Periodontal disease and incident dementia: The Atherosclerosis Risk in Communities Study (ARIC).

Aged Cohort Studies Dementia / epidemiology Female Humans Incidence Male Middle Aged Periodontal Diseases / complications Risk Factors

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
22 09 2020
Historique:
received: 23 08 2019
accepted: 06 04 2020
pubmed: 31 7 2020
medline: 31 10 2020
entrez: 31 7 2020
Statut: ppublish

Résumé

To test the hypothesis that periodontal disease would be associated with increased risk for dementia and mild cognitive impairment (MCI) by assessing dementia/MCI outcomes after a baseline periodontal examination. Participants enrolled in the Atherosclerosis Risk in Communities study with a clinical periodontal examination (or edentulous participants) at visit 4 (1996-1998; mean ± SD age 63 ± 6 years, 55% female, 21% black) and adjudicated dementia outcomes through 2016 were included (n = 8,275). A subgroup of 4,559 participants had adjudicated dementia and MCI assessments at visit 5 (2011-2013). Participants received a full-mouth periodontal examination and were classified into periodontal profile classes (PPCs) based on the severity and extent of gingival inflammation and attachment loss. MCI and dementia were determined via neurocognitive testing, neurological examination and history, informant interviews, and brain MRI in a subset. Cox proportional hazards models regressed incident dementia on PPCs. Relative risk regression models were used for the composite of MCI/dementia. The cumulative incidence and incidence density of dementia during follow-up (average 18.4 years) were 19% (n = 1,569) and 11.8 cases per 1,000 person-years. Multivariable adjusted hazard ratios for incident dementia among participants with severe PPC or edentulism (vs periodontal healthy) were 1.22 (95% confidence interval [CI] 1.01-1.47) and 1.21 (95% CI 0.99-1.48), respectively. For the combined dementia/MCI outcome, adjusted risk ratios among participants with mild/intermediate PPC, severe PPC, or edentulism (vs periodontal healthy) were 1.22 (95% CI 1.00-1.48), 1.15 (95% CI 0.88-1.51), and 1.90 (95% CI 1.40-2.58). Results were stronger among younger (≤62 years) participants ( Periodontal disease was modestly associated with incident MCI and dementia in a community-based cohort of black and white participants.

Identifiants

DOI: 10.1212/WNL.0000000000010312 PMID: 32727837 PMC: PMC7713724
pubmed: 32727837
pii: WNL.0000000000010312
doi: 10.1212/WNL.0000000000010312
pmc: PMC7713724
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1660-e1671

Subventions

Organisme : NHLBI NIH HHS
ID : U01 HL096812
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004I
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096902
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005I
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096899
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003I
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096814
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096917
Pays : United States

Informations de copyright

© 2020 American Academy of Neurology.

