The Hidden Burden of Severe Asthma: From Patient Perspective to New Opportunities for Clinicians.
biomarkers
patient’s perspective
precision medicine
severe asthma
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
27 Jul 2020
27 Jul 2020
Historique:
received:
30
06
2020
revised:
15
07
2020
accepted:
20
07
2020
entrez:
31
7
2020
pubmed:
31
7
2020
medline:
31
7
2020
Statut:
epublish
Résumé
Severe asthma is an important topic in respiratory diseases, due to its high impact on morbidity and mortality as well as on health-care resources. The many challenges that still exist in the management of the most difficult-to-treat forms of the disease, and the acknowledgement of the existence of unexplored areas in the pathophysiological mechanisms and the therapeutic targets represent an opportunity to gather experts in the field with the immediate goals to summarize current understanding about the natural history of severe asthma and to identify gaps in knowledge and research opportunities, with the aim to contribute to improved medical care and health outcomes. This article is a consensus document from the "International Course on Severe Asthma" that took place in Palermo, Italy, on May 10-11, 2019. Emerging topics in severe asthma were addressed and discussed among experts, with special focus on patient's needs and research opportunities, with the aim to highlight the unanswered questions in the diagnostic process and therapeutic approach.
Identifiants
pubmed: 32727032
pii: jcm9082397
doi: 10.3390/jcm9082397
pmc: PMC7463666
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Expert Rev Hematol. 2012 Apr;5(2):157-76
pubmed: 22475285
Lancet. 2018 Feb 24;391(10122):783-800
pubmed: 29273246
Isr Med Assoc J. 2004 Apr;6(4):246-8
pubmed: 15115267
Clin Mol Allergy. 2017 Apr 10;15:9
pubmed: 28400707
Adv Clin Exp Med. 2015 Nov-Dec;24(6):1079-83
pubmed: 26771982
J Asthma. 2019 Jan;56(1):87-94
pubmed: 29533692
Am J Respir Crit Care Med. 2017 Aug 1;196(3):283-297
pubmed: 28252317
Thorax. 2006 Feb;61(2):169-76
pubmed: 16443708
BMC Pulm Med. 2016 Dec 9;16(1):180
pubmed: 27938358
Aging Clin Exp Res. 2005 Aug;17(4):287-92
pubmed: 16285194
N Engl J Med. 2007 Mar 29;356(13):1327-37
pubmed: 17392302
Eur Respir J. 2006 May;27(5):951-6
pubmed: 16446314
Chest. 1999 Sep;116(3):603-13
pubmed: 10492260
Am J Respir Crit Care Med. 2013 Dec 1;188(11):1294-302
pubmed: 24200404
ERJ Open Res. 2018 May 18;4(2):
pubmed: 29796391
Gastroenterology. 2019 Feb;156(3):592-603.e10
pubmed: 30395812
Chest. 2008 Dec;134(6):1183-1191
pubmed: 18641116
J Allergy Clin Immunol Pract. 2019 May - Jun;7(5):1643-1646
pubmed: 30898690
J Asthma. 2015;52(9):969-73
pubmed: 26287942
Cochrane Database Syst Rev. 2006 Oct 18;(4):CD002884
pubmed: 17054154
J Allergy Clin Immunol. 2012 Feb;129(2):456-63, 463.e1-3
pubmed: 22206777
Expert Opin Med Diagn. 2011 Sep;5(5):453-65
pubmed: 23484630
J Allergy Clin Immunol. 2017 Nov;140(5):1423-1429.e5
