PTEN Function at the Interface between Cancer and Tumor Microenvironment: Implications for Response to Immunotherapy.
PTEN
cancer
immune cells
immunoevasion
immunotherapy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Jul 2020
27 Jul 2020
Historique:
received:
13
06
2020
revised:
22
07
2020
accepted:
24
07
2020
entrez:
31
7
2020
pubmed:
31
7
2020
medline:
18
2
2021
Statut:
epublish
Résumé
Mounting preclinical and clinical evidence indicates that rewiring the host immune system in favor of an antitumor microenvironment achieves remarkable clinical efficacy in the treatment of many hematological and solid cancer patients. Nevertheless, despite the promising development of many new and interesting therapeutic strategies, many of these still fail from a clinical point of view, probably due to the lack of prognostic and predictive biomarkers. In that respect, several data shed new light on the role of the tumor suppressor phosphatase and tensin homolog on chromosome 10 (PTEN) in affecting the composition and function of the tumor microenvironment (TME) as well as resistance/sensitivity to immunotherapy. In this review, we summarize current knowledge on PTEN functions in different TME compartments (immune and stromal cells) and how they can modulate sensitivity/resistance to different immunological manipulations and ultimately influence clinical response to cancer immunotherapy.
Identifiants
pubmed: 32727102
pii: ijms21155337
doi: 10.3390/ijms21155337
pmc: PMC7432882
pii:
doi:
Substances chimiques
PTEN Phosphohydrolase
EC 3.1.3.67
PTEN protein, human
EC 3.1.3.67
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 18622
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 23857
Organisme : IFO Sperimentazioni OM1
ID : n.a.
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