Références

Curr Neurol Neurosci Rep. 2013 Oct;13(10):384
pubmed: 23963608
Alzheimers Dement. 2011 May;7(3):270-9
pubmed: 21514249
JDR Clin Trans Res. 2017 Oct;2(4):330-342
pubmed: 30931751
J Periodontol. 2017 Feb;88(2):153-165
pubmed: 27620653
Arch Intern Med. 2000 Oct 9;160(18):2749-55
pubmed: 11025784
J Dent Res. 2011 Jan;90(1):41-6
pubmed: 21041549
J Clin Periodontol. 2006 Jun;33(6):401-7
pubmed: 16677328
J Am Geriatr Soc. 2017 Sep;65(9):1975-1980
pubmed: 28598507
J Neuroinflammation. 2011 Aug 04;8:90
pubmed: 21816039
Am J Clin Nutr. 1982 Nov;36(5):936-42
pubmed: 7137077
Stroke. 2004 Sep;35(9):2029-35
pubmed: 15256677
Community Dent Oral Epidemiol. 2015 Feb;43(1):47-57
pubmed: 25363061
J Periodontol. 2007 Jul;78(7 Suppl):1387-99
pubmed: 17608611
Am J Epidemiol. 1989 Apr;129(4):687-702
pubmed: 2646917
BMC Psychiatry. 2018 Oct 20;18(1):345
pubmed: 30342524
Eur Heart J. 1987 Sep;8(9):1007-14
pubmed: 3665952
J Periodontol. 2018 Feb;89(2):166-175
pubmed: 29520827
J Clin Periodontol. 2014 Jul;41(7):643-52
pubmed: 24708451
Stroke. 1999 Apr;30(4):736-43
pubmed: 10187871
J Clin Periodontol. 2017 Mar;44(3):266-274
pubmed: 28036104
J Dent Res. 2015 Sep;94(9 Suppl):201S-11S
pubmed: 26082387
Lancet Neurol. 2011 Sep;10(9):819-28
pubmed: 21775213
J Clin Periodontol. 2017 Mar;44(3):255-265
pubmed: 27978598
J Clin Periodontol. 2009 Apr;36(4):287-94
pubmed: 19426174
Diabetes Care. 2008 Jul;31(7):1373-9
pubmed: 18390797
Neurology. 1993 Feb;43(2):250-60
pubmed: 8094895
Clin Chem. 1972 Jun;18(6):499-502
pubmed: 4337382
Stroke. 2018 Feb;49(2):355-362
pubmed: 29335336
Sci Adv. 2019 Jan 23;5(1):eaau3333
pubmed: 30746447
JAMA Neurol. 2017 Oct 1;74(10):1246-1254
pubmed: 28783817
Am J Cardiol. 2008 Apr 1;101(7):1016-22
pubmed: 18359324
Periodontol 2000. 2005;38:135-87
pubmed: 15853940
Stroke. 2003 Sep;34(9):2120-5
pubmed: 12893951
J Dent Res. 2013 Sep;92(9):795-801
pubmed: 23872988
Alzheimers Dement (Amst). 2016;2:1-11
pubmed: 26949733
J Periodontol. 2018 Feb;89(2):157-165
pubmed: 29520823
Circulation. 2008 Apr 1;117(13):1668-74
pubmed: 18362228
Diabetes Care. 2006 Dec;29(12):2688-93
pubmed: 17130206
Ann Neurol. 2002 Aug;52(2):168-74
pubmed: 12210786
J Dent Res. 2010 Sep;89(9):879-902
pubmed: 20639510
Curr Neuropharmacol. 2017;15(7):996-1009
pubmed: 28294067
J Am Dent Assoc. 2013 Dec;144(12):1362-71
pubmed: 24282266
J Clin Epidemiol. 1996 Feb;49(2):223-33
pubmed: 8606324
Stroke. 2003 Jan;34(1):47-52
pubmed: 12511749
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Heart. 2007 Sep;93(9):1098-103
pubmed: 17164486
Br Dent J. 2018 Jan;223(11):846-853
pubmed: 29192686
PLoS One. 2013 Oct 14;8(10):e77441
pubmed: 24155956

Auteurs

Ryan T Demmer (RT)

From the Division of Epidemiology and Community Health (R.T.D., F.L.N., K.L., J.S.P., A.R.F., P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (R.T.D.), Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (K.A.W.), Johns Hopkins School of Medicine, Baltimore, MD; Department of Medicine (T.M.), University of Mississippi Medical Center, Jackson; and Division of Comprehensive Oral Health-Periodontology (J.B.), Adams School of Dentistry, University of North Carolina at Chapel Hill. demm0009@umn.edu.
ORCID: 0000-0003-3429-0379

Faye L Norby (FL)

From the Division of Epidemiology and Community Health (R.T.D., F.L.N., K.L., J.S.P., A.R.F., P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (R.T.D.), Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (K.A.W.), Johns Hopkins School of Medicine, Baltimore, MD; Department of Medicine (T.M.), University of Mississippi Medical Center, Jackson; and Division of Comprehensive Oral Health-Periodontology (J.B.), Adams School of Dentistry, University of North Carolina at Chapel Hill.
ORCID: 0000-0002-1975-0405

Kamakshi Lakshminarayan (K)

From the Division of Epidemiology and Community Health (R.T.D., F.L.N., K.L., J.S.P., A.R.F., P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (R.T.D.), Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (K.A.W.), Johns Hopkins School of Medicine, Baltimore, MD; Department of Medicine (T.M.), University of Mississippi Medical Center, Jackson; and Division of Comprehensive Oral Health-Periodontology (J.B.), Adams School of Dentistry, University of North Carolina at Chapel Hill.