pubmed: 28285844
N Engl J Med. 2012 Sep 27;367(13):1198-207
pubmed: 22938706
Thorax. 2013 Apr;68(4):322-9
pubmed: 23291349
J Asthma Allergy. 2013 May 06;6:53-60
pubmed: 23671393
Curr Opin Allergy Clin Immunol. 2019 Feb;19(1):61-67
pubmed: 30407207
Respirology. 2011 Aug;16(6):900-11
pubmed: 21692918
J Allergy Clin Immunol Pract. 2018 Sep - Oct;6(5):1496-1504
pubmed: 30197069
Am J Respir Crit Care Med. 2007 Dec 15;176(12):1185-91
pubmed: 17901415
Lancet Respir Med. 2020 Feb;8(2):158-170
pubmed: 31575508
Am J Respir Crit Care Med. 2017 May 1;195(9):1189-1197
pubmed: 28278391
J Allergy Clin Immunol. 2015 Jan;135(1):31-42
pubmed: 25468194
Curr Opin Pulm Med. 2019 Jan;25(1):1-10
pubmed: 30461532
Chest. 2018 May;153(5):1229-1239
pubmed: 28923762
Lancet. 2017 Nov 18;390(10109):2247-2255
pubmed: 28903864
Eur Respir J. 2018 Dec 13;52(6):
pubmed: 30190269
Expert Opin Drug Saf. 2019 May;18(5):369-380
pubmed: 30983432
J Allergy Clin Immunol. 2003 Aug;112(2):283-8
pubmed: 12897733
Lancet Respir Med. 2017 Dec;5(12):956-967
pubmed: 29146301
Cochrane Database Syst Rev. 2012 May 16;(5):CD006100
pubmed: 22592708
Respir Med. 2007 Dec;101(12):2437-46
pubmed: 17905575
Ann Allergy Asthma Immunol. 2011 Jun;106(6):451-6; quiz 457
pubmed: 21624743
Biomed Res Int. 2016;2016:9132198
pubmed: 27672663
J Allergy Clin Immunol. 2007 Jun;119(6):1337-48
pubmed: 17416409
J Allergy Clin Immunol. 2015 Feb;135(2):407-12
pubmed: 25441639
Cochrane Database Syst Rev. 2000;(4):CD002742
pubmed: 11034753
Int J Chron Obstruct Pulmon Dis. 2018 May 28;13:1747-1753
pubmed: 29881264
J Heart Lung Transplant. 2004 Mar;23(3):309-16
pubmed: 15019640
Nat Rev Immunol. 2018 Jul;18(7):454-466
pubmed: 29626211
JAMA. 2016 Jan 26;315(4):362-70
pubmed: 26813209
J Allergy Clin Immunol. 2006 Jan;117(1):18-24; quiz 25
pubmed: 16387578
J Allergy Clin Immunol. 2018 Jul;142(1):24-31.e2
pubmed: 29859203
Respir Med. 2010 May;104(5):644-51
pubmed: 20031382
J Allergy Clin Immunol. 2016 Jul;138(1):142-149.e8
pubmed: 26915674
Acad Radiol. 2018 Feb;25(2):169-178
pubmed: 29174189
Am J Respir Crit Care Med. 2009 Jan 1;179(1):19-24
pubmed: 18990678
Thorax. 2008 Nov;63(11):981-7
pubmed: 18678701
J Immunol. 2002 Mar 1;168(5):2464-9
pubmed: 11859139
Gastroenterology. 2007 Oct;133(4):1342-63
pubmed: 17919504
N Engl J Med. 2014 Jul 10;371(2):130-9
pubmed: 25006719
CJEM. 2007 Jul;9(4):304-8
pubmed: 17626698
PLoS One. 2019 Jan 24;14(1):e0210915
pubmed: 30677059
J Allergy Clin Immunol. 2009 Nov;124(5):1106-8
pubmed: 19800677
Pharmacol Rev. 2012 Jul;64(3):450-504
pubmed: 22611179
J Allergy Clin Immunol. 2019 Feb;143(2):577-590
pubmed: 29902480
J Allergy Clin Immunol. 2011 Jul;128(1):3-20.e6; quiz 21-2
pubmed: 21477849
World Allergy Organ J. 2019 Jan 26;12(1):100007
pubmed: 30937132
Chest. 2017 Feb;151(2):455-467
pubmed: 27693595
Lancet. 2017 Aug 12;390(10095):659-668
pubmed: 28687413
Int J Chron Obstruct Pulmon Dis. 2016 Nov 30;11:3007-3013
