SIRT1 Promotes Neuronal Fortification in Neurodegenerative Diseases through Attenuation of Pathological Hallmarks and Enhancement of Cellular Lifespan.
SIRT1
genomic stability
neuoroprotection
neurodegenerative disease.
neurogenesis
oxidative stress
Journal
Current neuropharmacology
ISSN: 1875-6190
Titre abrégé: Curr Neuropharmacol
Pays: United Arab Emirates
ID NLM: 101157239
Informations de publication
Date de publication:
2021
2021
Historique:
received:
03
05
2020
revised:
01
06
2020
accepted:
29
06
2020
pubmed:
31
7
2020
medline:
26
11
2021
entrez:
31
7
2020
Statut:
ppublish
Résumé
Neurodegeneration is a complex neurological phenomenon characterized by disturbed coherence in neuronal efflux. Progressive neuronal loss and brain damage due to various age-related pathological hallmarks perturb the behavioral balance and quality of life. Sirtuins have been widely investigated for their neuroprotective role, with SIRT1 being the most contemplated member of the family. SIRT1 exhibits significant capabilities to enhance neurogenesis and cellular lifespan by regulating various pathways, which makes it an exciting therapeutic target to inhibit neurodegenerative disease progression. SIRT1 mediated neuronal fortification involves modulation of molecular co-factors and biochemical pathways responsible for the induction and sustenance of pro-inflammatory and pro-oxidative environment in the cellular milieu. In this review, we present the major role played by SIRT1 in maintaining cellular strength through the regulation of genomic stability, neuronal growth, energy metabolism, oxidative stress, inhibiting mechanisms and anti-inflammatory responses. The therapeutic significance of SIRT1 has been put into perspective through a comprehensive discussion about its ameliorating potential against neurodegenerative stimuli in a variety of diseases that characteristically impair cognition, memory and motor coordination. This review enhances the acquaintance concerned with the neuroprotective potential of SIRT1 and thus promotes the development of novel SIRT1 regulating therapeutic agents and strategies.
Identifiants
pubmed: 32727328
pii: CN-EPUB-108625
doi: 10.2174/1570159X18666200729111744
pmc: PMC8686317
doi:
Substances chimiques
SIRT1 protein, human
EC 3.5.1.-
Sirtuin 1
EC 3.5.1.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1019-1037Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Références
Neuropharmacology. 2010 Jul-Aug;59(1-2):70-6
pubmed: 20381504
Mol Aspects Med. 2008 Jun;29(3):187-200
pubmed: 17397914
Neurodegener Dis. 2012;9(1):1-10
pubmed: 22041967
J Neurosci. 2012 Jan 4;32(1):124-32
pubmed: 22219275
Mol Cells. 2016 Feb;39(2):87-95
pubmed: 26831453
Mol Med. 2015 Mar 12;20:612-24
pubmed: 25517228
Curr Neuropharmacol. 2019;17(10):914-915
pubmed: 31580242
Biochim Biophys Acta. 2012 Sep-Oct;1819(9-10):914-20
pubmed: 22142616
J Cereb Blood Flow Metab. 2011 Apr;31(4):1003-19
pubmed: 21224864
Science. 2003 Oct 31;302(5646):834-8
