubmed:
30
7
2020
medline:
1
9
2021
entrez:
30
7
2020
Statut:
ppublish
Résumé
The generation of hematopoietic stem cells (HSCs) from induced pluripotent stem cells (iPSCs) is an active and promising area of research; however, generating engraftable HSCs remains a major obstacle. Ex vivo HSC derivation from renewable sources such as iPSCs offers an experimental tool for studying developmental hematopoiesis, disease modeling, and drug discovery, and yields tremendous therapeutic potential for malignant and nonmalignant hematological disorders. Although initial attempts mostly recapitulated yolk sac primitive/definitive hematopoiesis with inability to engraft, recent advances suggest the feasibility of engraftable HSC derivation from iPSCs utilizing ectopic transcription factor expression. Strategic development for de novo HSC generation includes further investigations of HSC ontogeny, and elucidation of critical signaling pathways, epigenetic modulations, HSC and iPSC microenvironment, and cell-cell interactions that contribute to stem cell biology and function.
Identifiants
pubmed: 32725882
doi: 10.1002/sctm.20-0247
pmc: PMC7695636
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1549-1557Informations de copyright
© 2020 The Authors. STEM CELLS TRANSLATIONAL MEDICINE published by Wiley Periodicals LLC on behalf of AlphaMed Press.
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