pubmed: 27942210
Gut. 2010 Jan;59(1):21-30
pubmed: 19828470
J Allergy Clin Immunol. 2015 Apr;135(4):896-902
pubmed: 25441637
Eur Respir J. 2014 Feb;43(2):343-73
pubmed: 24337046
J Asthma. 2017 Apr;54(3):294-299
pubmed: 27715354
Respirology. 2017 Oct;22(7):1262-1275
pubmed: 28776330
Am J Respir Crit Care Med. 2011 Sep 15;184(6):662-71
pubmed: 21680942
Lancet Respir Med. 2016 Oct;4(10):797-806
pubmed: 27574788
J Appl Physiol (1985). 2008 Feb;104(2):394-403
pubmed: 17991792
Clin Chest Med. 2014 Mar;35(1):143-56
pubmed: 24507842
PLoS One. 2015 Jun 19;10(6):e0128757
pubmed: 26090665
Curr Opin Allergy Clin Immunol. 2018 Apr;18(2):109-116
pubmed: 29389732
Multidiscip Respir Med. 2017 Nov 2;12:27
pubmed: 29118982
J Allergy Clin Immunol. 2011 Dec;128(6):1349-1350.e5
pubmed: 22019091
Respirology. 2016 Nov;21(8):1384-1390
pubmed: 27363539
Am J Respir Crit Care Med. 2013 Oct 15;188(8):e13-64
pubmed: 24127811
Eur Respir J. 2018 May 10;51(5):
pubmed: 29545284
N Engl J Med. 2017 May 18;376(20):1921-1932
pubmed: 28514601
Lancet Respir Med. 2017 Nov;5(11):881-890
pubmed: 28986128
Am J Respir Crit Care Med. 2000 Dec;162(6):2341-51
pubmed: 11112161
Chest. 2017 Dec;152(6):1203-1213
pubmed: 28941741
Ann Allergy Asthma Immunol. 2015 Jan;114(1):18-22
pubmed: 25455518
Ann Am Thorac Soc. 2016 Nov;13(11):2064-2077
pubmed: 27831798
Nat Immunol. 2019 May;20(5):637-651
pubmed: 30962590
J Allergy Clin Immunol Pract. 2019 May - Jun;7(5):1462-1468
pubmed: 30368004
BJOG. 2011 Oct;118(11):1314-23
pubmed: 21749633
N Engl J Med. 2017 Sep 7;377(10):936-946
pubmed: 28877011
Am J Respir Crit Care Med. 2012 May 15;185(10):1058-64
pubmed: 22403800
Clin Exp Allergy. 2012 Jul;42(7):1097-103
pubmed: 22702508
Respir Med. 2004 Sep;98(9):838-43
pubmed: 15338795
ERJ Open Res. 2016 Jul 29;2(3):
pubmed: 27730207
Respir Care. 2018 Jun;63(6):783-796
pubmed: 29794211
Nat Commun. 2017 Nov 16;8(1):1531
pubmed: 29142274
Arthritis Rheum. 1990 Aug;33(8):1135-6
pubmed: 2202312
J Allergy Clin Immunol Pract. 2019 Jan;7(1):71-80
pubmed: 30193939
Eur Respir J. 2017 Aug 31;50(2):
pubmed: 28860265
Am J Respir Crit Care Med. 2010 Jan 15;181(2):116-24
pubmed: 19815809
Am J Respir Crit Care Med. 2013 Apr 1;187(7):690-6
pubmed: 23348973
Gastroenterology. 2014 Sep;147(3):602-9
pubmed: 24907494
Eur Respir J. 2011 Jul;38(1):42-9
pubmed: 21177843
Lancet Respir Med. 2018 Jan;6(1):51-64
pubmed: 28919200
BMJ. 2017 Feb 15;356:i6583
pubmed: 28202713
Am J Respir Crit Care Med. 2001 Mar;163(4):994-1001
pubmed: 11282779
Asthma Res Pract. 2016 Jan 4;2:2
pubmed: 27965770
Cochrane Database Syst Rev. 2012 Dec 12;12:CD010179
pubmed: 23235685
J Heart Lung Transplant. 2005 Oct;24(10):1700-3
pubmed: 16210150
Chest. 2015 Oct;148(4):870-876
pubmed: 25789861
Eur Respir J. 2014 Apr;43(4):1067-76
pubmed: 24136334
Int Arch Allergy Immunol. 2009;149 Suppl 1:61-5
pubmed: 19494507
Eur Respir J. 1999 May;13(5):1198-208
pubmed: 10414427