pubmed: 14593170
PLoS One. 2008 Mar 05;3(3):e1710
pubmed: 18320031
Nature. 1991 Jul 4;352(6330):77-9
pubmed: 2062380
Front Neurosci. 2018 Oct 26;12:778
pubmed: 30416425
Biochem Biophys Res Commun. 2012 Jun 15;422(4):693-6
pubmed: 22613205
PLoS One. 2009 Dec 15;4(12):e8322
pubmed: 20020036
Autophagy. 2017 Feb;13(2):442-443
pubmed: 27929719
PLoS One. 2012;7(10):e47073
pubmed: 23056585
Front Pharmacol. 2019 Aug 27;10:920
pubmed: 31507418
Cell Mol Life Sci. 2012 Apr;69(7):1153-65
pubmed: 21984601
Nat Med. 2011 Dec 18;18(1):159-65
pubmed: 22179316
Front Neurosci. 2018 Nov 21;12:833
pubmed: 30519156
Nat Rev Dis Primers. 2017 Oct 05;3:17071
pubmed: 28980624
Endocrinology. 2014 Jul;155(7):2423-35
pubmed: 24773342
Curr Neuropharmacol. 2016;14(1):55-71
pubmed: 26487502
EMBO J. 2004 Jun 16;23(12):2369-80
pubmed: 15152190
Mol Neurobiol. 2013 Dec;48(3):490-9
pubmed: 23475611
Front Endocrinol (Lausanne). 2018 Dec 06;9:748
pubmed: 30574122
Prog Neurobiol. 2011 Nov;95(3):373-95
pubmed: 21930182
Brain Res Bull. 2016 Mar;121:9-15
pubmed: 26639783
Nutrients. 2017 Oct 14;9(10):
pubmed: 29036903
Neuroscience. 2009 Mar 31;159(3):993-1002
pubmed: 19356683
IUBMB Life. 2016 Sep;68(9):717-21
pubmed: 27364681
Neurosci Lett. 2008 Oct 31;444(3):217-21
pubmed: 18760331
Acta Neuropathol Commun. 2014 Jan 02;2:3
pubmed: 24383546
J Biol Chem. 2006 Aug 4;281(31):21745-21754
pubmed: 16751189
Diabetologia. 2014 Apr;57(4):819-31
pubmed: 24374551
Front Cell Neurosci. 2015 Mar 09;9:64
pubmed: 25805970
J Biol Chem. 1999 Dec 24;274(52):37111-6
pubmed: 10601271
J Cell Physiol. 2014 Sep;229(9):1224-35
pubmed: 24435709
J Neurochem. 2009 Sep;110(5):1445-56
pubmed: 19558452
Cell Res. 2013 Sep;23(9):1073-4
pubmed: 23856645
J Clin Invest. 2011 Nov;121(11):4281-8
pubmed: 21985785
Crit Rev Food Sci Nutr. 2017 Aug 13;57(12):2589-2599
pubmed: 26357880
J Biol Chem. 2007 Nov 23;282(47):34356-64
pubmed: 17901049
Biochem Biophys Res Commun. 2016 May 13;473(4):1301-1308
pubmed: 27086847
J Alzheimers Dis. 2006 Dec;10(4):417-22
pubmed: 17183154
Front Aging Neurosci. 2015 Mar 02;7:18
pubmed: 25784874
PLoS Biol. 2013 Jul;11(7):e1001603
pubmed: 23874150
Nat Commun. 2019 Nov 21;10(1):5284
pubmed: 31754102
J Neurosci Res. 2011 Nov;89(11):1723-36
pubmed: 21826702
Brain Res. 2013 Oct 16;1535:14-23
pubmed: 23994215
Curr Neuropharmacol. 2019;17(3):295-306
pubmed: 30479218
Curr Neuropharmacol. 2016;14(3):260-71
pubmed: 26517052
Cell. 2010 Jul 23;142(2):320-32
pubmed: 20655472
Antioxid Redox Signal. 2013 Jun 20;18(18):2444-57
pubmed: 23216311
Cell. 2001 Oct 19;107(2):149-59
pubmed: 11672523
Biochem Biophys Res Commun. 2017 Nov 4;493(1):821-826
pubmed: 28888980
Lancet. 2017 Nov 4;390(10107):2084-2098
pubmed: 28552366
Neuroscience. 2014 Jun 6;269:256-64
pubmed: 24709042
Biochim Biophys Acta. 2012 Sep-Oct;1819(9-10):921-9
pubmed: 22465614
J Neurosci Res. 1999 Jul 15;57(2):195-206
pubmed: 10398297
Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3374-9
pubmed: 18296641