Keenan A Walker (KA)

From the Division of Epidemiology and Community Health (R.T.D., F.L.N., K.L., J.S.P., A.R.F., P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (R.T.D.), Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (K.A.W.), Johns Hopkins School of Medicine, Baltimore, MD; Department of Medicine (T.M.), University of Mississippi Medical Center, Jackson; and Division of Comprehensive Oral Health-Periodontology (J.B.), Adams School of Dentistry, University of North Carolina at Chapel Hill.

James S Pankow (JS)

From the Division of Epidemiology and Community Health (R.T.D., F.L.N., K.L., J.S.P., A.R.F., P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (R.T.D.), Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (K.A.W.), Johns Hopkins School of Medicine, Baltimore, MD; Department of Medicine (T.M.), University of Mississippi Medical Center, Jackson; and Division of Comprehensive Oral Health-Periodontology (J.B.), Adams School of Dentistry, University of North Carolina at Chapel Hill.

Aaron R Folsom (AR)

From the Division of Epidemiology and Community Health (R.T.D., F.L.N., K.L., J.S.P., A.R.F., P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (R.T.D.), Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (K.A.W.), Johns Hopkins School of Medicine, Baltimore, MD; Department of Medicine (T.M.), University of Mississippi Medical Center, Jackson; and Division of Comprehensive Oral Health-Periodontology (J.B.), Adams School of Dentistry, University of North Carolina at Chapel Hill.

Thomas Mosley (T)

From the Division of Epidemiology and Community Health (R.T.D., F.L.N., K.L., J.S.P., A.R.F., P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (R.T.D.), Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (K.A.W.), Johns Hopkins School of Medicine, Baltimore, MD; Department of Medicine (T.M.), University of Mississippi Medical Center, Jackson; and Division of Comprehensive Oral Health-Periodontology (J.B.), Adams School of Dentistry, University of North Carolina at Chapel Hill.

Jim Beck (J)

From the Division of Epidemiology and Community Health (R.T.D., F.L.N., K.L., J.S.P., A.R.F., P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (R.T.D.), Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (K.A.W.), Johns Hopkins School of Medicine, Baltimore, MD; Department of Medicine (T.M.), University of Mississippi Medical Center, Jackson; and Division of Comprehensive Oral Health-Periodontology (J.B.), Adams School of Dentistry, University of North Carolina at Chapel Hill.

Pamela L Lutsey (PL)

From the Division of Epidemiology and Community Health (R.T.D., F.L.N., K.L., J.S.P., A.R.F., P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (R.T.D.), Mailman School of Public Health, Columbia University, New York, NY; Department of Neurology (K.A.W.), Johns Hopkins School of Medicine, Baltimore, MD; Department of Medicine (T.M.), University of Mississippi Medical Center, Jackson; and Division of Comprehensive Oral Health-Periodontology (J.B.), Adams School of Dentistry, University of North Carolina at Chapel Hill.
ORCID: 0000-0002-1572-1340

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Periodontal disease and incident dementia: The...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Periodontal disease and incident dementia: The...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Periodontal disease and incident dementia: The...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Periodontal disease and incident dementia: The...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Incidence › Periodontal disease and incident dementia: The...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Periodontal disease and incident dementia: The...
questionsmedicales.fr › Maladies du système stomatognathique › Maladies de la bouche › Maladies parodontales › Periodontal disease and incident dementia: The...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Periodontal disease and incident dementia: The...