Hepatocyte expression of the micropeptide adropin regulates the liver fasting response and is enhanced by caloric restriction.
Animals
Caloric Restriction
Cyclic AMP-Dependent Protein Kinases
/ genetics
Fasting
Gene Expression Regulation
Gluconeogenesis
/ genetics
Hepatocytes
/ cytology
Intercellular Signaling Peptides and Proteins
/ biosynthesis
Intracellular Signaling Peptides and Proteins
/ biosynthesis
Liver
/ cytology
Mice
Mice, Knockout
Phosphoenolpyruvate Carboxykinase (GTP)
/ biosynthesis
Signal Transduction
/ genetics
circadian rhythm
diet
glucagon
glucose metabolism
hepatocyte
insulin
peptide hormone
signal transduction
stress response
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
02 10 2020
02 10 2020
Historique:
received:
14
05
2020
revised:
22
07
2020
pubmed:
31
7
2020
medline:
4
2
2021
entrez:
31
7
2020
Statut:
ppublish
Résumé
The micropeptide adropin encoded by the clock-controlled energy homeostasis-associated gene is implicated in the regulation of glucose metabolism. However, its links to rhythms of nutrient intake, energy balance, and metabolic control remain poorly defined. Using surveys of Gene Expression Omnibus data sets, we confirm that fasting suppresses liver adropin expression in lean C57BL/6J (B6) mice. However, circadian rhythm data are inconsistent. In lean mice, caloric restriction (CR) induces bouts of compulsive binge feeding separated by prolonged fasting intervals, increasing NAD-dependent deacetylase sirtuin-1 signaling important for glucose and lipid metabolism regulation. CR up-regulates adropin expression and induces rhythms correlating with cellular stress-response pathways. Furthermore, adropin expression correlates positively with phosphoenolpyruvate carboxokinase-1 (
Identifiants
pubmed: 32727846
pii: S0021-9258(17)49826-7
doi: 10.1074/jbc.RA120.014381
pmc: PMC7535914
pii:
doi:
Substances chimiques
Enho protein, mouse
0
Intercellular Signaling Peptides and Proteins
0
Intracellular Signaling Peptides and Proteins
0
Cyclic AMP-Dependent Protein Kinases
EC 2.7.11.11
Pck1 protein, mouse
EC 4.1.1.32
Phosphoenolpyruvate Carboxykinase (GTP)
EC 4.1.1.32
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13753-13768Subventions
Organisme : NHLBI NIH HHS
ID : R00 HL136658
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS108138
Pays : United States
Informations de copyright
© 2020 Banerjee et al.
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
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