Trends Biochem Sci. 2013 Mar;38(3):160-7
pubmed: 23394938
Neurochem Int. 2012 Dec;61(8):1357-63
pubmed: 23036362
Muscle Nerve. 2011 Jul;44(1):20-4
pubmed: 21607987
Curr Neuropharmacol. 2018;16(7):1086-1097
pubmed: 29189163
Autophagy. 2012 Oct;8(10):1494-509
pubmed: 22914317
J Neurosci. 2008 Aug 27;28(35):8772-84
pubmed: 18753379
Front Pharmacol. 2019 Sep 12;10:1008
pubmed: 31572186
Circ Res. 2010 Apr 30;106(8):1384-93
pubmed: 20203304
Mol Med Rep. 2015 Jan;11(1):521-6
pubmed: 25333348
Nature. 2010 Aug 26;466(7310):1105-9
pubmed: 20622856
Cell Rep. 2016 Oct 11;17(3):809-820
pubmed: 27732856
Stroke. 2008 Sep;39(9):2587-95
pubmed: 18617666
Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3602-9
pubmed: 17652729
Front Pharmacol. 2018 Oct 16;9:1162
pubmed: 30405405
Cell Metab. 2013 Aug 6;18(2):251-64
pubmed: 23931756
Cold Spring Harb Perspect Med. 2017 Aug 1;7(8):
pubmed: 28003278
Cold Spring Harb Perspect Med. 2015 Sep 18;5(10):
pubmed: 26385091
Cell Metab. 2008 Jul;8(1):38-48
pubmed: 18590691
J Neurosci. 2008 Oct 1;28(40):9989-96
pubmed: 18829956
Nat Rev Mol Cell Biol. 2008 Mar;9(3):206-18
pubmed: 18292778
Indian J Med Res. 2019 May;149(5):610-615
pubmed: 31417028
Development. 2014 Dec;141(24):4697-709
pubmed: 25468938
P T. 2015 Aug;40(8):504-32
pubmed: 26236139
Eur J Neurosci. 2006 Apr;23(7):1711-20
pubmed: 16623827
Aging Cell. 2018 Dec;17(6):e12839
pubmed: 30295421
Neurochem Res. 2018 Sep;43(9):1791-1801
pubmed: 30022380
J Neurosci. 2010 Jul 21;30(29):9695-707
pubmed: 20660252
Anesthesiology. 2012 Feb;116(2):352-61
pubmed: 22198221
Hum Mol Genet. 2008 Dec 1;17(23):3767-75
pubmed: 18762557
Curr Neuropharmacol. 2020;18(9):883-903
pubmed: 32348223
Cell Rep. 2014 Mar 13;6(5):836-43
pubmed: 24582957
Front Neurol. 2012 May 24;3:84
pubmed: 22654783
Mech Ageing Dev. 2005 Oct;126(10):1097-105
pubmed: 15964060
Nat Neurosci. 2001 Dec;4(12):1199-206
pubmed: 11770485
Nat Med. 2011 Dec 18;18(1):153-8
pubmed: 22179319
Mol Cell Biochem. 2017 Nov;435(1-2):149-162
pubmed: 28551846
Front Cell Neurosci. 2018 Aug 21;12:267
pubmed: 30186119
Stroke. 2013 Aug;44(8):2333-7
pubmed: 23723308
J Mol Biol. 2014 Feb 6;426(3):526-41
pubmed: 24120939
Nat Rev Mol Cell Biol. 2012 Mar 07;13(4):225-238
pubmed: 22395773
Neurochem Res. 2012 Dec;37(12):2686-96
pubmed: 22878646
Biochim Biophys Acta. 2010 Aug;1804(8):1666-75
pubmed: 19879981
Int J Mol Sci. 2015 Mar 11;16(3):5572-89
pubmed: 25768341
Indian J Med Res. 2014 May;139(5):667-74
pubmed: 25027075
Nature. 2006 Oct 19;443(7113):787-95
pubmed: 17051205
J Exp Med. 2005 Nov 7;202(9):1163-9
pubmed: 16260491
Stem Cells. 2014 Dec;32(12):3219-31
pubmed: 25132403
Neuroscience. 2014 Dec 5;281:251-7
pubmed: 25281876
J Neurosci. 2011 Nov 30;31(48):17425-36
pubmed: 22131404
Bioorg Med Chem. 2011 Jun 15;19(12):3616-24
pubmed: 21306906
Mol Biol Cell. 2011 Feb 15;22(4):503-12
pubmed: 21169561
Trends Pharmacol Sci. 2012 Sep;33(9):494-501
pubmed: 22749331
Recent Pat CNS Drug Discov. 2008 Jan;3(1):61-9
pubmed: 18221243
Front Biosci. 2007 Jan 01;12:1079-93
