Renal function deterioration in adult patients with type-2 diabetes.
Aged
Aged, 80 and over
Albuminuria
/ epidemiology
Antihypertensive Agents
/ therapeutic use
Diabetes Mellitus, Type 2
/ complications
Diabetic Nephropathies
/ etiology
Disease Progression
Dyslipidemias
/ epidemiology
Female
Glomerular Filtration Rate
Humans
Hypertension
/ drug therapy
Hypoglycemic Agents
/ therapeutic use
Male
Middle Aged
Prevalence
Registries
Renal Insufficiency, Chronic
/ epidemiology
Chronic kidney disease
Dyslipidemia
Hypertension
Type 2 diabetes
eGFR slope
Journal
BMC nephrology
ISSN: 1471-2369
Titre abrégé: BMC Nephrol
Pays: England
ID NLM: 100967793
Informations de publication
Date de publication:
29 07 2020
29 07 2020
Historique:
received:
07
02
2020
accepted:
15
07
2020
entrez:
31
7
2020
pubmed:
31
7
2020
medline:
16
10
2021
Statut:
epublish
Résumé
To explore, in a large group of patients with type-2 diabetes (T2DM), renal function decline in terms of the slope of the estimated glomerular filtration rate (eGFR) over time, and to find out how classical risk factors, such as the presence of hypertension, dyslipidemia and microalbuminuria, affect the renal function. The analysis included 32,492 adult T2DM patients from the DIVE/DPV registries who had serial eGFR determinations and information on the presence of microalbuminuria, hypertension and dyslipidemia available. Patients had a mean age of 66.3 years, 52.6% were male with a mean BMI of 31.7 kg/m CKD is highly prevalent in patients with T2DM. Serial surveillance of the glomerular filtration rate is, however, not established in clinical practice, which would be necessary as indicated by a doubling of patients with an eGFR < 30 mL/min/1.73 m
Sections du résumé
BACKGROUND
To explore, in a large group of patients with type-2 diabetes (T2DM), renal function decline in terms of the slope of the estimated glomerular filtration rate (eGFR) over time, and to find out how classical risk factors, such as the presence of hypertension, dyslipidemia and microalbuminuria, affect the renal function.
METHODS
The analysis included 32,492 adult T2DM patients from the DIVE/DPV registries who had serial eGFR determinations and information on the presence of microalbuminuria, hypertension and dyslipidemia available.
RESULTS
Patients had a mean age of 66.3 years, 52.6% were male with a mean BMI of 31.7 kg/m
CONCLUSION
CKD is highly prevalent in patients with T2DM. Serial surveillance of the glomerular filtration rate is, however, not established in clinical practice, which would be necessary as indicated by a doubling of patients with an eGFR < 30 mL/min/1.73 m
Identifiants
pubmed: 32727401
doi: 10.1186/s12882-020-01952-0
pii: 10.1186/s12882-020-01952-0
pmc: PMC7391505
doi:
Substances chimiques
Antihypertensive Agents
0
Hypoglycemic Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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