pubmed: 17127363
Nat Rev Genet. 2009 Jan;10(1):32-42
pubmed: 19065135
Exp Gerontol. 2012 Feb;47(2):198-201
pubmed: 22143179
Cell Cycle. 2006 Apr;5(8):873-7
pubmed: 16628003
Cell Commun Signal. 2011 May 08;9:11
pubmed: 21549004
EMBO J. 2007 Apr 4;26(7):1913-23
pubmed: 17347648
Curr Eye Res. 2016 Jun;41(6):844-55
pubmed: 26200953
J Endocrinol. 2010 Feb;204(2):93-104
pubmed: 19770177
J Tissue Eng Regen Med. 2019 Jan;13(1):110-115
pubmed: 30479062
Mol Brain. 2014 Aug 29;7:62
pubmed: 25167838
EMBO J. 2007 Jul 11;26(13):3169-79
pubmed: 17581637
Neurobiol Learn Mem. 2012 Jul;98(1):25-32
pubmed: 22542746
Crit Rev Eukaryot Gene Expr. 2017;27(4):321-329
pubmed: 29283326
Adv Neurobiol. 2016;12:401-14
pubmed: 27651266
Biochem Pharmacol. 2007 Feb 15;73(4):550-60
pubmed: 17147953
Ageing Res Rev. 2012 Apr;11(2):230-41
pubmed: 22186033
Cell. 2006 Oct 6;127(1):59-69
pubmed: 17018277
Oxid Med Cell Longev. 2020 Feb 18;2020:9018624
pubmed: 32148659
J Biol Chem. 2010 Mar 19;285(12):9100-13
pubmed: 20080969
Mol Neurodegener. 2008 Dec 29;3:21
pubmed: 19114014
Curr Neuropharmacol. 2019;17(5):406-421
pubmed: 29338678
Int J Mol Sci. 2019 Jul 23;20(14):
pubmed: 31340436
Nature. 2005 Mar 3;434(7029):113-8
pubmed: 15744310
J Neuroophthalmol. 2010 Dec;30(4):328-39
pubmed: 21107122
Neuron. 2014 Feb 5;81(3):471-83
pubmed: 24507186
Mol Cell Biol. 2006 Nov;26(21):8122-35
pubmed: 16923962
Nat Genet. 2005 Apr;37(4):339-40
pubmed: 15800644
Science. 1983 Feb 25;219(4587):979-80
pubmed: 6823561
Mol Cell Biol. 2011 Dec;31(23):4720-34
pubmed: 21947282
J Neurosci Res. 2013 May;91(5):642-59
pubmed: 23404532
J Neurochem. 2006 Jan;96(2):305-13
pubmed: 16219030
Front Pharmacol. 2018 Jan 05;8:954
pubmed: 29354057
J Neurosci. 2012 Sep 5;32(36):12630-40
pubmed: 22956852
Ann Neurol. 2008 Nov;64(5):507-13
pubmed: 19067365
Exp Mol Pathol. 2014 Apr;96(2):139-48
pubmed: 24397908
J Neurosci. 2011 Jun 29;31(26):9746-51
pubmed: 21715639
Oxid Med Cell Longev. 2019 May 9;2019:2105607
pubmed: 31210837
Front Mol Neurosci. 2019 May 28;12:132
pubmed: 31191244
Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14855-60
pubmed: 17785417
J Neurosci. 2010 Sep 1;30(35):11815-25
pubmed: 20810901
Expert Opin Ther Targets. 2015 Apr;19(4):471-87
pubmed: 25652642
J Biol Chem. 2005 Dec 30;280(52):43121-30
pubmed: 16207712
Curr Neuropharmacol. 2018 Jan 30;16(2):126-136
pubmed: 28676015
Neurology. 2008 Sep 16;71(12):876-81
pubmed: 18596241
J Neurosci. 2010 Feb 24;30(8):2967-78
pubmed: 20181594
Mov Disord. 2011 Oct;26(12):2160-8
pubmed: 21887711
EMBO Mol Med. 2013 Mar;5(3):344-52
pubmed: 23417962
Nat Rev Neurol. 2016 Sep;12(9):526-38
pubmed: 27514291
J Biol Chem. 2009 Aug 7;284(32):21379-85
pubmed: 19542216
Biochim Biophys Acta. 2016 Jun;1862(6):1093-104
pubmed: 26964795
PLoS Biol. 2006 Feb;4(2):e31
pubmed: 16366736
Nat Cell Biol. 2008 Apr;10(4):385-94
pubmed: 18344989
Cell Death Dis. 2018 Jan 25;9(2):119
pubmed: 29371661
J Biol Chem. 2005 Dec 2;280(48):40364-74
pubmed: 16183991